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Analysis of whole blood samples with low gas flow inductively coupled plasma-optical emission spectrometry

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Abstract

Low gas flow ICP-OES with a total argon consumption below 0.7 L/min is introduced for the analysis of trace elements in blood samples to investigate the influence of samples containing an organic solvent in a demanding matrix on the performance of this plasma for the first time. Therefore, gadolinium was determined in human plasma samples and mercury in red blood cells, human plasma, and precipitated plasma protein fraction. Limits of detection (LOD) were determined to be in the low microgram per liter range for the analytes and the accuracy of the method was assessed by comparison with a conventional Fassel-type torch-based ICP-OES. It was proven that the low gas flow ICP-OES leads to comparable results with the instrument based on the Fassel-type torch.

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Acknowledgments

The authors would like to thank Roland Konermann, Ines Meintrup, and Sabrina Leuschner (Center for Radiology and Nuclear Medicine, Münster, Germany) for the assistance in sample collection and Dagmar Strohbecke (Environmental Specimen Bank for Human Tissues, Münster, Germany) for the assistance in sample preparation. Dr. Dirk Ardelt and the Support Team from Spectro Analytical Instruments (Kleve, Germany) are gratefully acknowledged for their technical support.

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Authors and Affiliations

  1. Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstrasse 30, 48149, Münster, Germany

    Sascha Nowak, Jens Künnemeyer, Lydia Terborg, Stefan Trümpler, Uwe Karst & Wolfgang Buscher

  2. Environmental Specimen Bank for Human Tissues, Domagkstrasse 11, 48149, Münster, Germany

    Andreas Günsel & Gerhard A. Wiesmüller

Authors
  1. Sascha Nowak
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  2. Jens Künnemeyer
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  3. Lydia Terborg
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  4. Stefan Trümpler
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  5. Andreas Günsel
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  6. Gerhard A. Wiesmüller
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  7. Uwe Karst
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  8. Wolfgang Buscher
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Corresponding author

Correspondence to Sascha Nowak.

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Published in the topical collection celebrating ABCs 13th Anniversary.

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Nowak, S., Künnemeyer, J., Terborg, L. et al. Analysis of whole blood samples with low gas flow inductively coupled plasma-optical emission spectrometry. Anal Bioanal Chem 407, 1023–1026 (2015). https://doi.org/10.1007/s00216-014-8161-5

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  • DOI: https://doi.org/10.1007/s00216-014-8161-5

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