Abstract
Cancer is a complex disease characterized by dysregulated cell growth and division, posing significant challenges for effective treatment. Hispidulin, a flavonoid compound, has shown promising biological effects, particularly in the field of anticancer research. The main objective of this study is to investigate the anticancer properties of hispidulin and gain insight into its mechanistic targets in cancer cells. A comprehensive literature review was conducted to collect data on the anticancer effects of hispidulin. In vitro and in vivo studies were analyzed to identify the molecular targets and underlying mechanisms through which hispidulin exerts its anticancer activities. Hispidulin has shown significant effects on various aspects of cancer, including cell growth, proliferation, cell cycle regulation, angiogenesis, metastasis, and apoptosis. It has been observed to target both extrinsic and intrinsic apoptotic pathways, regulate cell cycle arrest, and modulate cancer progression pathways. The existing literature highlights the potential of hispidulin as a potent anticancer agent. Hispidulin exhibits promising potential as a therapeutic agent for cancer treatment. Its ability to induce apoptosis and modulate key molecular targets involved in cancer progression makes it a valuable candidate for further investigation. Additional pharmacological studies are needed to fully understand the specific targets and signaling pathways influenced by hispidulin in different types of cancer. Further research will contribute to the successful translation of hispidulin into clinical settings, allowing its utilization in conventional and advanced cancer therapies with improved therapeutic outcomes and reduced side effects.
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Abbreviations
- AKT:
-
serine/threonine kinase
- AMPK:
-
AMP-activated protein kinase
- BAK:
-
BCL2 antagonist killer 1
- BAX:
-
BCL2-associated X protein
- Bcl-2:
-
B-cell lymphoma protein 2
- Bcl-XL:
-
BCL2-related protein, long isoform
- CARD:
-
caspase recruitment domain
- Caspase-10:
-
cysteinyl aspartic acid-protease-10
- Caspase-3:
-
cysteinyl aspartic acid-protease-3
- Caspase-6:
-
cysteinyl aspartic acid-protease-6
- Caspase-7:
-
cysteinyl aspartic acid-protease-7
- caspase-8:
-
cysteinyl aspartic acid-protease 8
- COX-2 :
-
cyclooxygenase-2
- DED:
-
death effector domain
- ERK:
-
extracellular signal-regulated kinase
- FasL:
-
Fas ligand
- FasR:
-
Fas ligand-receptor
- GBM:
-
glioblastoma multiforme
- GLOBOCAN :
-
global cancer incidence, mortality, and prevalence
- GSH/GSSG:
-
reduced glutathione/oxidized glutathione
- HIF-1:
-
hypoxia-inducible factor-1
- HIS:
-
hispidulin
- HT-29 :
-
human colorectal adenocarcinoma cell line
- JAK:
-
Janus kinase
- MMP-2:
-
matrix metalloproteinase-2
- mTOR:
-
mammalian target of rapamycin
- OVX:
-
ovariectomy
- PARP:
-
poly (ADP-ribose) polymerase
- PI3K/:
-
phosphoinositide 3-kinase
- PTEN:
-
phosphatase and tensin homolog
- RCC:
-
renal cell carcinoma
- ROS:
-
reactive oxygen species
- STAT3:
-
signal transducer and activator of transcription 3
- TMZ:
-
temozolomide
- TNFR1:
-
type 1 TNF receptor
- TRAIL:
-
TNF-related apoptosis-inducing ligand
- TUNEL:
-
terminal deoxynucleotidyl transferase dUTP nick end labeling
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Chaudhry, GeS., Zeenia, Sharifi-Rad, J. et al. Hispidulin: a promising anticancer agent and mechanistic breakthrough for targeted cancer therapy. Naunyn-Schmiedeberg's Arch Pharmacol 397, 1919–1934 (2024). https://doi.org/10.1007/s00210-023-02645-9
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DOI: https://doi.org/10.1007/s00210-023-02645-9