Abstract
The aim of this study is to investigate the effects of all-trans retinoic acid (ATRA) use on cisplatin (CP)-induced nephrotoxicty. Twenty-eight rats were randomly divided into four groups. The rats in the control group were injected a single dose of 1 ml/kg saline intra-peritoneally (IP) during 10 days. The rats in the ATRA group were injected a single dose of ATRA during 10 days. The rats in the ATRA+CP group were injected a single dose of CP on the fourth day of the 10 days of ATRA treatment. The rats in the CP group were injected a single dose of CP on the fourth day of 10 days without administering a treatment. After treatment, the groups were compared with regard to total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels in renal tissue and renal histopathology. The serum creatinine and urea values were statistically significantly higher in the CP group compared to the other groups. The serum creatinine and urea values were statistically significantly lower in the ATRA+CP group when compared to the CP group. Although the TOS and OSI levels were found to be lower in the ATRA+CP group compared to the CP group, the difference was not statistically significant. Administration of ATRA together with CP was observed to reduce the histopathologic destruction in the kidney and lead to mild tubular degeneration, vacuolization, and necrosis (57.1% grade 1; 28.6% grade2, and 14.3% grade 3 necrosis). The results of the present study have revealed that ATRA administration ameliorates CP-induced nephrotoxicity; however, further studies are required to identify this issue before clinical application.
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Acknowledgements
We would like to thank to Pelin Teke Kisa, Serdar Bayrak, and Ozgur Cakmak for their contribution to the statistical analysis.
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CY and EEY conceived and designed research. CY, FDA, and SE conducted experiments. EK, VU, and MU contributed new reagents or analytical tools. CY and OC analyzed data. YOI, BB, and ZK made supervision. CY wrote the manuscript. All authors read and approved the manuscript.
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All procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals of the Research Council after approval had been obtained from the Dokuz Eylül University local ethical committee of animal experiments.
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Yucel, C., Erdogan Yucel, E., Arslan, F.D. et al. All-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats. Naunyn-Schmiedeberg's Arch Pharmacol 392, 159–164 (2019). https://doi.org/10.1007/s00210-018-01603-0
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DOI: https://doi.org/10.1007/s00210-018-01603-0