Abstract
Much of the beneficial effects of olive products have been attributed to oleuropein. This study examined the effects of oleuropein in rats with heart failure induced by permanent ligation of left coronary arteries. Twenty-four hours after the operation, the rats were assigned to five groups including a sham assigned to receive vehicle (1 ml/day) and four coronary ligated groups assigned to receive vehicle or oleuropein at 5, 10, or 20 mg/kg/day. Five weeks later, echocardiographic and hemodynamic parameters, serum concentrations of oxidative stress, and inflammatory markers were determined. Myocardial infarction group receiving vehicle showed impaired hemodynamic and echocardiographic parameters as evidenced by decreased left ventricular systolic pressure, rate of rise and decrease of left ventricular pressure, stroke volume, ejection fraction, and cardiac output. In addition, significant reduction in superoxide dismutase and glutathione reductase was observed. Oleuropein treatment prevented the reduction of these variables. Moreover, the group had a significantly higher infarct size and serum malondialdehyde, interleukin-1β, and tumor necrosis factor-α than those of the sham group. Treatment with oleuropein prevented the increase of these variables. The results show that oleuropein attenuates the progression of heart failure, possibly by antioxidative and antiinflammatory effects.
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References
Andreadou I et al (2006) The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits. J Nutr 136:2213–2219
Andreadou I et al (2007) Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress. J Mol Cell Cardiol 42:549–558. doi:10.1016/j.yjmcc.2006.11.016
Andreadou I et al (2014) Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism. J Mol Cell Cardiol 69:4–16. doi:10.1016/j.yjmcc.2014.01.007
Aurigemma GP, Zile MR, Gaasch WH (2006) Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function. Circulation 113:296–304. doi:10.1161/CIRCULATIONAHA.104.481465
Bozkurt B, Mann DL, Deswal A (2010) Biomarkers of inflammation in heart failure. Heart Fail Rev 15:331–341. doi:10.1007/s10741-009-9140-3
Ertl G, Frantz S (2005) Healing after myocardial infarction. Cardiovasc Res 66:22–32. doi:10.1016/j.cardiores.2005.01.011
Ferrari R et al (1998) Oxidative stress during myocardial ischaemia and heart failure. Eur Heart J 19(Suppl B):B2–11
Gandhi SK, Powers JC, Nomeir AM, Fowle K, Kitzman DW, Rankin KM, Little WC (2001) The pathogenesis of acute pulmonary edema associated with hypertension. N Engl J Med 344:17–22. doi:10.1056/NEJM200101043440103
Garjani A, Andalib S, Biabani S, Soraya H, Doustar Y, Maleki-Dizaji N (2011) Combined atorvastatin and coenzyme Q10 improve the left ventricular function in isoproterenol-induced heart failure in rat. Eur J Pharmacol 666:135–141. doi:10.1016/j.ejphar.2011.04.061
Giordano FJ (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115:500–508. doi:10.1172/JCI24408
Hegewisch S, Weh HJ, Hossfeld DK (1990) TNF-induced cardiomyopathy. Lancet 335:294–295
Huang CL, Sumpio BE (2008) Olive oil, the mediterranean diet, and cardiovascular health. J Am Coll Surg 207:407–416. doi:10.1016/j.jamcollsurg.2008.02.018
Huang CX et al (2009) Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect. Peptides 30:2286–2291. doi:10.1016/j.peptides.2009.09.004
Janahmadi Z, Nekooeian AA, Moaref AR, Emamghoreishi M (2015) Oleuropein offers cardioprotection in rats with acute myocardial infarction. Cardiovascular toxicology 15:61–68. doi:10.1007/s12012-014-9271-1
Keys A (1980) Seven countries : a multivariate analysis of death and coronary heart disease / Ancel Keys, with Christ Aravanis [et al.]. Harvard University Press, Cambridge, Mass
Keys A (1997) Coronary heart disease in seven countries. 1970. Nutrition 13:250–252 discussion 249, 253
Kim Y, Choi Y, Park T (2010) Hepatoprotective effect of oleuropein in mice: mechanisms uncovered by gene expression profiling. Biotechnol J 5:950–960. doi:10.1002/biot.201000068
Klug D, Robert V, Swynghedauw B (1993) Role of mechanical and hormonal factors in cardiac remodeling and the biologic limits of myocardial adaptation. Am J Cardiol 71:46A–54A
Kumar D, Lou H, Singal PK (2002) Oxidative stress and apoptosis in heart dysfunction. Herz 27:662–668. doi:10.1007/s00059-002-2430-3
Li C, Gao Y, Tian J, Xing Y, Zhu H, Shen J (2012) Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarction. Food Chem Toxicol 50:1432–1438. doi:10.1016/j.fct.2012.01.024
Mak S, Newton GE (2001) The oxidative stress hypothesis of congestive heart failure: radical thoughts. Chest 120:2035–2046
Manna C, Migliardi V, Golino P, Scognamiglio A, Galletti P, Chiariello M, Zappia V (2004) Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. J Nutr Biochem 15:461–466. doi:10.1016/j.jnutbio.2003.12.010
McAlpine HM, Morton JJ, Leckie B, Rumley A, Gillen G, Dargie HJ (1988) Neuroendocrine activation after acute myocardial infarction. Br Heart J 60:117–124
Menotti A et al (1997) Changes in population cholesterol levels and coronary heart disease deaths in seven countries. Eur Heart J 18:566–571
Mercanoglu GO, Pamukcu B, Safran N, Mercanoglu F, Fici F, Gungor M (2010) Nebivolol prevents remodeling in a rat myocardial infarction model: an echocardiographic study. Anadolu Kardiyol Derg 10:18–27
Nekooeian AA, Khalili A, Khosravi MB (2014) Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. J Asian Nat Prod Res 16:953–962. doi:10.1080/10286020.2014.924510
Nian M, Lee P, Khaper N, Liu P (2004) Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res 94:1543–1553. doi:10.1161/01.RES.0000130526.20854.fa
Omar SH (2010) Oleuropein in olive and its pharmacological effects. Sci Pharm 78:133–154. doi:10.3797/scipharm.0912-18
Parveen A, Babbar R, Agarwal S, Kotwani A, Fahim M (2011) Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats. Cardiovasc Toxicol 11:48–57. doi:10.1007/s12012-010-9099-2
Petroni A, Blasevich M, Salami M, Papini N, Montedoro GF, Galli C (1995) Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thromb Res 78:151–160
Radovanovic S et al (2012) Markers of oxidative damage and antioxidant enzyme activities as predictors of morbidity and mortality in patients with chronic heart failure. J Card Fail 18:493–501. doi:10.1016/j.cardfail.2012.04.003
Romero M et al (2016) Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats. Food Funct 7:584–593. doi:10.1039/c5fo01101a
Sola S, Mir MQ, Lerakis S, Tandon N, Khan BV (2006) Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. J Am Coll Cardiol 47:332–337. doi:10.1016/j.jacc.2005.06.088
Srikanth G, Prakash P, Tripathy N, Dikshit M, Nityanand S (2009) Establishment of a rat model of myocardial infarction with a high survival rate: a suitable model for evaluation of efficacy of stem cell therapy. J Stem Cells Regen Med 5:30–36
Wojciechowska C, Romuk E, Tomasik A, Skrzep-Poloczek B, Nowalany-Kozielska E, Birkner E, Jachec W (2014) Oxidative stress markers and C-reactive protein are related to severity of heart failure in patients with dilated cardiomyopathy. Mediat Inflamm 2014:147040. doi:10.1155/2014/147040
Yancy CW et al (2013) 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 62:e147–e239. doi:10.1016/j.jacc.2013.05.019
Zarrouk-Mahjoub S et al (2016) Pro- and anti-inflammatory cytokines in post-infarction left ventricular remodeling. Int J Cardiol 221:632–636. doi:10.1016/j.ijcard.2016.07.073
Zarzuelo A, Duarte J, Jimenez J, Gonzalez M, Utrilla MP (1991) Vasodilator effect of olive leaf. Planta Med 57:417–419. doi:10.1055/s-2006-960138
Zhang YJ et al (2014) Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: role of autophagy. Clin Exp Pharmacol Physiol 41:995–1002. doi:10.1111/1440-1681.12309
Zhou F, Hu SJ, Mu Y (2007) Protection effect of Wenxin Keli on isoproterenol induced heart failure in rats. Zhongguo Zhong Yao Za Zhi 32:1676–1679
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This work was supported by a grant (91-6357) from the Vice Presidency for Research, Shiraz University of Medical Sciences.
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Janahmadi, Z., Nekooeian, A.A., Moaref, A.R. et al. Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects. Naunyn-Schmiedeberg's Arch Pharmacol 390, 245–252 (2017). https://doi.org/10.1007/s00210-016-1323-6
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DOI: https://doi.org/10.1007/s00210-016-1323-6