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PEG-mesoporous material modified by superparamagnetic nanoparticles as a delivery system of cefotaxime

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Abstract

The fight against infectious bacterial diseases has been taking major steps forward by designing new nanodrugs and nanoscale biological carriers with unique physicochemical properties. Here, polyethylene glycol (PEG)-silica mesoporous material/superparamagnetic CuFe2O4 nanoparticle nanocomposite was synthesized using a facile chemical approach, and proposed as a carrier for the delivery of cefotaxime (CTX) drug. The resulting nanocomposite material and nanocomposite CTX drug carrier were characterized by different techniques. Antibacterial activity of the nanocomposite drug carrier was investigated against E.coli and S. aureus bacteria, and compared with that of commercial CTX drug. It was found that the minimum inhibitory concentrations of the nanocomposite drug carrier (1.25 and 5 μg/mL) were significantly less than those of the commercial drug (10 and 80 μg/mL) against the bacteria. Furthermore, enhanced performance of the nanocomposite CTX carrier for both the Gram-negative and Gram-positive bacteria was evidenced.

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Availability of data and material

The data will be available upon reasonable request.

Code availability

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Abbreviations

CTX:

Cefotaxime

NPs:

Nanoparticles

PEG:

Polyethylene glycol

SMM:

Silica mesoporous material

CuFO:

CuFe2O4 NPs

MIC:

Minimum inhibitory concentration

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Funding

This study was supported by grants from the University of Kashan and the Graduate University of Advanced Technology of Kerman.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran

    Amin Salehi & Mohsen Behpour

  2. Department of Environment, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Daryoush Afzali

Authors
  1. Amin Salehi
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  2. Mohsen Behpour
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  3. Daryoush Afzali
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Correspondence to Amin Salehi.

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By submitting the manuscript, the authors understand that the material presented in this manuscript has not been published before, nor has it been submitted for publication to another journal. The corresponding author attests that this study has been approved by all the co-authors concerned.

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Communicated by Erko Stackebrandt.

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Salehi, A., Behpour, M. & Afzali, D. PEG-mesoporous material modified by superparamagnetic nanoparticles as a delivery system of cefotaxime. Arch Microbiol 204, 322 (2022). https://doi.org/10.1007/s00203-022-02937-3

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  • DOI: https://doi.org/10.1007/s00203-022-02937-3

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