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Contribution of genetic polymorphisms of interleukins IL1B-511 C/T, IL1RN VNTR, IL6-174 G/C, and IL8-251 A/T in gastric lesions: gender and Helicobacter pylori genes matter

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Abstract

Stomach pathologies develop in a complex interaction between the host’s genetic background and H. pylori virulent genes. Thus, our study aimed to compare active chronic gastritis (ACG), and intestinal metaplasia (IM) with inactive chronic gastritis (ICG), according to interleukin polymorphisms of IL6-174 G/C, IL8-251 A/T, IL1β-511 C/T, and IL1RN VNTR taking into account patient gender and H. pylori genotypes. Interleukin polymorphisms were determined by RFLP-PCR and H. pylori genotype by PCR. IL6-174 GC and IL8-251 T allele showed a protective effect in women against ACG development and, conversely, IL8-251 polymorphism showed a risk for men. More virulent H. pylori strains were associated with the IL8-251 T allele and IL1β-511 T allele in the AGC, and the vacA m1 allele and cagE gene from H. pylori was associated with the IM. Analysis of the progression of gastric lesions must take into account host variability genetic associated with genes H. pylori due to the relation between the virulent H. pylori genes and more severe gastric lesions, besides the relevance to the gender to IL6-174 and IL8-251 polymorphisms.

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Acknowledgements

We are grateful to Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP) for the support financial and to the Hospital Universitário Walter Cantídeo (HUWC) and, Hospital Geral de Fortaleza (HGF).

Funding

We are grateful to Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP) for the support financial and to the hospitals.

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Authors and Affiliations

  1. Department of Pathology and Forensic Medicine, Federal University of Ceará, Coronel Nunes de Melo Street, 1315, Rodolfo Teófilo, Fortaleza, CE, Brazil

    Morgana Maria de Oliveira Barboza, Francivandi Coelho Barbosa, Ana Paula Santos do Carmo, Fernanda Capelo Barroso & Silvia Helena Barem Rabenhorst

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  1. Morgana Maria de Oliveira Barboza
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  2. Francivandi Coelho Barbosa
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  3. Ana Paula Santos do Carmo
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  4. Fernanda Capelo Barroso
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  5. Silvia Helena Barem Rabenhorst
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Contributions

Morgana Maria de Oliveira Barboza: formal analysis, investigation, and writing—original draft preparation. Francivandi Coelho Barbosa: data curation and investigation. Ana Paula Santos do Carmo: data curation and investigation. Fernanda Capelo Barroso: investigation. Silvia Helena Baren Rabenhorst: conceptualization, methodology, validation, resources, writing—review and editing, supervision, project administration, and funding acquisition.

Corresponding author

Correspondence to Silvia Helena Barem Rabenhorst.

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Ethics approval

The study was approved by the Ethics Committees (047.06.09 and 07,014/10).

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Informed consent for participation in the study and publication was obtained from all subjects’ participants.

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Informed consent for participation in the study and publication was obtained from all subjects’ participants.

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Communicated by Erko Stackebrandt.

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Barboza, M.M.d., Barbosa, F.C., do Carmo, A.P.S. et al. Contribution of genetic polymorphisms of interleukins IL1B-511 C/T, IL1RN VNTR, IL6-174 G/C, and IL8-251 A/T in gastric lesions: gender and Helicobacter pylori genes matter. Arch Microbiol 203, 3467–3472 (2021). https://doi.org/10.1007/s00203-021-02281-y

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  • DOI: https://doi.org/10.1007/s00203-021-02281-y

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