A fragility fracture signals underlying osteoporosis, a condition that is greatly underdiagnosed and undertreated. The burden of osteoporosis is expected to increase as populations age, and the number of individuals at risk of fragility fractures worldwide is estimated to increase more than twofold from the 158 million it was in 2010 to 319 million by the year 2040 [1]. Unfortunately, even the patients at highest risk who have already fractured are often not treated [2, 3]. The situation, in the Asia Pacific region, which is home to 4.5 billion people and comprises 71 countries and regions [4] is going to be even more overwhelming. The population aged over 65 years in Asia alone is projected to more than quadruple by 2050, and to further grow by almost sixfold by the year 2100 [5]. It is predicted that in the year 2050, over half of the world’s hip fractures will be in the Asia Pacific region [6]. This will come at great cost; treating a single hip fracture represents approximately 19% of Asia Pacific’s regional per-head gross domestic product each year even currently [7, 8].

Despite the enormous and growing burden of fragility fractures, osteoporosis is being dangerously ignored as it competes with other diseases for scarce health-care resources and recognition. The disease remains greatly under-diagnosed and under-treated, and health professional training and service provision is suboptimal in many countries of the Asia Pacific. – Professor John Kanis, Honorary President, International Osteoporosis Foundation (IOF) at the launch of the Asia Pacific Regional Audit Report, 2013 [9]

This statement comes as no surprise since the Asia Pacific region has within it, populations with tremendously diverse socio-economic and cultural norms and countries with vastly different health systems and resources. The healthcare responses to osteoporosis are thus fragmented and unequal. Added challenges include variations in knowledge and disease awareness, limited diagnostic facilities and lack of health professionals trained in osteoporosis management in several countries in the region [3, 10, 11].

The Asia Pacific Consortium on Osteoporosis

The Asia Pacific Consortium on Osteoporosis (APCO), a non-partisanal and apolitical organization, was established in May 2019 with the vision of reducing the burden of osteoporosis and fragility fractures in the Asia Pacific region. APCO hopes to achieve this vision by engaging with relevant stakeholders including healthcare providers, policy makers and the public, to help develop and implement country and region-specific programs for the prevention and treatment of osteoporosis and its complication of fragility fractures in the Asia Pacific region.

The idea for developing a consortium on osteoporosis was inspired by similar work in another area of clinical medicine. The primary aim at the time of the formation of APCO was to gather a group of experts whose work to date has demonstrated their passion and commitment to advancing the cause of osteoporosis in their respective countries and/or in the region. These individuals were identified and invited by the Chairperson to contribute their expertise to APCO. APCO members voluntarily contribute their time and expertise to it. The strength of APCO lies in the diversity of its members, with it creating a forum for the exchange of ideas between experts working in very different healthcare systems and clinical settings. APCO is also ably supported in its functions by a four-member project management team.

APCO currently has 39 experts from 19 countries and regions within the Asia Pacific. The International Osteoporosis Foundation (IOF) is represented by its Chief Executive Officer. We hope to ultimately include osteoporosis experts from all the countries and regions in the Asia Pacific. APCO endeavours to support and empower healthcare professionals to improve osteoporosis care, and its members will serve as a bridge between APCO and their colleagues, thought leaders, osteoporosis societies and policy makers within their respective countries.

The priority initiative of APCO

Adherence to evidence-based management recommendations is associated with improvement in patient outcomes [12]. Strategies employed to improve the implementation and use of osteoporosis guidelines have also been shown to result in management plans becoming aligned with best practice [13]. APCO has identified the following key gaps in osteoporosis screening, diagnosis and in consistent delivery of osteoporosis care in the Asia Pacific region:

  • Clinical guidelines relating to osteoporosis in the Asia Pacific are either unavailable and if they are, are heterogenous in terms of their scope and recommendations made.

  • A significant proportion of current national guidelines are not current, having been published more than 10 years ago.

  • There is a paucity of information on adherence with national guidelines in day-to-day clinical practice across the region.

Therefore, APCO’s first project is to develop and implement a Pan-Asia Pacific framework (“The Framework”) that provides clinical standards for the screening, diagnosis and management of osteoporosis in groups at high risk of fracture. Broad endorsement of the Framework will be sought from national and international organizations before publication of the Framework. Subsequently, APCO will also provide tools and templates to support its members to deliver the Framework at the local level. The long-term goal after publication of the Framework is to develop APCO into a free-standing entity with a formalized legal, governance and organizational structure.

The nitty-gritties of developing The Framework

The framework focuses on identifying and treating a broad range of high-risk groups in a tiered manner. The highest priority group is older men and post-menopausal women with a prevalent fragility fracture. The other groups that are included in the Framework are people taking medications and/or have medical conditions that predispose them to bone loss or fragility fracture, people deemed to be at high risk based on country-specific fracture intervention thresholds, those aged 70 years or over and those below 70 years of age with other risk factors for fragility fracture, such as a history of frequent falls.

A stepwise approach informed by analogous approaches undertaken elsewhere [14] is being employed to develop the Framework. All osteoporosis and fracture prevention guidelines published in the last decade in the Asia Pacific region have been identified and those in other languages have been translated into English. A comparative analysis of the guidelines with special attention to the ones published in the last quinquennium has been done using a template based on a modified “5IQ” approach. The “5IQ” approach underpinned the development of clinical standards for Fracture Liaison Services (FLS) in New Zealand [15] and the UK [16]. Each guideline that was included in the comparative analysis was thoroughly evaluated to see whether the following 6 parameters were included in it:

  • Identification: a statement regarding which individuals are identified as high risk

  • Investigation: a description of the types of investigations recommended to delineate the cause of osteoporosis

  • Information: a description of the types of education that are provided

  • Initiation: a description of pharmacological and falls prevention interventions

  • Integration: a statement on the need for integration between primary and secondary care

  • Quality: a description of professional development, audit and peer-review activities

The comparative analysis has now been completed. The minimum standards of care that will form the framework will be generated through a Delphi process [17] to identify areas of consensus and discord amongst the APCO members.

The Framework will serve as a platform upon which new national clinical guidelines in the Asia Pacific can be developed or existing guidelines be revised, in a standardized fashion. Practical adoption of the clinical standards at each national level is the ultimate purpose for developing the Framework. Notably, the Framework will be a distilled guidance document with minimum clinical standards for best practice, not a prescriptive guideline.

To address the heterogeneity across the region, the Framework and its implementation will be modular, allowing the user to select the most appropriate content depending on the stage or level already attained by their facility or country. A stepwise path for progression towards best practice will be set, and each facility will be encouraged to progress to the next level as they are able to. This modular approach is similar to the Capture the Fracture® Best Practice Framework that has been implemented by the IOF and to the patient-level key performance indicators recently endorsed by the National Osteoporosis Foundation and the Fragility Fracture Network [18, 19].

For each country or region, an assessment of the differences between the core recommendations of current national clinical guidelines and the standards advocated in the Framework will inform the improvements that need to be made at the national /regional level. This can then serve as an impetus to advocate for and to drive policy change. To realise these changes, APCO will be collaborating with national, regional and international societies and organizations such as the Asian Federation of Osteoporosis Societies, the Fragility Fracture Network, the Asia Pacific Fragility Fracture Alliance and the International Osteoporosis Foundation and educational initiatives such as the Asia Pacific Bone Academy [20]. We envision these collaborations to be seamless as many of the APCO members are already part of these organisations and initiatives.

Implementation of the Framework and its effectiveness needs to be measured for it to be meaningful. The medical centres where APCO members work at will serve as “pathfinder” sites for their respective countries. Immediately after publication of the Framework, an audit will be conducted at pathfinder sites to assess how congruent their own standards of care are with those advocated in the Framework. A follow-up audit can then be conducted by pathfinder sites 12 months after the baseline audit, to assess the impact of the Framework.

In the words of the Chinese philosopher, Lao Tzu (老子《道德經), “The journey of a thousand miles starts with one step” (“「千里之行, 始於足下」”). There is no doubt that there is a long way to go to reduce the burden of osteoporosis and fragility fractures in the Asia Pacific region. The development of the Framework of minimum clinical standards is the first step to improve the screening, diagnosis and management of osteoporosis in groups at high risk of fracture in this region. APCO’s intention is not to ignore current stark realities and the challenges and limitations that make osteoporosis care difficult in such a vast and diversely populated area such as the Asia Pacific, but to provide a benchmark to which organizations and health care facilities can aspire. The principles underlying the formation and functioning of APCO could potentially be adopted by other regions in the world. It is hoped that each facility and progressively each country will follow our aspirational path towards best practice, ultimately making osteoporosis a national, regional and international health priority to avert the “perfect storm” [3] that is brewing.