Abstract
Introduction and hypothesis
Obesity and overweight are strongly associated with stress and urgency urinary incontinence, and weight loss has been associated with improvement in urinary incontinence. We aimed to measure pooled effect sizes for different weight loss procedures on incontinence-specific quality of life and incontinence cure rate in a systematic review and meta-analysis.
Methods
MEDLINE, Embase and the Cochrane library were searched using a pre-defined strategy for relevant cohort studies. Random effects meta-analyses were conducted for the weighted mean difference for urinary quality of life scores and weighted overall pooled estimates for proportions of women cured. We explored heterogeneity using meta-regression, testing the type of bariatric surgery and change in BMI as predictors of effect size. The studies were categorised as either low or high risk of bias using a novel instrument specifically designed for longitudinal symptom research studies.
Results
Twenty-three studies (n = 3,225) were included. Incontinence-specific quality of life scores were improved by 14% (weighted mean difference = −14.79; CI = −18.47 to −11.11; I2 = 87.1%); the proportion of women cured of any urinary incontinence was 59% (95% CI = 51 to 66%) and the proportion of women cured of stress urinary incontinence was 55% (95% CI = 40 to 70%).
Conclusions
Bariatric surgery results in clinically meaningful improvements in incontinence-specific quality of life. Current data are limited by both short-term follow-up and unexplained heterogeneity among studies.
Similar content being viewed by others
References
Colquitt JL, Pickett K, Loveman E, Frampton GK. Surgery for weight loss in adults. Cochrane Database Syst Rev. 2014;(8):CD003641. https://doi.org/10.1002/14651858.CD003641.pub4.
Vaughan CP, Auvinen A, Cartwright R, Johnson TM II, Tahtinen RM, Ala-Lipasti MA, et al. Impact of obesity on urinary storage symptoms: results from the FINNO study. J Urol. 2013;189(4):1377–82. https://doi.org/10.1016/j.juro.2012.10.058.
Hunskaar S. A systematic review of overweight and obesity as risk factors and targets for clinical intervention for urinary incontinence in women. Neurourol Urodyn. 2008;27(8):749–57. https://doi.org/10.1002/nau.20635.
Osborn DJ, Strain M, Gomelsky A, Rothschild J, Dmochowski R. Obesity and female stress urinary incontinence. Urology. 2013;82(4):759–63. https://doi.org/10.1016/j.urology.2013.06.020.
Vissers D, Neels H, Vermandel A, De Wachter S, Tjalma WA, Wyndaele JJ, et al. The effect of non-surgical weight loss interventions on urinary incontinence in overweight women: a systematic review and meta-analysis. Obes Rev. 2014;15(7):610–7. https://doi.org/10.1111/obr.12170.
National Institute for Health and Care Excellence. Urinary incontinence in women: management (CG171). 2013. Available at https://www.nice.org.uk/guidance/cg171.
European Association of Urology (EAoU). Urinary incontinence 2017. 2017. Available at http://uroweb.org/guideline/urinary-incontinence.
Gozukara YM, Akalan G, Tok EC, Aytan H, Ertunc D. The improvement in pelvic floor symptoms with weight loss in obese women does not correlate with the changes in pelvic anatomy. Int Urogynecol J. 2014;25(9):1219–25. https://doi.org/10.1007/s00192-014-2368-z.
Subak LL, Wing R, West DS, Franklin F, Vittinghoff E, Creasman JM, et al. Weight loss to treat urinary incontinence in overweight and obese women. N Engl J Med. 2009;360(5):481–90. https://doi.org/10.1056/NEJMoa0806375.
Lian W, Zheng Y, Huang H, Chen L, Cao B. Effects of bariatric surgery on pelvic floor disorders in obese women: a meta-analysis. Arch Gynecol Obstet. 2017;296(2):181–9. https://doi.org/10.1007/s00404-017-4415-8.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/bmj.b2535.
Bump RC, Sugerman HJ, Fantl JA, McClish DK. Obesity and lower urinary tract function in women: effect of surgically induced weight loss. Am J Obstet Gynecol. 1992;167(2):392–7; discussion 397–399.
Burgio KL, Richter HE, Clements RH, Redden DT, Goode PS. Changes in urinary and fecal incontinence symptoms with weight loss surgery in morbidly obese women. Obstet Gynecol. 2007;110(5):1034–40. https://doi.org/10.1097/01.AOG.0000285483.22898.9c.
Castro LA, Sobottka W, Baretta G, Freitas AC. Effects of bariatric surgery on pelvic floor function. Arq Bras Cir Dig. 2012;25(4):263–8.
Cuicchi D, Lombardi R, Cariani S, Leuratti L, Lecce F, Cola B. Clinical and instrumental evaluation of pelvic floor disorders before and after bariatric surgery in obese women. Surg Obes Relat Dis. 2013;9(1):69–75. https://doi.org/10.1016/j.soard.2011.08.013.
Daucher JA, Ellison RE, Lowder JL. Pelvic support and urinary function improve in women after surgically induced weight reduction. Female Pelvic Med Reconstr Surg. 2010;16(5):263–7. https://doi.org/10.1097/SPV.0b013e3181eedb30.
Kuruba R, Almahmeed T, Martinez F, Torrella TA, Haines K, Nelson LG, et al. Bariatric surgery improves urinary incontinence in morbidly obese individuals. Surg Obes Relat Dis. 2007;3(6):586–90; discussion 590–581. https://doi.org/10.1016/j.soard.2007.08.007.
Knoepp LR, Semins MJ, Wright EJ, Steele K, Shore AD, Clark JM, et al. Does bariatric surgery affect urinary incontinence? Urology. 2013;82(3):547–51. https://doi.org/10.1016/j.urology.2013.04.042.
Laungani RG, Seleno N, Carlin AM. Effect of laparoscopic gastric bypass surgery on urinary incontinence in morbidly obese women. Surg Obes Relat Dis. 2009;5(3):334–8. https://doi.org/10.1016/j.soard.2008.12.003.
McDermott CD, Terry CL, Mattar SG, Hale DS. Female pelvic floor symptoms before and after bariatric surgery. Obes Surg. 2012;22(8):1244–50. https://doi.org/10.1007/s11695-012-0592-5.
O’Boyle CJ, O’Sullivan OE, Shabana H, Boyce M, O’Reilly BA. The effect of bariatric surgery on urinary incontinence in women. Obes Surg. 2016;26(7):1471–8. https://doi.org/10.1007/s11695-015-1969-z.
Olivera CK, Herron DM, Kini SU, Vardy MD, Ascher-Walsh CJ, Garely AD, et al. Long-term quality of life and pelvic floor dysfunction after bariatric surgery. Am J Obstet Gynecol. 2012;207(5):431.e1–4. https://doi.org/10.1016/j.ajog.2012.06.041.
Palleschi G, Pastore AL, Rizzello M, Cavallaro G, Silecchia G, Carbone A. Laparoscopic sleeve gastrectomy effects on overactive bladder symptoms. J Surg Res. 2015;196(2):307–12. https://doi.org/10.1016/j.jss.2015.03.035.
Ranasinghe WK, Wright T, Attia J, McElduff P, Doyle T, Bartholomew M, et al. Effects of bariatric surgery on urinary and sexual function. BJU Int. 2011;107(1):88–94. https://doi.org/10.1111/j.1464-410X.2010.09509.x.
Scozzari G, Rebecchi F, Giaccone C, Chiaro P, Mistrangelo M, Morino M. Bariatric surgery improves urinary incontinence but not anorectal function in obese women. Obes Surg. 2013;23(7):931–8. https://doi.org/10.1007/s11695-013-0880-8.
Shimonov M, Groutz A, Schachter P, Gordon D. Is bariatric surgery the answer to urinary incontinence in obese women? Neurourol Urodyn. 2015;36(1):184–7. https://doi.org/10.1002/nau.22909.
Subak LL, King WC, Belle SH, Chen JY, Courcoulas AP, Ebel FE, et al. Urinary incontinence before and after bariatric surgery. JAMA Intern Med. 2015;175(8):1378–87. https://doi.org/10.1001/jamainternmed.2015.2609.
Vella VL, Jaffe W, Lidicker J, Meilahn J, Dandolu V. Prevalence of urinary symptoms in morbidly obese women and changes after bariatric surgery. J Reprod Med. 2009;54(10):597–602.
Wasserberg N, Petrone P, Haney M, Crookes PF, Kaufman HS. Effect of surgically induced weight loss on pelvic floor disorders in morbidly obese women. Ann Surg. 2009;249(1):72–6. https://doi.org/10.1097/SLA.0b013e31818c7082.
Whitcomb EL, Horgan S, Donohue MC, Lukacz ES. Impact of surgically induced weight loss on pelvic floor disorders. Int Urogynecol J. 2012;23(8):1111–6. https://doi.org/10.1007/s00192-012-1756-5.
Tikkinen KAO, Busse JW, Guyatt GH. Tool to assess risk of bias in observational studies of natural history of medical symptoms/conditions in general populations. Available at https://www.evidencepartners.com/wp-content/uploads/2017/09/Tool-to-Assess-Risk-of-Bias-in-Cohort-Studies.pdf.
Nyaga VN, Arbyn M, Aerts M. Metaprop: a Stata command to perform meta-analysis of binomial data. Arch Public Health. 2014;72(1):39. https://doi.org/10.1186/2049-3258-72-39.
Romero-Talamas H, Unger CA, Aminian A, Schauer PR, Barber M, Brethauer S. Comprehensive evaluation of the effect of bariatric surgery on pelvic floor disorders. Surg Obes Relat Dis. 2016;12(1):138–43. https://doi.org/10.1016/j.soard.2015.08.499.
Deitel M, Stone E, Kassam HA, Wilk EJ, Sutherland DJ. Gynecologic-obstetric changes after loss of massive excess weight following bariatric surgery. J Am Coll Nutr. 1988;7(2):147–53.
Frigg A, Peterli R, Peters T, Ackermann C, Tondelli P. Reduction in co-morbidities 4 years after laparoscopic adjustable gastric banding. Obes Surg. 2004;14(2):216–23. https://doi.org/10.1381/096089204322857591.
Sjostrom L. Review of the key results from the Swedish obese subjects (SOS) trial—a prospective controlled intervention study of bariatric surgery. J Intern Med. 2013;273(3):219–34. https://doi.org/10.1111/joim.12012.
Chang SH, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA. The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003–2012. JAMA Surg. 2014;149(3):275–87. https://doi.org/10.1001/jamasurg.2013.3654.
Khullar V, Sexton CC, Thompson CL, Milsom I, Bitoun CE, Coyne KS. The relationship between BMI and urinary incontinence subgroups: results from EpiLUTS. Neurourol Urodyn. 2014;33(4):392–9. https://doi.org/10.1002/nau.22428.
Roberson EN, Gould JC, Wald A. Urinary and fecal incontinence after bariatric surgery. Dig Dis Sci. 2010;55(9):2606–13.https://doi.org/10.1007/s10620-010-1190-9
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
None.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Purwar, B., Cartwright, R., Cavalcanti, G. et al. The impact of bariatric surgery on urinary incontinence: a systematic review and meta-analysis. Int Urogynecol J 30, 1225–1237 (2019). https://doi.org/10.1007/s00192-018-03865-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00192-018-03865-x