Abstract
Purpose
To evaluate the incidence, morphology, and associated complications of medial cortical hinge fractures after lateral closing wedge distal femoral osteotomy (LCW-DFO) for varus malalignment and to identify constitutional and technical factors predisposing for hinge fracture and consecutive complications.
Methods
Seventy-nine consecutive patients with a mean age of 47 ± 12 years who underwent LCW-DFO for symptomatic varus malalignment at the authors’ institution between 01/2007 and 03/2018 with a minimum of 2-year postoperative time interval were enrolled in this retrospective observational study. Demographic and surgical data were collected. Measurements evaluating the osteotomy cut (length, wedge height, hinge angle) and the location of the hinge (craniocaudal and mediolateral orientation, relation to the adductor tubercle) were conducted on postoperative anterior–posterior knee radiographs and the incidence and morphology of medial cortical hinge fractures was assessed. A risk factor analysis of constitutional and technical factors predisposing for the incidence of a medial cortical hinge fracture and consecutive complications was conducted.
Results
The incidence of medial cortical hinge fractures was 48%. The most frequent morphological type was an extension fracture type (68%), followed by a proximal (21%) and distal fracture type (11%). An increased length of the osteotomy in mm (53.1 ± 10.9 vs. 57.7 ± 9.6; p = 0.049), an increased height of the excised wedge in mm (6.5 ± 1.9 vs. 7.9 ± 3; p = 0.040) as well as a hinge location in the medial sector of an established sector grid (p = 0.049) were shown to significantly predispose for the incidence of a medial cortical hinge fracture. The incidence of malunion after hinge fracture (14%) was significantly increased after mediolateral dislocation of the medial cortical bone > 2 mm (p < 0.05).
Conclusion
Medial cortical hinge fractures after LCW-DFO are a common finding. An increased risk of sustaining a hinge fracture has to be expected with increasing osteotomy wedge height and a hinge position close to the medial cortex. Furthermore, dislocation of a medial hinge fracture > 2 mm was associated with malunion and should, therefore, be avoided.
Level of evidence
Prognostic study; Level IV.
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Introduction
Varus malalignment has been demonstrated to play an important role in development of medial knee joint cartilage degeneration and thus predispose for medial knee osteoarthritis [11, 18, 29, 45, 52]. Hence, surgical correction of varus malalignment by valgus producing osteotomy to unload the medial compartment is indicated in moderate medial knee osteoarthritis [5, 18] or in combination with cartilage regenerative [1, 19] or meniscus replacing procedures [26, 27]. While historically, correction of varus alignment has been predominantly described via high tibial osteotomy (HTO) [5, 7, 16, 18, 22,23,24, 28, 30, 33, 34, 40, 49], the dogma of an isolated tibial based deformity is recently being reevaluated [13, 37]. To prevent joint line obliquity that negatively affects joint biomechanics [2, 37, 42, 46, 48, 51], it was shown that in 71% of the cases, a (concomitant) femoral correction is required [13]. While the favourable postoperative outcomes reported in the literature have increased the popularity of the femoral lateral closing (CW) wedge technique [2, 15, 25, 35, 43, 44], recent investigations are aimed to identify reasons for failures [13]. Hinge fractures in distal femoral osteotomies (DFO)—resulting in increased rotational movement across the osteotomy plane [3, 41]—may explain a considerable number of delayed unions or losses of correction reported [4, 6, 8, 9, 14, 25, 54]. While technical factors and vulnerable anatomical zones associated with an increased risk of hinge fractures have been reported for HTO [16, 31,32,33, 49], medial closing wedge (MCW) DFO [21, 39] and LOW-DFO [53], the only report investigating hinge fractures in LCW-DFO to-date was performed in a relatively small collective and could not identify any risk factors [36].
Thus, the primary objective of this retrospective observational study was to evaluate the incidence, morphology, and associated complications of medial cortical hinge fractures after LCW-DFO. The secondary objective was to identify demographic, constitutional or technical factors predisposing for a medial cortical hinge fracture and consecutive complications. It was hypothesised that medial cortical fracture in LCW-DFO is common, results in complications, and that a medial hinge position and a high degree of correction would increase the risk of sustaining a medial cortical hinge fracture.
Methods
This was an Institutional-Review-Board (Technical University of Munich, No. 6/20S) -approved retrospective observational study. Ninety consecutive patients who underwent LCW-DFO for symptomatic varus malalignment between 01/2007 and 03/2018 were screened for eligibility. Preoperative anterior–posterior (AP) hip-knee-ankle radiographs and standard lateral radiographs as well as standard postoperative AP and lateral knee radiographs, comprehensive medical records and a minimum of 2 years of postoperative time interval were required for inclusion. Previous osteotomies, posttraumatic deformities of the distal femur, (concomitant) axis correction in the sagittal plane as well as a malrotation of the postoperative AP knee radiograph (resulting in a misprojection of the bony landmarks) were defined as exclusion criteria. Eleven patients meeting the exclusion criteria (2 severely malrotated radiographs, 1 posttraumatic deformity, 8 concomitant correction in the sagittal plane) were excluded. A total of 79 patients (mean age: 47 ± 12 years, male sex: 66%) were included in the final analysis. A LCW-DFO was performed for medial compartment osteoarthritis in 67 (85%), an osteochondral defect in the medial compartment in 9 (11%), and chronic ligamentous insufficiency in 3 (4%) cases as the respective main diagnosis. Detailed characteristics of the patient collective are presented in Table 1.
Indications and surgical technique
Varus malalignment was analysed on AP hip–knee–ankle radiographs prior to surgery and the osteotomy was planned employing mediCAD® software (mediCAD Hectec GmbH, Altdorf, Germany). An overcorrection of the mechanical leg axis crossing the centre of the tibial plateau laterally (55–65% from medial to lateral, depending on the primary diagnosis) was sought and the required correction (in mm) was calculated consecutively. In case, the mechanical lateral distal femur angle (MLDFA) fell below 85° in planning, a concomitant HTO was indicated to avoid excessive postoperative joint line obliquity.
Following lateral distal femoral skin incision and longitudinal split of the iliotibial band, the femoral metaphysis was carefully exposed, bluntly dissecting the vastus lateralis muscle from the intermuscular septum. The biplanar osteotomy planes were marked and a bicortical frontal osteotomy was performed. Next, four axial K-wires, marking the osteotomy wedge to be excised proximally and distally, were placed for axial osteotomy. Consecutively, lateral osteotomy preserving the medial cortex was performed with the hinge located at a 0.5–1 cm distance from the medial cortex. The osteotomy gap was carefully closed applying moderate valgus stress and axial compression. Following temporary fixation, mechanical correction was controlled via fluoroscopy as previously described [12]. A locking compression plate—either PEEK-Power™ Plate (Arthrex Inc., Naples, FL, USA) or TomoFix™ Plate (DePuy Synthes, Raynham, MA, USA)—was used to secure the osteotomy. The postoperative rehabilitation program started on the first postoperative day and depended on the primary diagnosis and the concomitant procedures. For osteotomy with or without ligamentous procedures and meniscal surgery, the standard protocol included a limitation to partial weight bearing (20 kg) from the first postoperative day until 6 weeks postoperatively. Minimal weight bearing (5 kg) was indicated after OATS and no weight bearing was allowed after concomitant cartilage transplantation.
Follow-up
Patients were routinely followed up in ambulatory care at the authors’ institution at 6 weeks, 12 weeks and 1 year postoperatively and standard radiographs were obtained to evaluate consolidation of the osteotomy plane. In suspicion of a malunion or loss of correction, a computed tomography (CT) or hip–knee–ankle radiograph was conducted, respectively.
Medial cortical hinge fracture
The presence of a hinge fracture was assessed by two observers (M-C.R and M.J.F.) on each postoperative AP knee radiograph independently. A hinge fracture was defined as a disruption of the medial cortical bone. In cases of disagreement, a third observer (P.W.W.) was consulted to achieve consensus. Furthermore, the fracture morphology of all medial cortical hinge fractures was evaluated. A fracture in line with the osteotomy was classified as extension type fracture, while fracture lines diverting proximally or distally of osteotomy orientation were classified as proximal or distal type fractures, respectively.
Postoperative measurements and hinge position
Standard hip–knee–ankle radiographs acquired preoperatively and standard AP knee radiographs acquired on the first or second postoperative day were used for the analysis. Annotation was conducted by the main observer (M-C.R.) using the picture archiving and communication system (PACS). To assess inter- and intrarater reliability, measurements were performed two times at an interval of 1 month by the main observer (M-C.R.) and additionally by a second observer (P.W.W.) for 20 randomly selected patients.
Measurements were performed as previously described [53] and modified for the CW-technique: on the preoperative hip–knee–ankle radiographs, the preoperative osteotomy planning conducted via mediCAD® software (mediCAD Hectec GmbH, Altdorf, Germany) was identified and the wedge angle (angle α) and the height of the osteotomy wedge (interval “b”) were measured. In the postoperative standard AP radiographs, the length (interval “a”) and the inclination of the osteotomy (angle “ß”) were measured after identification of the osteotomy hinge and the anatomical axis of the femoral diaphysis. To calculate the effective, absolute correction (in mm), a persistent lateral cortical gap (interval “f”) was—if detected—measured and deducted from the preplanned correction. The location of the osteotomy hinge was quantified by measuring the horizontal distance between the medial cortical bone and the hinge (interval “c”) as well as the vertical (interval “d”) and horizontal (interval “e”) distances between the proximal margin of the adductor tubercle (AT) and the hinge point, the position was quantified. To quantify dislocation in case of a hinge fracture, the horizontal distance between the proximal and distal medial cortex was measured. The threshold for a significant dislocation was set at ≥ 2 mm, as previously described for HTO [30]. A comprehensive methodology of the measurements is presented in Fig. 1.
For consecutive analysis, the two-dimensional position of the osteotomy hinge was assigned to a corresponding sector in a sector grid as previously described for LOW-DFO [53]. Bony landmarks (AT, medial femoral cortical bone, femoral condyles) were used to define two columns (M, L) and three rows (I, II, III) of the grid. The sectors (IL, IIL, IIIL, IIM, and IIIM) were defined according to their location in the respective rows and columns. A detailed description of the five-sector grid is presented in Fig. 2. The allocation of the hinge position to the corresponding sector was performed by two observers (M-C.R. and P.W.W.) in agreement with each other.
The intraclass correlation values of quantitative measurements showed excellent intrarater (distance “a”, 0,963; distance “c”, 0,968; distance “d”, 0,932; distance “e”, 0,943; angle “ß”, 0,977) and good to excellent interrater reliability (distance „a “, 0,932; distance “c”, 0,919; distance “d”, 0,941; distance “e”, 0,914; angle “ß”, 0,857).
Risk factor analysis
Constitutional and technical risk factors predisposing for the incidence of consecutive complications after medial cortical fracture in LCW-DFO were analysed. The size of our study population statistically limited the number of risk factors to be evaluated, since repeatedly testing an excessive number of factors on a single dataset predisposes for the occurrence of Type 1 (false-positive) errors. Therefore, we selected the following preoperative factors a priori for assessment of our secondary hypothesis in this study: constitutional factors (BMI, age, sex, smoker), fracture morphology, quantitative hinge position measurements, concomitant procedures, postoperative dislocation, and implant type.
Statistical analysis
A total sample size of 76 subjects to detect a difference of 1.5 mm of a primary endpoint measurement, the absolute correction, at a calculated effect size of 0.66 to achieve a statistical power of 0.8 was determined in an a priori power analysis, performed with G*Power (Erdfelder, Faul, Buchner, Lang, HHU Düsseldorf, Düsseldorf, Germany) [10].
Statistical analysis was performed using SPSS software version 26.0 (IBM-SPSS, New York, USA). Continuous variables were reported as mean ± standard deviation. The distribution of continuous variables in the study collective was categorised via Shapiro–Wilk Test. Categorical variables were reported as count and percentages. According to their respective distribution, continuous variables were compared employing a parametric unpaired t test or the non-parametric Mann–Whitney U test. Categorical variables were compared performing the binary Fisher’s exact test or the Chi-square test, as statistically appropriate. The level of significance was set at p < 0.05.
To determine the risk of creating a medial cortical hinge fracture, a multivariable logistic regression was performed. The dependent variable was defined as the incidence of “medial cortical hinge fracture” (yes vs. no). Quantitative variables describing the location of the hinge position, that demonstrated a significant difference (p < 0.05) between the two groups (hinge fracture vs. no hinge fracture) in univariate analysis, were defined as independent variable and were used as the covariates.
Results
Incidence and fracture morphology
A medial cortical hinge fracture was detected in 38 (48%) of the cases. Assessing the fracture morphology, 26 (68%) of the fractures were classified as extension type fractures, while 8 (21%) were categorised as proximal and 4 (11%) as distal fractures (Fig. 3).
Risk factors for sustaining a hinge fracture
The association of technical and anatomical factors characterising the osteotomy cut and hinge position with the incidence of a hinge fracture is presented in Table 2.
For the osteotomy cut, an increased length of the osteotomy in mm (53.1 ± 10.9 vs. 57.7 ± 9.6; p = 0.049), an increased preplanned correction in mm (6.5 ± 1.9 vs. 7.9 ± 3; p = 0.040) as well as an increased absolute postoperative correction in mm (5 ± 2 vs. 7 ± 3; p = 0.015) were shown to be associated with the incidence of a medial cortical hinge fracture. Neither the angle of the excised wedge (α), nor the inclination of the osteotomy cut (ß), nor the distance of the hinge to the medial cortex (c) nor the craniocaudal position of the hinge (in relation to the AT) (d) nor the mediolateral distance of hinge to the AT (e) were shown to significantly influence the incidence of a medial cortical hinge fracture in our collective (p = n.s., respectively; for details, Table 2). The incidence of a medial cortical hinge fracture was significantly influenced by the horizontal location of the hinge in the sector grid—a higher incidence in column M compared to column L (p = 0.049) was detected—while neither the vertical location nor a specific two-dimensional sector were shown to exhibit a significant influence (p = n.s., respectively; for details, Table 2). A multivariable logistic regression model for the incidence of a “medial cortical hinge fracture” (model: p = 0.003) showed statistical significance for the absolute correction (p = 0.014). An increase of absolute correction by 1 mm increased the risk of creating a medial cortical hinge fracture by 32%.
Complications
Complications occurred in 7 (9%) of the cases. The incidence of malunions during follow-up was 6 (8%) across the entire patient collective. While not statistically significant (p = 0.10), these malunions tended to occur more frequently in the cases with a concomitant medial cortical hinge fracture (n = 5; 13%) compared to cases with an intact medial cortical bone (n = 1; 2%) (2). A detailed description of the associated complications in the study collective can be found in Table 3.
Furthermore, clinical, technical and anatomical risk factors for malunion after LCW-DFO were analysed in the subgroup of patients with a hinge fracture. It was shown that a mediolateral dislocation of the medial cortex of > 2 mm (Fig. 4) in the coronal plane on the postoperative standard AP radiograph predisposed for the incidence of malunion (p = 0.048; relative risk: 1.33; odds ratio: 13.31). A mediolateral dislocation of > 2 mm in the coronal plane could be detected in 100% of the cases with malunion. In our collective, demographic factors, smoker status, hinge location, fracture morphology and implant type did not significantly influence the rate of complications affecting osteotomy consolidation. A detailed risk factor analysis can be found in Table 4.
Discussion
The present study constitutes two main findings. First, the presence of a hinge fracture after LCW-DFO is common (48%) and three morphological types can be differentiated in the largest collective of LCW-DFOs in the literature to date. Furthermore, the secondary hypothesis could be confirmed, as the extent of surgical alignment correction and a hinge position close to the medial cortex predispose for medial cortical hinge fracture and a mediolateral dislocation of the medial cortex > 2 mm is significantly associated with malunion.
In the literature, lateral cortical hinge fractures have been identified as a common complication following MOW-HTO, occurring in 18–50% [7, 16, 22,23,24, 28, 30, 33, 34, 40, 49] and substantial evidence has been published identifying hinge fractures as an independent risk factors for inadequate bone healing [7, 16, 30]. While less extensively investigated to date, similar data have been published for hinge fractures following DFO, with an incidence of 39–46% reported for the LOW- [53], 48% for the MCW- [14] and 31% for the LCW-technique [36] in accordance with the incidence reported in the present study.
In MOW-HTO, a fracture classification established by Takeuchi et al. [49], that differentiates three morphological types (extension/proximal/distal), is well accepted [16, 33, 49]. Similarly, a classification has been published for LOW-DFO [53]. A study published by Nakayama et al. in LCW-DFO reports only two distinct fracture types (proximal / extension) in a study of 11 cases with a hinge fracture. In contrast, in the present study, three distinct fracture types (extension/proximal, distal) could be identified in accordance with the classifications established for HTO and LOW-DFO [49, 53], which may possibly be explained by a minimization of the risk for a type II error by a threefold greater power in the present study. In accordance with data reported after HTO [16, 23, 40, 49], LOW- [53] and LCW-DFO [36], an extension fracture was the most frequently identified morphological type.
As an accepted risk factor for malunion after MOW-HTO [7, 16, 30], substantial efforts have been made to mitigate the risk of unstable cortical hinge fracture in HTO [17, 33, 40], MCW-DFO [21] and LOW-DFO [53] by avoiding technical and constitutional risk factors.
In the present study, an increased height of the excised wedge as well as a hinge location close to the medial cortex have been identified as risk factors associated with a medial cortical hinge fracture. This is in accordance with data from HTO, that associated larger osteotomy gaps and location close to the opposite cortex with an increased risk for fracture [20, 24, 32, 33, 38, 47].
Interestingly, the wedge angle (A) was not found to significantly affect the risk for sustaining a hinge fracture, though trigonometrically related to wedge height (b). This seeming controversy may potentially be explained by the wedge angles inversely proportional relation the osteotomy length (a) and thus mediolateral position of the hinge—that, respectively, increase the risk for hinge fracture (p = 0.049)—and thus confounds the distribution of the wedge angles between the hinge fracture groups (“no” vs. “yes”). While the accuracy of the placement of the osteotomy cut in the sub-millimetre range is potentially unrealistic intraoperatively [50], the technical factors identified to reduce the risk of a hinge fracture may serve as an orientational guideline in planning the osteotomy (consideration of a double level approach in cases of excessive wedge height and avoidance of an overly lateral placement of the hinge) rather than absolute thresholds based on this retrospective study.
While a lower incidence of hinge fractures at the level or distal of the proximal margin of the AT was reported for LOW-DFO [53], no statistical significance for this finding could be constituted in the present study—possibly due the incidence of a type II error and a heterogeneity in the surgical technique due to the long inclusion period. The biomechanical properties of the lateral femoral condyle in response to an LCW osteotomy yet remain to be investigated.
While extensive investigations in HTO associated certain fracture configurations such as Takeuchi type II and III fractures with an instability of the osteotomy site [16, 33, 49], there is a paucity of evidence for DFO [39]. In accordance with the findings of the present study, studies investigating lateral DFO do not report the specific fracture morphology to be associated with an increased risk for instability [36, 53]. However, this study is the first to report an increased incidence of malunion in association with a mediolateral dislocation > 2 mm on the postoperative AP radiograph after lateral DFO. Accordingly, displaced cortical hinge fractures in HTO have been associated with an increased incidence of adverse events [28]. Hence, similar to HTO, a mediolateral dislocation may correspond to a clinically relevant instability at the osteotomy site [16, 31,32,33, 49]. For clarification, further studies in a larger collective correlating fracture morphology and cortical fracture location to a mediolateral dislocation are warranted. A loss of correction was shown in 5.3% in patients with a medial cortical fracture, a complication known after hinge fractures in high tibial osteotomy with an incidence between 1 and 15% [16, 28, 32, 33] and varising DFO of the valgus knee with an heterogenous incidence of 3–23% [8, 14, 25, 54].
We, therefore, recommend that a hinge fracture in LCW-DFO—if noticed intraoperatively—should be encountered by additional medial plate fixation, while—if recognised postoperatively—the weight bearing regime should be delayed to avoid complications [36], as commonly practiced in HTO [16, 23, 28, 38].
Limitations
While this study does demonstrate interesting findings, it is not without limitations. First, the incidence and configuration of medial cortical hinge fractures were assessed on standard postoperative AP radiographs, while previous studies postulated an even higher detection of this complication via CT [23]. As postoperative CT scans were not performed at the senior authors’ institution due to the increased radiation dose the patient is exposed to, we are aware that the incidence of medial cortical hinge fractures may be underreported. Second, radiological evaluation was conducted in the first 2 days postoperatively. Hence, the incidence of cortical disruptions beyond this time point could not be assessed. Third, as incidence of and risk factors for hinge fractures and complications were elected as primary and secondary endpoints, no clinical scores were included. Thus, the impact of this complication on the clinical outcome is not reported, as this exceeded the scope of the study. Fourth, certain p values fall just below the threshold of statistical significance, thus limiting the strength of the conclusion. Fifth, as the study inherits the associated biases of a retrospective design, further biomechanical and prospective clinical evidence may improve the understanding of technical risk factors for sustaining a hinge fracture after LCW-DFO.
Conclusion
In the largest collective of LCW-DFO to date, medial cortical hinge fractures are a common finding. An increased risk of sustaining a hinge fracture has to be expected with increasing osteotomy wedge height and a far medial location of the hinge. To minimise the risk of complications, dislocation after medial cortical disruption should be avoided since mediolateral dislocation greater 2 mm was associated with malunion. In these cases, additional medial plate fixation or a more restrictive rehabilitation protocol should be considered.
Abbreviations
- AT:
-
Adductor tubercle
- BMI:
-
Body-mass-index
- CT:
-
Computed tomography
- CW:
-
Closing wedge
- DFO:
-
Distal femoral osteotomy
- HTO:
-
High tibial osteotomy
- LCW:
-
Lateral closing wedge
- LOW:
-
Lateral open wedge
- MCW:
-
Medial closing wedge
- MLDFA:
-
Mechanical lateral distal femur angle
- MOW:
-
Medial open wedge
- OATS:
-
Osteochondral autograft transplant
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All listed authors have contributed substantially to this work: MCR, MJF, PF, and ABI engaged in the study conception and design; MCR, PL, PWW and MI performed the data collection; MCR and MJF performed the data analysis; MCR, MJF, PF and ABI performed the data interpretation; MCR, PML, PWW and MI drafted the manuscript and the figures, and performed the literature research; MCR, MJF, PML, PWW, MI, PF and ABI critically revised the manuscript.
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Andreas B. Imhoff is a consultant for Arthrosurface and Medi Bayreuth and receives royalties from Arthrex and Arthrosurface.
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Ethical approval was obtained from the Ethics Committee of the Technical University Munich (Nr.: 6/20 S). All the procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
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Research performed at the Department of Orthopedic Sports Medicine, Technical University of Munich, Munich, Germany.
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Rupp, MC., Winkler, P.W., Lutz, P.M. et al. Dislocated hinge fractures are associated with malunion after lateral closing wedge distal femoral osteotomy. Knee Surg Sports Traumatol Arthrosc 30, 982–992 (2022). https://doi.org/10.1007/s00167-021-06466-2
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DOI: https://doi.org/10.1007/s00167-021-06466-2