Abstract
Metalaxyl is broadly applied in agriculture to control peronosporales-caused diseases in plant. To investigate the toxic effects, zebrafish embryos were exposed to metalaxyl at 5, 50 and 500 ng/L for 72 h, the development of larvae were assessed. A significant decreased survival rate, body length, hatching rate (48 h post-fertilization), and a significant increased spinal curvature rate were observed in the 500 ng/L treatment. The lengths of lower jaw, upper jaw and hyomandibular were significantly decreased in the 5, 50 and 500 ng/L groups; while the lower jaw width was significantly increased in the 500 ng/L group. The lengths of palatoquadrate, ceratohyal and ethmoid plate were reduced. Though cyp26a1 mRNA levels showed no significant change, the transcription of bmp2b (in the 500 ng/L group), ihh (in the 50 and 500 ng/L groups), shh (in the 5, 50 and 500 ng/L groups) were significantly up-regulated, which may be related to the abnormal development of the skeleton.
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This work was supported by Natural Scientific Fund of Fujian Province, China (2019J01825), Fujian Provincial Department of Science and Technology.
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Wu, Y., Xu, Z., Xu, X. et al. Exposure to Metalaxyl Disturbs the Skeletal Development of Zebrafish Embryos. Bull Environ Contam Toxicol 104, 432–437 (2020). https://doi.org/10.1007/s00128-020-02806-z
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DOI: https://doi.org/10.1007/s00128-020-02806-z