Abstract
Objective
The study examined prevalence of self-reported use of medication recommended or prescribed by a doctor for depression, anxiety, stress, and sleep problems; and modelled baseline factors that predicted use over 3 years for each condition.
Methods
Analyses were undertaken on the 2001 and 2004 surveys of mid-aged women in the Australian Longitudinal Study on Women’s Health. Dependent variables were self-reported use in past 4 weeks of medications recommended or prescribed by a doctor for depression, anxiety, stress, or sleep problems in 2001 and 2004. Generalized Estimating Equations (GEE) were used to predict medication use for each condition over 3 years.
Results
Prevalence of prescribed medication use (2001, 2004) for each condition was depression (7.2, 8.9 %), anxiety (7.4, 9.0 %), stress (4.8, 5.7 %), and sleep problems (8.7, 9.5 %). Multivariable analyses revealed that odds of medication use across 3 years in all four conditions were higher for women with poorer mental and physical health, using hormone replacement therapy (HRT), or having seen a counsellor; and increased over time for depression, anxiety, and stress models. Medication use for depression was also higher for overweight/obese women, ex-smokers, and unmarried. Medication use for anxiety was higher for unmarried and non-working/low occupational women. Medication use for stress was higher for non-working women. Additional predictors of medication for sleep were surgical menopause, and area of residence.
Conclusions
Self-reported use of prescribed medication for four mental health conditions is increased over time after controlling for mental and physical health and other variables. Research needs to explore decision-making processes influencing differential rates of psychoactive medication use and their relationship with health outcomes.
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References
Begg S, Vos T, Barker B, Stevenson C, Stanley L, Lopez A (2007) The burden of disease and injury in Australia 2003. AIHW cat no. PHE 82. AIHW, Canberra
Slade T, Johnston A, Oakley Browne MA, Andrews G, Whiteford H (2009) 2007 National Survey of Mental Health and Wellbeing: methods and key findings. Aust N Z J Psychiatry 43(7):594–605
Britt H, Miller GC, Charles J, et al. (2011) General Practice Activity in Australia 2010–11: BEACH, Bettering the Evaluation And Care of Health. General practice series, no. 29. Sydney University Press, Sydney
Burgess PM, Pirkis JE, Slade TN, Johnston AK, Meadows GN, Gunn JM (2009) Service use for mental health problems: findings from the 2007 National Survey of Mental Health and Wellbeing. Aust N Z J Psychiatry 43:606–614
Department of Health and Ageing (2011) Australian statistics on medicines 2009. Commonwealth of Australia, Canberra
Atlantis E, Sullivan T, Sartorius N, Almeida OP (2012) Changes in the prevalence of psychological distress and use of antidepressants or anti-anxiety medications associated with comorbid chronic diseases in the adult Australian population, 2001–2008. Aust N Z J Psychiatry 46(5):445–456
Boyce P, Malhi G (2012) Supping with the devil? The dangers of liaisons between pharma and our profession. Aust N Z J Psychiatry 46:493–494
Partridge B, Lucke J, Hall W (2012) Public attitudes towards the acceptability of using drugs to treat depression and ADHD. Aust N Z J Psychiatry 46:958–965
Ilyas S, Moncrieff J (2012) Trends in prescriptions and costs of drugs for mental disorders in England, 1998–2010. Br J Psychiatry 200:393–398
Mojtabai R (2008) Increase in antidepressant medication in the US adult population between 1990 and 2003. Psychother Psychosom 77:83–92. doi:10.1159/000112885
Stephenson CP, Karanges E, McGregor IS (2013) Trends in the utilisation of psychotropic medications in Australia from 2000 to 2011. Aust N Z J Psychiatry 47:74–87. doi:10.1177/0004867412466595
Parikh SV, Lesage AD, Kennedy SH, Goering PN (1999) Depression in Ontario: under-treatment and factors related to antidepressant use. J Affect Disord 52:67–76
Harris MG, Burgess PM, Pirkis J, Siskind A, Slade T, Whiteford HA (2011) Correlates of antidepressant and anxiolytic, hypnotic or sedative medication use in an Australian community sample. Aust N Z J Psychiatry 45:249–260
Hollingworth SA, Burgess PM, Whiteford HA (2010) Affective and anxiety disorders: prevalence, treatment and antidepressant medication use. Aust N Z J Psychiatry 44:513–519. doi:10.3109/00048670903555138
Lader M (2011) Benzodiazepines revisited—will we ever learn? Addiction 106:2086–2109. doi:10.1111/j.1360-0443.2011.03563.x
Hollingworth SA, Siskind DJ (2010) Anxiolytic, hypnotic and sedative medication use in Australia. Pharmacoepidemiol Drug Saf 19:280–288. doi:10.1002/pds.1899
Goldney R, Bain M (2006) Prevalence of psychotropic use in a South Australian population. Aust Psychiatry 14:379–383
Page AN, Swannell S, Martin G, Hollingworth S, Hickie IB, Hall WD (2009) Sociodemographic correlates of antidepressant utilisation in Australia. Med J Aust 190:479–483
Kim J, Dennerstein L, Guthrie J (2006) Mental health treatments and associated factors amongst mid-aged Melbourne women. Archives Women’s Ment Health 9:15–22
Bramesfeld A, Grobe T, Schwartz F (2007) Who is treated, and how, for depression? An analysis of statutory health insurance data in Germany. Soc Psychiatry Psychiatr Epidemiol 42:740–746. doi:10.1007/s00127-007-0225-9
Chien I-C, Bih S-H, Lin C-H, Chou Y-J, Lee W-G, Lee C-H, Chou P (2011) Correlates and psychiatric disorders associated with psychotropic drug use in Taiwan. Soc Psychiatry Psychiatr Epidemiol 46:77–84. doi:10.1007/s00127-009-0169-3
Oksanen T, Vahtera J, Wesyerlund H, Pentti J, Sjösten N, Virtanen M, Kawachi I, Kivimäki M (2011) Is retirement beneficial for mental health? Antidepressant use before and after retirement. Epidemiology 22:553–559. doi:10.1097/EDE.0b013e31821c41bd
Weisberg RB, Dyck I, Culpepper L, Keller MB (2007) Psychiatric treatment in primary care patients with anxiety disorders: a comparison of care received from primary care providers and psychiatrists. Am J Psychiatry 164:276–282
Alonso J, Angermeyer MC, Bernert S et al (2004) Psychotropic drug utilization in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand 109(Suppl 420):55–64
Comeau J, Davies L (2012) Patterns of depressive symptoms and antidepressant use among women survivors of intimate partner violence. Soc Psychiatry Psychiatr Epidemiol 47:1527–1537. doi:10.1007/s00127-011-0459-4
Demyttenaere K, Bonnewyn A, Bruffaerts R, De Girolamo G, Gasquet I, Kovess V, Haro JM, Alonso J (2008) Clinical factors influencing the prescription of antidepressants and benzodiazepines: results from the European study of the epidemiology of mental disorders (ESEMeD). J Affect Disord 110:84–93. doi:10.1016/j.jad.2008.01.011
Tómasson K, Tómasson H, Zoёga T, Zigfússon E, Helgason T (2007) Epidemiology of psychotropic medication use: comparison of sales, prescriptions and survey data in Iceland. Nord J Psychiatry 61:471–478. doi:10.1080/08039480701773311
Parslow RA, Jorm AF (2001) Predictors of types of help provided to people using services for mental health problems: an analysis of the Australian National Survey of Mental Health and Wellbeing. Aust N Z J Psychiatry 35(2):183–189
Stein MB, Barrett-Connor E (2002) Quality of life in older adults receiving medications for anxiety, depression or insomnia: findings from a community-based study. Am J Geriatr Psychiatry 10:568–574
Voyer P, Cohen D, Lauzon S, Collin J (2004) Factors associated with psychotropic drug use among community-dwelling older persons: a review of empirical studies. BMC Nurs 3:3. doi:10.1186/1472-6955-3-3
Freeman EW, Sammel MD, Boorman DW, Zhang R (2014) Longitudinal pattern of depressive symptoms around natural menopause. JAMA Psychiatry 71(1):36–43. doi:10.1001/jamapsychiatry.2013.2819
Hardy R, Kuh D (2002) Change in psychological and vasomotor symptom reporting during the menopause. Soc Sci Med 55:1975–1988
Graziottin A, Serafini A (2009) Depression and the menopause: why antidepressants are not enough? Menopause 15(2):76–81. doi:10.1258/mi.2009.009021
Beck CA, Williams JVA, Wang JL, Kassam A, El-Guebaly N, Currie S et al (2005) Psychotropic medication use in Canada. Can J Psychiatry 50:605–613
Rutledge T, Linke S, Krantz D, Johnson B, Bittner V, Eastwood J, Eteiba W, Pepine C, Vaccarino V, Francis J, Vido D, Merz CNB (2009) Cormorbid depression and anxiety symptoms as predictors of cardiovasculat events: results from the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study. Psychosom Med 71:958–964
Patten SB, Esposito E, Carter B (2007) Reasons for antidepressant prescriptions in Canada. Pharmacoepidemiol Drug Saf 16:746–752
Brown W, Bryson L, Byles J, Dobson A, Lee C, Mishra G, Schofield M (1998) Women’s Health Australia: recruitment for a national longitudinal cohort study. Women Health 28:23–40
Young AF, Powers JR, Bell SL (2006) Attrition in longitudinal studies: who do you lose? Aust N Z J Public Health 30:353–361
Lee C, Dobson AJ, Brown WJ, Bryson L, Byles JE, Warner-Smith P, Young AF (2005) Cohort profile: the Australian Longitudinal Study on Women’s Health. Int J Epidemiol 34:987–991
Andresen EM, Malmgren JA, Carter WB, Patrick DL (1994) Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). Am J Prev Med 10:77–84
Ware JE, Kosinski M, Keller SD (1994) SF-36 SF-36 physical and mental health summary scales: a user’s manual. The Health Institute, New England Medical Center, Boston, MA
Mishra G, Schofield MJ (1998) Norms for the Physical and Mental Component Summary scores of the SF-36 for young, middle and older Australian women. Qual Life Res 7:215–220
Bell S, Lee C (2002) Development of the Perceived Stress Questionnaire for Young Women. Psychol Health Med 7(2):189–201
Bell S, Lee C (2003) Perceived stress revisited: the Women’s Health Australia project Young cohort. Psychol Health Med 8(3):343–353
Sherbourne CD, Stewart AL (1991) The MOS Social Support Survey. Soc Sci Med 32(6):705–714
Moser A, Stuck AE, Silliman RA, Ganz PA, Clough-Gorr KM (2012) The eight-item modified Medical Outcomes Study Social Support Survey: psychometric evaluation showed excellent performance. J Clin Epidemiol 65(10):1107–1116
Medical Outcomes Study Social Support Index (2002) University of Newcastle. http://www.alswh.org.au/for-researchers/data/data-dictionary-supplement. Accessed 4 June 2014
Zeger S, Liang K (1986) Longitudinal data analysis for discrete and continuous outcomes. Biometrics 42:121–130
Horton N, Bebchuk J, Jones C, Lipsitz S, Catalano P, Zahner G, Fitzmaurice G (1999) Goodness-of-fit for GEE: an example with mental health service utilization. Stat Med 18:213–222
Zhang J, Yu K (1998) What’s the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA 280:1690–1691
Parslow RA, Jorm AF (2004) Use of prescription medications and complementary and alternative medicines to treat depressive and anxiety symptoms: results from a community sample. J Affect Disord 82:77–84
Rauma PH, Koivumaa-Honkanen H, Kröger H, Tuppurainen MT, Kauhanen J, Honkanen RJ (2013) The relationship between self-reported and registry-based data on use of psychoactive medications in postmenopausal women. BMC Psychiatry 13:180. doi:10.1186/1471-244X-13-180
Pampallona S, Bollini P, Tibalidi G, Kupelnick B, Munizza C (2004) Combined pharmacotherapy and psychological treatment for depression. A systematic review. Arch Gen Psychiatry 61:714–719
Whiteford H, Doessel D, Sheridan J (2008) Uptake of Medicare Benefits Schedule items by psychologists and other mental health practitioners. Clin Psychol 12:50–56
Acknowledgments
The research on which this paper is based was conducted as part of the Australian Longitudinal Study on Women’s Health by The University of Newcastle and The University of Queensland. We are grateful to the women who provided the survey data. This study was funded by the Australian Department of Health and Ageing.
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The authors declare that there is no conflict of interest.
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Schofield, M.J., Khan, A. Predictors of prescribed medication use for depression, anxiety, stress, and sleep problems in mid-aged Australian women. Soc Psychiatry Psychiatr Epidemiol 49, 1835–1847 (2014). https://doi.org/10.1007/s00127-014-0896-y
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DOI: https://doi.org/10.1007/s00127-014-0896-y