Skip to main content

Advertisement

Log in

Multicenter evaluation of therapeutic strategies of inpatients with osteoporotic vertebral fractures in Germany

  • Original Article
  • Published:
European Journal of Trauma and Emergency Surgery Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to assess therapeutic strategies of inpatients with osteoporotic thoracolumbar fractures (OTF) in Germany.

Methods

Prospective multi-center study including 16 German-speaking trauma centers over a period of 7 months. All inpatients with OTF were included. Radiological and clinical data on admission and treatment modalities were assessed.

Results

Seven hundred and seven (99.3%) out of 712 included patients (73.3% female) could be evaluated. Mean age was 75 years (30–103). 51.3% could not remember any traumatic incident. Fracture distribution was from T2 to L5 with L1 (19%) most commonly affected. According to the Magerl classification type A1 (52.1%) and A3 (42.7%) were most common. B and C type injuries (2.6%) and neurological deficits (3.1%) were rare. Previous progression of vertebral deformation was evident in 34.4% of patients and related to t score below − 3 (Odds ratio 1.9661). Patients presented with anticoagulation medication (15.4%), dementia (13%), and ASA score > 3 (12.4%) frequently. 82.3% of patients complained of pain > 4 on VAS, 37% could not be mobilized despite pain medication according to grade II WHO pain ladder. 81.6% received operative treatment. Kyphoplasty (63.8%) and hybrid stabilization including kyphoplasty with (14.4%) or without screw augmentation (7.6%) were the techniques most frequently used. Invasiveness of treatment increased with degree of instability.

Conclusions

OTF are mostly type A compression fractures. Patients suffer from severe pain and immobilization frequently. Progression of deformity is correlated to t score below − 3. Treatment of inpatients is mainly surgical, with kyphoplasty followed by hybrid stabilization as commonly used techniques.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Hadji P, Klein S, Häussler B, et al. The bone evaluation study (BEST): patient care and persistence to treatment of osteoporosis in Germany. Int J Clin Pharmacol Ther. 2013;51:868–72.

    Article  Google Scholar 

  2. Svedbom A, Hernlund E, Ivergård M, et al. Osteoporosis in the European Union: a compendium of country-specific reports. Arch Osteoporos. 2013;8:137.

    Article  CAS  Google Scholar 

  3. Cooper C, Atkinson EJ, O’Fallon WM, Melton LJ. Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res. 1992;7:221–7.

    Article  CAS  Google Scholar 

  4. Suzuki N, Ogikubo O, Hansson T. The prognosis for pain, disability, activities of daily living and quality of life after an acute osteoporotic vertebral body fracture: its relation to fracture level, type of fracture and grade of fracture deformation. Eur Spine J. 2009;18:77–88.

    Article  Google Scholar 

  5. Cooper C, Atkinson EJ, Jacobsen SJ, et al. Population-based study of survival after osteoporotic fractures. Am J Epidemiol. 1993;137:1001–5.

    Article  CAS  Google Scholar 

  6. Rajasekaran S, Kanna RM, Schnake KJ, et al. Osteoporotic Thoracolumbar fractures—how are they different?—classification and treatment algorithm. J Orthop Trauma. 2017;31:S49–56.

    Article  Google Scholar 

  7. Neuerburg C, Mittlmeier L, Schmidmaier R, et al. Investigation and management of osteoporosis in aged trauma patients: a treatment algorithm adapted to the German guidelines for osteoporosis. J Orthop Surg Res. 2017;12:86.

    Article  Google Scholar 

  8. Chmielnicki M, Prokop A, Kandziora F, Pingel A. Surgical and non-surgical treatment of vertebral fractures in elderly. Z Orthop Unfall. 2019;157:654–67.

    Article  Google Scholar 

  9. Blattert TR, Schnake KJ, Gonschorek O, et al. Nonsurgical and surgical management of osteoporotic vertebral body fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU). Orthopade. 2019;48:84–91.

    Article  CAS  Google Scholar 

  10. Magerl F, Aebi M, Gertzbein SD, et al. A comprehensive classification of thoracic and lumbar injuries. Eur Spine J. 1994;3:184–201.

    Article  CAS  Google Scholar 

  11. Hadji P, Klein S, Gothe H, et al. The epidemiology of osteoporosis–Bone Evaluation Study (BEST): an analysis of routine health insurance data. Dtsch Arztebl Int. 2013;110:52–7.

    PubMed  PubMed Central  Google Scholar 

  12. Heini PF. The current treatment—a survey of osteoporotic fracture treatment. Osteoporotic spine fractures: the spine surgeon’s perspective. Osteoporos Int. 2005;16:S85-92.

    Article  Google Scholar 

  13. Vaccaro AR, Oner C, Kepler CK, et al. AOSpine thoracolumbar spine injury classification system: fracture description, neurological status and key modifiers. Spine (Phila Pa 1976). 2013;38:2028–37.

    Article  Google Scholar 

  14. Schnake KJ, Blattert TR, Hahn P, et al. Classification of osteoporotic Thoracolumbar spine fractures: recommendations of the spine Section of the German Society for Orthopaedics and Trauma (DGOU). Global Spine J. 2018;8:46S-49S.

    Article  Google Scholar 

  15. Shiu B, Le E, Jazini E, et al. Postoperative deep vein Thrombosis, pulmonary embolism, and myocardial infarction: complications after therapeutic anticoagulation in the patient with spine trauma. Spine (Phila Pa 1976). 2018;43:E766–72.

    Article  Google Scholar 

  16. Nazemi AK, Gowd AK, Carmouche JJ, et al. Prevention and management of postoperative delirium in elderly patients following elective spinal surgery. Clin Spine Surg. 2017;30:112–9.

    Article  Google Scholar 

  17. Kinder F, Giannoudis PV, Boddice T, Howard A. The effect of an abnormal BMI on orthopaedic trauma patients: a systematic review and meta-analysis. J Clin Med. 2020;9:E1302.

    Article  Google Scholar 

  18. Klein JD, Hey LA, Yu CS, et al. Perioperative nutrition and postoperative Complications in patients undergoing spinal surgery. Spine. 1996;21:2676–82.

    Article  CAS  Google Scholar 

  19. Hackett NJ, De Oliveira GS, Jain UK, Kim JYS. ASA class is a reliable independent predictor of medical complications and mortality following surgery. Int J Surg. 2015;18:184–90.

    Article  Google Scholar 

  20. Simcox T, Antoku D, Jain N, et al. Frailty syndrome and the use of frailty indices as a preoperative risk stratification tool in spine surgery: a review. Asian Spine J. 2019;13:861–73.

    Article  Google Scholar 

  21. Lim J, Choi SW, Youm JY, et al. Posttraumatic delayed vertebral collapse: Kummell’s disease. J Korean Neurosurg Soc. 2018;61:1–9.

    Article  Google Scholar 

  22. Lee HM, Park SY, Lee SH, et al. Comparative analysis of clinical outcomes in patients with osteoporotic vertebral compression fractures (OVCFs): conservative treatment versus balloon kyphoplasty. Spine J. 2012;12:998–1005.

    Article  Google Scholar 

  23. Zhang J, He X, Fan Y, et al. Risk factors for conservative treatment failure in acute osteoporotic vertebral compression fractures (OVCFs). Arch Osteoporos. 2019;14:24.

    Article  Google Scholar 

  24. Schuler M, Grießinger N. Opioids for noncancer pain in the elderly. Schmerz. 2015;29:380–401.

    Article  CAS  Google Scholar 

  25. Yuan WH, Hsu HC, Lai KL. Vertebroplasty and balloon Kyphoplasty versus conservative treatment for Osteoporotic vertebral compression fractures: a meta-analysis. Medicine (Baltimore). 2016;95:e4491.

    Article  Google Scholar 

  26. Wang B, Zhao CP, Song LX, Zhu L. Balloon kyphoplasty versus percutaneous vertebroplasty for osteoporotic vertebral compression fracture: a meta-analysis and systematic review. J Orthop Surg Res. 2018;13:264.

    Article  Google Scholar 

  27. Hartensuer R, Gehweiler D, Schulze M, et al. Biomechanical evaluation of combined short segment fixation and augmentation of incomplete Osteoporotic burst fractures. BMC Musculoskelet Disord. 2013;14:360.

    Article  Google Scholar 

  28. Spiegl UJ, Anemuller C, Jarvers JS, et al. Hybrid stabilization of unstable osteoporotic thoracolumbar vertebral body fractures: clinical and radiological outcome after a mean of 4 years. Eur Spine J. 2019;28:1130–7.

    Article  Google Scholar 

  29. Wittenberg R, Shea M, Swartz D, et al. Importance of bone mineral density in instrumented spine fusions. Spine (Phila Pa 1976). 1991;16:647–52.

    Article  CAS  Google Scholar 

  30. Galbusera F, Volkheimer D, Reitmaier S, et al. Pedicle screw loosening: a clinically relevant complication? Eur Spine J. 2015;24:1005–16.

    Article  Google Scholar 

  31. Kueny RA, Kolb JP, Lehmann W, et al. Influence of the screw augmentation technique and a diameter increase on pedicle screw fixation in the osteoporotic spine: pullout versus fatigue testing. Eur Spine J. 2014;23:2196–202.

    Article  Google Scholar 

  32. Mueller JU, Baldauf J, Marx S, et al. Cement leakage in pedicle screw augmentation: a prospective analysis of 98 patients and 474 augmented pedicle screws. J Neurosurg Spine. 2016;25:103–9.

    Article  Google Scholar 

  33. Spiegl UJ, Devitt BM, Kasivskiy I. Comparison of combined posterior and anterior spondylodesis versus hybrid stabilization in unstable burst fractures at the thoracolumbar spine in patients between 60 and 70 years of age. Arch Orthop Trauma Surg. 2018;138:1407–14.

    Article  Google Scholar 

  34. Vaccaro AR, Oner C, Kepler CK, et al. AOSpine thoracolumbar spine injury classification system: fracture description, neurological status and key modifiers. Spine (Phila Pa 1976). 2013;38(23):2028–37.

    Article  Google Scholar 

  35. Blattert TR, Schnake KJ, Gonschorek O, et al. Nonsurgical and surgical management of osteoporotic vertebral body fractures: recommendations of the spine section of the German Society for Orthopaedics and Trauma (DGOU). Global Spine J. 2018;8:50S-55S.

    Article  Google Scholar 

Download references

Acknowledgements

We would like to thank our colleagues Prof. Dr. Gholam Pajenda (Vienna) and Sarah Winkelkotte (Frankfurt) for their invaluable support for this study. Further, we thank the participating clinics for their contribution and efforts to realize this study.

Funding

No funds, grants, or other support were received.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Klaus John Schnake.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest to declare that are relevant to the content of this article.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schnake, K.J., Bouzakri, N., Hahn, P. et al. Multicenter evaluation of therapeutic strategies of inpatients with osteoporotic vertebral fractures in Germany. Eur J Trauma Emerg Surg 48, 1401–1408 (2022). https://doi.org/10.1007/s00068-021-01708-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00068-021-01708-x

Keywords

Navigation