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Selective local postoperative radiotherapy for T3–T4 N0 laryngeal cancer

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Abstract

Purpose

We aimed to investigate the appropriate postoperative radiotherapy dose and selective volume in T3–4 N0 laryngeal cancer patients treated with either total or partial laryngectomy.

Methods

Patients who received radiotherapy for locally advanced (T3–T4) and pathologic node-negative (N0) squamous cell laryngeal cancer were retrospectively evaluated. Radiotherapy was applied to median 60 Gy (range 54–60 Gy) as selective local radiotherapy (±stoma). The local treatment areas included postoperative bed + laryngeal area for patients with a partial laryngectomy, and the postoperative bed only for patients with total laryngectomy.

Results

The median follow-up time was 59 months and 52 patients were included. The 2‑year, 5‑year, and 8‑year locoregional recurrence controls (LRC) were 95.6%. The 2‑year and 5‑year OS rates were 93.8% and 78.9%, respectively. The 5‑year OS for age < 60 years was 95.8%, for above 60 years 56.5%.

Conclusion

Our data suggest that local selective irradiation to the postoperative bed + stoma is enough in patients with T3–4 N0 laryngeal cancer without applying elective nodal irradiation.

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Acknowledgements

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Funding

The authors received no specific funding for this work.

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Authors and Affiliations

  1. Department of Radiation Oncology, Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Cerrahpaşa Ave. Kocamustafapaşa St. No: 34/E Fatih, Istanbul, Turkey

    Meltem Dağdelen, Tuba Kurt Çatal, Halil Cumhur Yıldırım, Songül Çavdar Karaçam, Kimia Çepni & Ömer Erol Uzel

  2. Department of Radiation Oncology, Erzurum Regional Education and Research Hospital, Erzurum, Turkey

    Merve Şahin

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  1. Meltem Dağdelen
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  2. Merve Şahin
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Correspondence to Meltem Dağdelen.

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Conflict of interest

M. Dağdelen, M. Şahin, T.K. Çatal, H.C. Yıldırım, S.Ç. Karaçam, K. Çepni, and Ö.E. Uzel declare that they have no competing interests.

Ethical standards

For the purposes of our study, we performed a retrospective analysis with appropriate local ethics committee approval from 05.02.2021, numbered A‑01 (reference numbered: 24282).

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Dağdelen, M., Şahin, M., Çatal, T.K. et al. Selective local postoperative radiotherapy for T3–T4 N0 laryngeal cancer. Strahlenther Onkol 198, 1025–1031 (2022). https://doi.org/10.1007/s00066-022-01999-y

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