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Clinical Significance of Circumferential Aneurysmal Wall Enhancement in Symptomatic Patients with Unruptured Intracranial Aneurysms: a High-resolution MRI Study

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Abstract

Background and Purpose

The estimates on the risk of rupture of intracranial aneurysms remain a controversial topic. Circumferential aneurysmal wall enhancement (CAWE) on vessel wall magnetic resonance imaging (MRI) has been described in unstable aneurysms. Sentinel headaches and third nerve palsy are possible symptoms prior to the rupture of intracranial aneurysms. In this study, we aimed to demonstrate that CAWE could be associated with these symptoms.

Methods

We performed a retrospective analysis of consecutive symptomatic or asymptomatic patients with unruptured intracranial aneurysms who were examined by high-resolution MRI from October 2014 to November 2016. Two experienced neurovascular radiologists read the images independently and determined whether there was CAWE of the unruptured intracranial aneurysms. Then, we compared variable factors between patients with and without symptoms through univariate comparison and multivariable logistic regression analyses.

Results

A total of 45 unruptured intracranial aneurysms were detected in 37 patients. The agreement between 2 experienced readers for CAWE was good (kappa = 0.82; 95% confidence interval 0.66–0.99). CAWE of unruptured intracranial aneurysm was more frequently observed in symptomatic than in asymptomatic patients (16/23, 69.6% versus 6/22, 27.3%, respectively, P < 0.05). The CAWE was the only independent factor associated with symptoms in the multivariable logistic regression analysis (odds ratio 5.17; 95% confidence interval 1.30–20.52; P = 0.02).

Conclusions

Our study demonstrates that CAWE correlated with sentinel headaches and third nerve palsy caused by unruptured aneurysms, and this may be an additional clue to distinguish the cause of these symptoms.

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Authors and Affiliations

  1. Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, 450052, Zhengzhou, China

    Qichang Fu, Keyan Wang & Jingliang Cheng

  2. Department of Interventional Neuroradiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Sheng Guan & Chao Liu

Authors
  1. Qichang Fu
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  2. Sheng Guan
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  3. Chao Liu
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  4. Keyan Wang
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Correspondence to Jingliang Cheng.

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Conflict of interest

Q.C. Fu, S. Guan, C. Liu, K.Y. Wang and J.L. Cheng declare that they have no competing interests.

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Fu, Q., Guan, S., Liu, C. et al. Clinical Significance of Circumferential Aneurysmal Wall Enhancement in Symptomatic Patients with Unruptured Intracranial Aneurysms: a High-resolution MRI Study. Clin Neuroradiol 28, 509–514 (2018). https://doi.org/10.1007/s00062-017-0598-4

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  • DOI: https://doi.org/10.1007/s00062-017-0598-4

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