Skip to main content
SpringerLink
Log in

Relationship between inducible NOS single-nucleotide polymorphisms and hypertension in Han Chinese

Zusammenhang zwischen iNOS-Einzelnukleotidpolymorphismen und Hypertonie bei Han-Chinesen

  • Original articles
  • Published:
Herz Aims and scope Submit manuscript

Abstract

Background

Inducible nitric oxide synthase (iNOS) single-nucleotide polymorphisms have been reported to confer susceptibility to hypertension, but no consensus has been reached. The aim of this study was to investigate the association between iNOS and hypertension in a Chinese population.

Methods

This was a case-control study including 1172 hypertensive and 1172 control subjects to investigate the association between iNOS and hypertension.

Results

There were significant differences in the distribution of genotype and allele frequencies of rs2779249 and rs2297518 between hypertensive and normotensive subjects. Logistic regression analyses were performed with different genetic models (additive, dominant, recessive) adjusting for confounding risk covariates, including age, sex, body mass index, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, smoking, drinking, and family history of hypertension. The odds ratio (OR) was 1.27 (1.12, 1.44) in the additive model, 1.31 (1.09, 1.59) in the dominant, and 1.68 (1.28, 2.19) in the recessive model of rs2779249; the OR was 1.26 (1.06, 1.50) in the additive model and 1.46 (1.13, 1.89) in the dominant model of rs2297518.

Conclusion

The current study provides evidence that iNOS is strongly associated with hypertension.

Zusammenfassung

Hintergrund

Von Einzelnukleotidpolymorphismen der induzierbaren Stickstoffmonoxidsynthase (iNOS) wird berichtet, dass sie mit der Neigung zur Hypertonie einhergehen, darüber herrscht jedoch noch kein Konsens. Ziel der vorliegenden Studie war es, den Zusammenhang zwischen iNOS und Hypertonie in einer chinesischen Population zu untersuchen.

Methoden

Es handelt sich um eine Fall-Kontroll-Studie zur Untersuchung des Zusammenhangs zwischen iNOS und Hypertonie an 1172 Teilnehmern mit Hypertonie und 1172 Kontrollen.

Ergebnisse

Zwischen Teilnehmern mit Hypertonie und Kontrollen mit Normotonie bestanden signifikante Unterschiede in Bezug auf die Verteilung der Genotyp- und Allelhäufigkeiten von rs2779249 und rs2297518. Logistische Regressionsanalysen wurden mit verschiedenen genetischen Modellen (additiv, dominant, rezessiv) durchgeführt, unter Berücksichtigung von störenden Risikokovariaten wie Alter, Geschlecht, Body-Mass-Index, Gesamtcholesterin, Triglyzeride, High-Density-Lipoprotein-Cholesterin, Low-Density-Lipoprotein-Cholesterin, Rauchen, Alkohol und Hypertonie in der Familienanamnese. Die Odds Ratio (OR) betrug 1,27 (1,12; 1,44) im additiven Modell, 1,31 (1,09; 1,59) im dominanten und 1,68 (1,28; 2,19) im rezessiven Modell von rs2779249; die OR lag bei 1,26 (1,06; 1,50) im additiven Modell und bei 1,46 (1,13; 1,89) im dominanten Modell von rs2297518.

Schlussfolgerung

Die vorliegende Studie liefert Hinweise darauf, dass ein deutlicher Zusammenhang zwischen iNOS und Hypertonie besteht.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lewington S, Clarke R, Qizilbash N et al (2002) Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360(9349):1903–1913

    Article  PubMed  Google Scholar 

  2. Park BK (2010) Text book of preventive and social medicine; proceedings of the Banarsidas Publication, Jabalpur, 15th edn.

    Google Scholar 

  3. Kearney PM, Whelton M, Reynolds K et al (2005) Global burden of hypertension: analysis of worldwide data. Lancet 365(9455):217–223

    Article  PubMed  Google Scholar 

  4. Huan T, Esko T, Peters MJ et al (2015) A meta-analysis of gene expression signatures of blood pressure and hypertension. PLOS Genet 11(3):e1005035

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Rafiq S, Anand S, Roberts R (2010) Genome-wide association studies of hypertension: have they been fruitful? J Cardiovasc Transl Res 3(3):189–196

    Article  PubMed  Google Scholar 

  6. Moncada S, Higgs A (1993) The L‑arginine-nitric oxide pathway. N Engl J Med 329(27):2002–2012

    Article  PubMed  CAS  Google Scholar 

  7. Mayer B, Hemmens B (1997) Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 22(12):477–481

    Article  PubMed  CAS  Google Scholar 

  8. Umar S, Laarse AVD (2010) Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem 333(1):191–201

    Article  PubMed  CAS  Google Scholar 

  9. Pauletto P (2006) Inflammation and hypertension: the search for a link. Nephrol Dial Transplant 21(4):850–853

    Article  PubMed  Google Scholar 

  10. Kuhl SJ, Rosen H (1998) Nitric oxide and septic shock. From bench to bedside. West J Med 168(3):176

    PubMed  PubMed Central  CAS  Google Scholar 

  11. Rutherford S, Johnson MP, Curtain RP et al (2001) Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension. Hum Genet 109(4):408–415

    Article  PubMed  CAS  Google Scholar 

  12. Kumar U, Chen J, Sapoznikhov V et al (2005) Overexpression of inducible nitric oxide synthase in the kidney of the spontaneously hypertensive rat. Clin Exp Hypertens 27(1):17–31

    Article  PubMed  CAS  Google Scholar 

  13. Rodriguez-Iturbe B, Zhan CD, Quiroz Y et al (2003) Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats. Hypertension 41(2):341–346

    Article  PubMed  CAS  Google Scholar 

  14. Castro MM, Rizzi E, Rodrigues GJ et al (2009) Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension. Free Radic Biol Med 46(9):1298–1307

    Article  PubMed  CAS  Google Scholar 

  15. Hallemeesch MM, Janssen BJ, De Jonge WJ et al (2003) NO production by cNOS and iNOS reflects blood pressure changes in LPS-challenged mice. Am J Physiol Endocrinol Metab 285(4):E871–E875

    Article  PubMed  CAS  Google Scholar 

  16. Wang SS, Davis S, Cerhan JR et al (2006) Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Carcinogenesis 27(9):1828–1834

    Article  PubMed  CAS  Google Scholar 

  17. Smith CJ, Santhanam L, Bruning RS et al (2011) Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans. Hypertension 58(5):935–942

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Escames G, Khaldy H, Leon J et al (2004) Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine. J Hypertens 22(3):629–635

    Article  PubMed  CAS  Google Scholar 

  19. Nikkari ST, Maatta KM, Kunnas TA (2015) Functional inducible nitric oxide synthase gene variants associate with hypertension: a case-control study in a Finnish population – the Tamrisk study. Medicine (Baltimore) 94(46):e1958

    Article  PubMed Central  CAS  Google Scholar 

  20. Stoclet JC, Muller B, Gyorgy K et al (1999) The inducible nitric oxide synthase in vascular and cardiac tissue. Eur J Pharmacol 375(1–3):139–155

    Article  PubMed  CAS  Google Scholar 

  21. Hayakawa H, Raij L (1998) Nitric oxide synthase activity and renal injury in genetic hypertension. Hypertension 31(1 Pt 2):266–270

    Article  PubMed  CAS  Google Scholar 

  22. Hong HJ, Loh SH, Yen MH (2000) Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase. Br J Pharmacol 131(3):631–637

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  23. Amrani-Midoun A, Kiando SR, Treard C et al (2016) The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of Oran city. Int J Cardiol 225:408–411

    Article  PubMed  Google Scholar 

  24. Zhang X, Zhao H, Zhang J et al (2015) Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han population. Biomed Mater Eng 26(Suppl 1):S1977–S1983

    PubMed  Google Scholar 

  25. Zhong S, Xu J, Li W et al (2013) Methionine synthase A2756G polymorphism and breast cancer risk: an up-to-date meta-analysis. Gene 527(2):510–515

    Article  PubMed  CAS  Google Scholar 

Download references

Funding

This study was funded by The Science and Technology Support Projects of Xinjiang Production and Construction Corps (No.: 2012AB014)

Author information

Authors and Affiliations

  1. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China

    Z. Zhai & D. Wang

  2. Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, 832000, Shihezi, Xinjiang, China

    Z. Zhai, Z. Wang, L. Wang, S. Chen & H. Ren

Authors
  1. Z. Zhai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Z. Wang.

Ethics declarations

Conflict of interest

Z. Zhai, Z. Wang, L. Wang, S. Chen, H. Ren, and D. Wang declare that they have no competing interests.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhai, Z., Wang, Z., Wang, L. et al. Relationship between inducible NOS single-nucleotide polymorphisms and hypertension in Han Chinese. Herz 43, 461–465 (2018). https://doi.org/10.1007/s00059-017-4591-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00059-017-4591-0

Keywords

Schlüsselwörter

Search

Navigation