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4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity

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Abstract

Three new 4-phenylcoumarins, mesuaferlinns A–C (1–3), together with ten other known 4-phenylcoumarins, 4–13, were isolated from the branches and leaves of Mesua ferrea Linn. (Clusiaceae). The structure of compounds 1–3 were determined on the basis of spectroscopic methods including extensive analysis of NMR and mass spectroscopic data. Ten 4-phenylcoumarins were tested for their cytochrome P450 family 1 enzymes (CYP1A1, CYP1A2, and CYP1B1) inhibitory effects. Compounds 5 and 10 were found to be the most potent two CYP1B1 inhibitors with inhibitory viabilities values of 56.64% and 47.46%, respectively.

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Author notes

  1. These authors contributed equally: Fengxu Zhou, Ruoyue Huang

Authors and Affiliations

  1. School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming, Yunnan, 650000, China

    Fengxu Zhou, Tingting Cao, Jia Liu, Weimin Yang & Xian Li

  2. Shunde Institute for Drug Control, Foshan, Guangdong, 528000, China

    Fengxu Zhou

  3. West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China

    Ruoyue Huang & Fei Li

Authors
  1. Fengxu Zhou
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  3. Tingting Cao
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  4. Jia Liu
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  5. Weimin Yang
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  7. Xian Li
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Contributions

Fengxu Zhou performed the experiments, including isolation, structure identification, and prepared the manuscript. Ruoyue Huang has contributed to the study of active compounds, molecular docking and the writing of active parts. Tingting Cao and Jia Liu performed the auxiliary experiments. Weimin Yang guided the experiments. Fei Li and Xian Li were the supervisor of the present work, checked the structure determination of the isolated compounds and the biological study, and completed the redaction of the article.

Funding

This study was funded by the Yunnan Provincial Science and Technology Department (NoS. 2019HB025, 202005AE160004, 202005AF150043, 202201AY070001-004) and the National Natural Science Foundation of China (31860087).

Corresponding authors

Correspondence to Weimin Yang, Fei Li or Xian Li.

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Zhou, F., Huang, R., Cao, T. et al. 4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity. Med Chem Res 31, 2172–2181 (2022). https://doi.org/10.1007/s00044-022-02962-3

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  • DOI: https://doi.org/10.1007/s00044-022-02962-3

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