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N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products

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Abstract

Synthetic approaches to daunorubicin derivatives containing azide and propargyl fragments were developed. A series of phosphonate and bisphosphonate derivatives (including those containing P–C–P fragments) were obtained by the methods of click chemistry and by direct amidation. The obtained compounds show small cytotoxicity not higher than that of parent daunorubicin.

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Acknowledgements

This work was supported by the Ministry of Science and Higher Education of the Russian Federation.

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Authors and Affiliations

  1. A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS), Moscow, 119991, Russia

    Aleksandra A. Moiseeva, Oleg I. Artyushin, Lada V. Anikina, Zinaida S. Klemenkova & Valery K. Brel

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  1. Aleksandra A. Moiseeva
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  2. Oleg I. Artyushin
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  3. Lada V. Anikina
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  4. Zinaida S. Klemenkova
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Correspondence to Valery K. Brel.

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Moiseeva, A.A., Artyushin, O.I., Anikina, L.V. et al. N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products. Med Chem Res 31, 1011–1025 (2022). https://doi.org/10.1007/s00044-022-02889-9

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