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Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines

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Abstract

A novel series of amide functionalized imidazo[1,2-a]pyridine (14a–14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14j showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC50 values of 0.021 ± 0.0012 µM, 0.95 ± 0.039 µM, 0.091 ± 0.0053 µM, and 0.24 ± 0.032 µM, respectively.

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Authors and Affiliations

  1. Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001, India

    Chekuri Sharmila Rani & Mandava Venkata Basaveswara Rao

  2. Department of Pharmacy, SANA College of Pharmacy, Kodad, Telangana, 508206, India

    Alugubelli Gopi Reddy

  3. Department of Pharmacy, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India

    E. Susithra

  4. Pharmaceutical Chemistry Department, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia

    Kit-Kay Mak & Mallikarjuna Rao Pichika

  5. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India

    Sreenivasulu Reddymasu

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  1. Chekuri Sharmila Rani
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Rani, C.S., Reddy, A.G., Susithra, E. et al. Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines. Med Chem Res 30, 74–83 (2021). https://doi.org/10.1007/s00044-020-02638-w

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