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Antioxidant and anticholinesterase activities of Ferulago syriaca Boiss. and F. isaurica Peșmen growing in Turkey

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Abstract

Ferulago species have been utilized since ancient times as anthelmintic, digestive, sedative, and aphrodisiac, along with salads or as seasoning in view of their special odors. The study reports the antioxidant and anticholinesterase activities of extracts, fractions from roots, and aerial parts together with isolated compounds from chloroform fractions of roots [isoimperatorin (1), bergapten (2), prantschimgin (3), xanthotoxin (4), and felamidin (5)] from Ferulago syriaca Boiss. and F. isaurica Peșmen. The phenolic contents and antioxidant activities of extracts, fractions, and isolated compounds were performed with Folin–Ciocalteu’s phenol indicator, qualitative and quantitative Diphenyl-1-picrylhydrazyl (DPPH), and TBA methods. In addition, anticholinesterase activity was carried out via Ellman’s method. The highest total phenolic content was found in the EtOAc fraction from the root of F. syriaca (1156.01 ± 4.92 mg/g), on the other hand, the lowest total phenolic content was shown in the hexane fraction from the root of F. isaurica (12.45 ± 4.45 mg/g). All samples showed antioxidant activity with DPPH test and the highest activities were observed in CHCl3 fractions of roots from F. syriaca and F. isaurica (9.99 and 8.78 μg/mL, respectively). The CHCl3 fraction of root from F. isaurica was found to have strong inhibition against AChE (46.99%) and BuChE (88.56 ± 2.34%) at 20 µg/mL. Prantschimgin (74.82%) and felamidin (77.11%) demonstrated strong inhibition toward BuChE. CHCl3 fractions of roots from these species had notable antioxidant and anticholinesterase activities. It displayed inhibitory activities on AChE and BuChE, and moreover considerable antioxidant activity.

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References

  • Basile A, Sorbo S, Spadaro V (2009) Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae). Molecules 14:939–952

    Article  PubMed  CAS  Google Scholar 

  • Blois MS (1958) Antioxidant determinations by the use of a stable free radical. Nature 26:1199–1200

    Article  Google Scholar 

  • Brand WW, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. LWT Food Sci Technol 28:25–30

    Article  Google Scholar 

  • Bulut G, Tuzlacı E, Doğan A, Şenkardeş İ (2014) An ethnopharmacological review on the Turkish Apiaceae species. Istanbul J Pharm 44:163–179

    Google Scholar 

  • Celik A, Arslan I, Herken EN, Ermis A (2013) Constituents, oxidant-antioxidant profile, and antimicrobial capacity of the essential oil obtained from Ferulago sandrasica Peşmen and Quézel. J Int J Food Prop 16:1655–1662

    Article  CAS  Google Scholar 

  • Demirci S, Özkan EE (2014) Ethnobotanical studies of some Apiaceae plants in Kahramanmaras and a review of their phytochemical studies. Istanb J Pharm 44:241–250

    Google Scholar 

  • Dickson DW (1997) Neuropathological diagnosis of Alzheimer’s disease: a perspective from longitudinal clinicopathological studies. Neurobiol Aging 18:21–26

    Article  Google Scholar 

  • Dinis TCP, Madeira VMC, Almeida LM (1994) Action of phenolic derivates (acetoaminophen, salycilate, and 5-aminosalycilate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch Biochem Biophys 315:161–169

    Article  PubMed  CAS  Google Scholar 

  • Ellman GL, Courtney D, Andies V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95

    Article  PubMed  CAS  Google Scholar 

  • Erdurak CS (2003) Investigations on Ferulago isaurica Peşmen and F. syriaca Boiss. (Umbelliferae) species. Ankara University Doctorate Thesis, Ankara

  • Ferreira A, Proenc C, Serralheiro MLM, Araujo MEM (2006) The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. J Ethnopharmacol 108:31–37

    Article  PubMed  CAS  Google Scholar 

  • Gauthier S, Wirth Y, Möbius HJ (2005) Effects of memantine on behavioural symptoms in Alzheimer’s disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies. Int J Geriatr Psychiatry 20(5):459–464

    Article  PubMed  CAS  Google Scholar 

  • Gibson GE, Huang HM (2005) Oxidative stress in Alzheimer’s disease. Neurobiol Aging 26:575–578

    Article  PubMed  CAS  Google Scholar 

  • Golfakhrabadi F, Khanavi M, Ostad SN, Saeidnia S, Vatandoost H, Abai MR, Hafizi M, Yousefbeyk F, Rad YR, Baghenegadian A, Ardekani MRS (2015) Biological activities and composition of Ferulago carduchorum. Essent Oil J Arthropod-Borne Dis 9(1):104–115

    Google Scholar 

  • Mavi A, Terzi Z, Ozgen U, Yildirim A, Coşkun M (2004) Antioxidant properties of some medicinal plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae). Biol Pharm Bull 27:702–705

    Article  PubMed  CAS  Google Scholar 

  • Mileski KS, Džamić AM, Ćirić AD, Ristić MS, Grujić SM, Matevski VS, Marin PD (2015) Composition, antimicrobial and antioxidant properties of endemic species Ferulago macedonica Micevski & E. Mayer. Rec Nat Prod 9(2):208–223

    Google Scholar 

  • Naseri M, Monsef-Esfehani HR, Saeidnia S, Dastan D, Gohari AR (2013) Antioxidative coumarins from the roots of Ferulago subvelutina. Asian J Chem 25(4):1875–1878

    CAS  Google Scholar 

  • Pesmen H (1972) Ferulago W. Koch. In: Davis PH (ed) Flora of Turkey and the East Aegean Islands. Edinburgh University Press, Edinburgh, 4:469–471

    Google Scholar 

  • Piao XL, Park IH, Baek SH, Kim HY, Park MK, Park JH (2004) Antioxidative activity of furanocoumarins isolated from Angelicae dahuricae. J Ethnopharmacol 93:243–246

    Article  PubMed  CAS  Google Scholar 

  • Rafieian-kopaei M, Shahinfard N, Rouhi-Boroujeni H, Gharipour M, Darvishzadeh-Boroujeni P (2014) Effects of Ferulago angulata extract on serum lipids and lipid peroxidation. J Evid Based Complement Altern Med 2014:1–4

    Article  Google Scholar 

  • Sajjadi SE, Shokoohinia Y, Jamali M (2012) Chemical composition of essential oil of Ferulago macrocarpa (Fenzl) Boiss. fruits. Res Pharm Sci 7(3):197–200

    PubMed  PubMed Central  CAS  Google Scholar 

  • Saya O (2012) Ferulago W. Koch. In: Güner A, Aslan S, Ekim T, Vural M, Babaç MT (eds) Türkiye Bitkileri Listesi (Damarlı Bitkiler). Nezahat Gökyiğit Botanic Garden Publications, İstanbul, pp 62–64

    Google Scholar 

  • Senol FS, Woz´niak KSk, Khan MTH, Orhan IE, Sener B, Głowniak K (2011) An in vitro and in silico approach to cholinesterase inhibitory and antioxidant effects of the methanol extract, furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits. Phytochem Lett 4:462–467

    Article  CAS  Google Scholar 

  • Shahbazia Y, Shavisi N (2015) Chemical composition, antioxidant and antimicrobial activities of the essential oil and methanolic extract of Ferulago bernardii Tomk. & M. Pimen of Iran. Arch Phytopathol Plant Prot 48:699–710

    Article  CAS  Google Scholar 

  • Singleton VL, Rossi JA (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Viticult 16:144–158

    CAS  Google Scholar 

  • Slinkard K, Singleton VL (1977) Total phenols analysis: automation and comparison with manual methods. Am J Enol Viticult 28:49–55

    CAS  Google Scholar 

  • Souri E, Farsam H, Sarkheil P, Ebadi F (2004) Antioxidant activity of some Furanocoumarins isolated from Heracleum persicum. Pharm Biol 42(6):396–399

    Article  CAS  Google Scholar 

  • Takao T, Kitatani F, Watanebe N, Yagi A, Sakata K (1994) A simple screening method for antioxidants and isolation of several antioxidants produced by marine-bacteria fromfish and shellfish. Biosci Biotechnol Biochem 58:1780–1783

    Article  CAS  Google Scholar 

  • Tavakoli S, Vatandoost H, Zeidabadinezhad R, Hajiaghaee R, Hadjiakhoondi A, Abai MR, Yassa N (2017) Gas chromatography, GC/mass analysis and bioactivity of essential oil from aerial parts of Ferulago trifida: antimicrobial, antioxidant, AChE inhibitory, general toxicity, MTT assay and larvicidal activities. J Arthropod-Borne Dis 11(3):414–426

    PubMed  PubMed Central  Google Scholar 

  • Tavakolia S, Yassab N, Delnavazib MR, Akhbaric M, Hadjiakhoondib A, Hajimehdipoore H, Khalighi-Sigaroodia F, Hajiaghaeea R (2017) Chemical composition and biological activities of the essential oils from different parts of Ferulago trifida Boiss. J Essent Oil Res 29(5):407–419

    Article  CAS  Google Scholar 

  • Yerdelen KÖ,Tosun E (2015) Synthesis, docking and biological evaluation of oxamide and fumaramide analogs as potential AChE and BuChE inhibitors. Med Chem Res 24:588–602

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank Prof. Dr. Hayri Duman for his worthwhile support for diagnosing of plant material.

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Authors and Affiliations

  1. Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey

    Songul Karakaya

  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey

    Mehmet Koca

  3. Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Ankara, Turkey

    Ceyda Sibel Kılıc & Maksut Coskun

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  1. Songul Karakaya
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  2. Mehmet Koca
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  3. Ceyda Sibel Kılıc
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  4. Maksut Coskun
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Correspondence to Songul Karakaya.

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Karakaya, S., Koca, M., Kılıc, C.S. et al. Antioxidant and anticholinesterase activities of Ferulago syriaca Boiss. and F. isaurica Peșmen growing in Turkey. Med Chem Res 27, 1843–1850 (2018). https://doi.org/10.1007/s00044-018-2196-7

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