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In vitro and in silico evaluation of 2-(substituted phenyl) oxazolo[4,5-b]pyridine derivatives as potential antibacterial agents

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Abstract

Increasing resistance to antibiotics is a major problem worldwide and stimulates the development of new bacterial inhibitors. Series of oxazolo[4,5-b]pyridine synthesized in our lab was examined to screen them as potential antimicrobial agents. The antimicrobial analyses of the synthesized compound were based on minimum inhibitory concentration determination, against four strains of bacteria. The results showed that the synthesized compounds have elicited good activity profile against methicillin-resistant Staphylococcus aureus (S. aureus), the bacterium that is largely responsible for hospital-acquired infections. Moreover, synthesized compounds were also docked against enterotoxin protein of S. aureus which belongs to Staphylococcal enterotoxin type A(SEA). In vitro and in silico studies revealed that compounds 3d, 3g, and 3h have demonstrated significant antibacterial activity in comparison to the standard control drug ampicillin and streptomycin.

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Acknowledgements

This work is supported by the financial assistance received from UGC-SAP-DRS-I [No. F. 540/13/DRS-I/2016(SAP-I)] and G.K.R is thankful to UGC-MANF (F1-17.1/2017-18/MANF-2017-18-MAD-73866 /(SA-III/Website)) for Junior Research Fellowship. The authors are thankful to Sophisticated Analytical Instrumentation Facility Punjab University, Chandigarh, for providing experimental results.

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  1. School of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Indore, MP, 452 001, India

    Gagandeep Kour Reen, Ashok Kumar & Pratibha Sharma

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  1. Gagandeep Kour Reen
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  2. Ashok Kumar
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  3. Pratibha Sharma
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Correspondence to Pratibha Sharma.

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Reen, G.K., Kumar, A. & Sharma, P. In vitro and in silico evaluation of 2-(substituted phenyl) oxazolo[4,5-b]pyridine derivatives as potential antibacterial agents. Med Chem Res 26, 3336–3344 (2017). https://doi.org/10.1007/s00044-017-2026-3

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  • DOI: https://doi.org/10.1007/s00044-017-2026-3

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