Abstract
Quinoxaline derivatized with coumarin viz., 3a–f and with sydnones viz., 7a–0 were synthesized using pyridine as catalyst. Among the coumarin derivatives, 3a and 3b have been screened for anticancer activity against 60 human cancer cell lines at NIH (USA). Compound 3a has shown 55.75 % GI against Melanoma (MALME-M) tumor cell line. Further, the sydnone derivatives 7d–i inhibited the Mycobacterium tuberculae H37RV.
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Acknowledgments
The authors acknowledge the NCI, NIH, Bethesda, USA for selecting samples for in vitro anticancer analyses under DTP. The authors are grateful to NGH College of Dental sciences, Belgaum, Karnataka, India for anti-tubercular activity. The authors wish to thank the University Scientific Instrumentation Centre (USIC), Karnataka University, Dharwad, NMR Research Centre, Indian Institute of Science (IISc), Bengaluru, India for carrying out the spectral analyses. The authors (AAK and RRK) are also thankful to UGC, New Delhi for providing financial assistant under UGC-UPE thrust area “Antitumor activity: An Integrated Approach”. Vide F. No. 14-3/2012 (NS/PE).
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Kamble, A.A., Kamble, R.R., Kumbar, M.N. et al. Pyridine-catalyzed synthesis of quinoxalines as anticancer and anti-tubercular agents. Med Chem Res 25, 1163–1174 (2016). https://doi.org/10.1007/s00044-016-1558-2
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DOI: https://doi.org/10.1007/s00044-016-1558-2