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α-Glucosidase inhibitor compounds from Aspergillus terreus RCC1 and their antioxidant activity

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Abstract

As part of the search for naturally derived α-glucosidase inhibitors, the chemical components isolated from Aspergillus terreus RCC1 were evaluated. Three butenolides compounds were isolated and their structures were identified as isoaspulvinone E (1), aspulvinone E (2), and butyrolactone I (3). Compounds 1 and 2 exhibited high activity on α-glucosidase inhibitory with IC50 values of 8.92 and 2.70 μM, respectively, lower than quercetin (IC50 = 10.92 μM). However, these compounds exhibited moderate antioxidant activity with IC50 values of 167.82 and 114.86 μM, respectively. To the best of our knowledge, this is the first report of both the α-glucosidase inhibitory and antioxidant activities of aspulvinone compounds. In particular, both the aspulvinone compounds could be employed as a lead compound for a new potential antidiabetic derived from terrestrial fungi.

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Acknowledgments

The authors are deeply thankful to Dr. Shigeki Mori of the Integrated Center for Sciences, Ehime University for obtaining the data of X-ray crystallography, and Prof. Dr Satoshi Yamauchi and Tuti Wukirsari M. Agr of Faculty of Agriculture, Ehime University for measurement of optical rotation. We also thank to Nina Artanti MSc for helping this manuscript preparation and valuable discussion.

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Authors and Affiliations

  1. Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Banten, 15314, Indonesia

    Rizna Triana Dewi, Sofa Fajriah & Muhammad Hanafi

  2. Department of Applied Biosciences, Faculty of Agriculture, Ehime University, 3-5-7 Tarumi Matsuyama, Matsuyama, Ehime, 790-8566, Japan

    Sanro Tachibana

  3. Faculty of Pharmacy, Pancasila University, Srengseng Sawah, Jagakarsa, Jakarta, 12640, Indonesia

    Muhammad Hanafi

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  1. Rizna Triana Dewi
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  2. Sanro Tachibana
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  4. Muhammad Hanafi
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Correspondence to Rizna Triana Dewi.

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Dewi, R.T., Tachibana, S., Fajriah, S. et al. α-Glucosidase inhibitor compounds from Aspergillus terreus RCC1 and their antioxidant activity. Med Chem Res 24, 737–743 (2015). https://doi.org/10.1007/s00044-014-1164-0

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  • DOI: https://doi.org/10.1007/s00044-014-1164-0

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