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Synthesis and cytotoxic activities of novel bergenin derivatives

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Abstract

A series of novel bergenin derivatives based on alcoholic hydroxyl group(s) modifications have been designed, synthesized and their cytotoxic activities against two human cancer cell lines including K562 and HL60 were evaluated. Over half of the tested derivatives, mainly with nitrogen containing moieties, displayed strong activities against K562 and HL60 cell lines.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China (Grant No. 20562012, 21162033).

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Authors and Affiliations

  1. Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People’s Republic of China

    Na-Na Liu, Jing-Bo Chen, Xiang-Hui Zeng & Jian-Ping Liu

  2. Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, 650031, People’s Republic of China

    Fu-Kai Bao & Shui-Jing Chi

Authors
  1. Na-Na Liu
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  2. Fu-Kai Bao
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  3. Jing-Bo Chen
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  4. Xiang-Hui Zeng
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  5. Shui-Jing Chi
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  6. Jian-Ping Liu
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Corresponding author

Correspondence to Jian-Ping Liu.

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Na–Na Liu and Fu-Kai Bao have contributed equally to this paper.

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Liu, NN., Bao, FK., Chen, JB. et al. Synthesis and cytotoxic activities of novel bergenin derivatives. Med Chem Res 23, 4803–4813 (2014). https://doi.org/10.1007/s00044-014-1050-9

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  • DOI: https://doi.org/10.1007/s00044-014-1050-9

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