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Zeaoxazolinone, a new antifungal agent from Zea mays roots

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Abstract

A new 7-methoxy-2-benzoxazolinone dimer named zeaoxazolinone (2), together with four known compounds; 9-Z-hexadecenoic acid (1), 6-methoxy-benzoxazolinone (3), gallic acid (4), and β-sitosterol-3-O-β-d-glucopyranoside (5) were isolated from Zea mays L. roots. The structural elucidation of isolated metabolites was established on the basis of UV, IR, 1D, 2D NMR, and MS spectral analyses. Compound 2 exhibited a potent antifungal activity against Aspergillus flavus, Fusarium oxysporum, and Candida albicans.

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Acknowledgments

The authors are grateful to the ‘Research Center of the Female Scientific and Medical Colleges’, Deanship of Scientific Research, King Saud University for the financial support and to Dr. Volker Brecht (Nuclear Magnetics Resonance, Institut fuer Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Germany) for HRESIMS measurements.

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Authors and Affiliations

  1. Pharmacognosy Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt

    Gamal A. Mohamed & Mohamed S. A. Abdelkader

  2. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

    Sabrin R. M. Ibrahim

  3. Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Nawal M. Al-Musayeib

  4. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA

    Mohamed Ghoneim

  5. National Center for Natural Products Research, and Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, 38677, USA

    Samir A. Ross

Authors
  1. Gamal A. Mohamed
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  2. Sabrin R. M. Ibrahim
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  3. Mohamed S. A. Abdelkader
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  4. Nawal M. Al-Musayeib
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  5. Mohamed Ghoneim
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  6. Samir A. Ross
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Corresponding author

Correspondence to Samir A. Ross.

Electronic supplementary material

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Experimental procedures; 1D and 2D NMR spectra and MS data of 2 and 3 (DOC 1141 kb)

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Mohamed, G.A., Ibrahim, S.R.M., Abdelkader, M.S.A. et al. Zeaoxazolinone, a new antifungal agent from Zea mays roots. Med Chem Res 23, 4627–4630 (2014). https://doi.org/10.1007/s00044-014-1026-9

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  • DOI: https://doi.org/10.1007/s00044-014-1026-9

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