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Activation of stress response axis as a key process in environment-induced sex plasticity in fish

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Abstract

The determination of sex is an important hallmark in the life cycle of organisms, in which the fate of gonads and then the individual sex are defined. In gonochoristic teleost fish, this process is characterized by a high plasticity, considering that in spite of genotypic sex many environmental factors can cause shifts from one to another molecular pathway, resulting in organisms with mismatching genotypic and phenotypic sexes. Interestingly, in most instances, both female-to-male or male-to-female sex-reversed individuals develop functional gonads with normal gametogenesis and respective progenies with full viability. The study of these mechanisms is being spread to other non-model species or to those inhabiting more extreme environmental conditions. Although water temperature is an important mechanism involved in sex determination, there are other environmental stressors affected by the climate change which are also implicated in stress response-induced masculinization in fish. In this regard, the brain has emerged as the transducer of the environment input that can influence the gonadal fate. Furthermore, the evaluation of other environmental stressors or their synergic effect on sex determination at conditions that simulate the natural environments is growing gradually. Within such scope, the concerns related to climate change impacts rely on the fact that many of biotic and abiotic parameters reported to affect sex ratios are expected to increase concomitantly as a result of increased greenhouse gas emissions and, particularly worrying, many of them are related to male bias in the populations, such as high temperature, hypoxia, and acidity. These environmental changes can also generate epigenetic changes in sex-related genes affecting their expression, with implications on sex differentiation not only of exposed individuals but also in following generations. The co-analysis of multi-stressors with potential inter- and transgenerational effects is essential to allow researchers to perform long-term predictions on climate change impacts in wild populations and for establishing highly accurate monitoring tools and suitable mitigation strategies.

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Acknowledgements

We thank Agencia Nacional de Promoción Científica y Tecnológica (Grants PICT 2015-2501 to J.I.F. and PICT 2016-0747 to P.H.S.-M.) and to Sao Paulo Research Foundation (FAPESP2014/50790-0 and 2018/20200-8 to R.S.H.). D.C.C.C. and L.F.A.P. were supported by a PhD fellowship from the National Research Council (CONICET). J.I.F. and P.H.S.-M. are members of the career of scientific researcher at the CONICET.

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  1. Salmonid Experimental Station at Campos do Jordão, UPD-CJ (APTA/SAA), Campos do Jordão, Brazil

    R. S. Hattori

  2. Laboratorio de Biología del Desarrollo, Instituto Tecnológico de Chascomús (CONICET-UNSAM), Chascomús, Argentina

    D. C. Castañeda-Cortés, L. F. Arias Padilla, P. H. Strobl-Mazzulla & J. I. Fernandino

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  1. R. S. Hattori
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Hattori, R.S., Castañeda-Cortés, D.C., Arias Padilla, L.F. et al. Activation of stress response axis as a key process in environment-induced sex plasticity in fish. Cell. Mol. Life Sci. 77, 4223–4236 (2020). https://doi.org/10.1007/s00018-020-03532-9

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