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The role of FcεRI expressed in dendritic cells and monocytes

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Abstract

Early studies regarding the function of FcεRI in dendritic cells (DCs) and monocytes have focused on its role in mediating inflammatory signaling and enhancing T cell immunity. It has been the case in part because FcεRI is the major receptor that mediates allergic inflammatory signaling in mast cells and basophils and because DCs and monocytes are antigen presenting cells capable of activating naïve and/or effector T cells. These studies have led to the general belief that FcεRI-mediated DC signaling and antigen presentation promote development and activation of Th2 cells and contribute to allergic inflammatory diseases. However, this belief has long suffered from a lack of evidence. Recently, studies have emerged that provide evidence supporting an opposing role: that FcεRI on DCs instead promotes immune homeostasis and regulation. In this review, we will update the current status of our understanding of FcεRI biology and function, with a specific focus on DCs and monocytes.

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Acknowledgments

This work is supported by the UCSF Sandler Asthma Basic Research Center and the American Heart Association.

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  1. Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, 513 Parnassus Avenue, HSE-201, San Francisco, CA, 94143, USA

    Jeoung-Sook Shin

  2. Department of Infectious Disease, Genentech, Inc., South San Francisco, CA, USA

    Alexandra M. Greer

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Shin, JS., Greer, A.M. The role of FcεRI expressed in dendritic cells and monocytes. Cell. Mol. Life Sci. 72, 2349–2360 (2015). https://doi.org/10.1007/s00018-015-1870-x

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