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Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Allergic rhinitis (AR) is an IgE-mediated inflammation which causes olfactory dysfunction. Antihistamines have been widely used to treat AR while few studies have investigated the effect of antihistamines on improving the sense of smell. In addition, the underlying mechanisms are not well elucidated. We established the ovalbumin (OVA)-induced allergic rhinitis rat model and administrated desloratadine to AR rats. The AR symptoms, serum level of OVA-specific IgE and IL-17, and expression of IL-4, IL-5 and IL-13 in nasal mucosa were measured. The olfactory dysfunction was monitored by buried food test and the expression of GluR1 was measured. Desloratadine treatment alleviated AR symptoms, decreased serum level of OVA-specific IgE and IL-17 in AR rats. Desloratadine decreased IL-4, IL-5, and IL-13 expression in nasal mucosa of AR rats. Desloratadine ameliorated olfactory dysfunction in AR rats and decreased GluR1 expression in AR rats. Desloratadine treatment alleviated AR symptoms and ameliorated olfactory dysfunction in AR rats. The expression of AMPA receptor subunit GluR1 in olfactory bulb was associated with olfactory disorder.

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Acknowledgements

None.

Funding

The study was supported by the National Natural Science Foundation of China (81770978); Shandong Key R&D Program (Public Relations of Public Welfare Science and Technology, 2018GSF118012); Shandong Medical and Health Science and Technology Development Plan Project (2016WS0268); China Postdoctoral Science Foundation (20110491558); Shandong Natural Science Foundation (ZR2016HB66).

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Authors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Qingdao, 266000, China

    Shenling Li, Xiaodan Jiang, Niankai Zhang, Yichuan Huang, Yan Jiang & Na Li

  2. Department of Anesthesiology, Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Qingdao, 266000, China

    Xiaotian Zhang

  3. Department of Otolaryngology-Head and Neck Surgery, Key Laboratory, Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Qingdao, 266000, China

    Zhiyuan Li & Jisheng Zhang

  4. Department of Pathology, Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Qingdao, 266000, China

    Han Zhao

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  1. Shenling Li
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  2. Xiaotian Zhang
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  3. Zhiyuan Li
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  4. Xiaodan Jiang
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  5. Niankai Zhang
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  6. Jisheng Zhang
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  7. Yichuan Huang
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  8. Han Zhao
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  9. Yan Jiang
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  10. Na Li
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Correspondence to Yan Jiang or Na Li.

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Li, S., Zhang, X., Li, Z. et al. Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. Arch. Immunol. Ther. Exp. 68, 6 (2020). https://doi.org/10.1007/s00005-020-00569-3

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