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Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow limitation associated with chronic inflammation. Matrix metalloproteinases (MMPs) are proteolytic enzymes that contribute to the inflammatory response in COPD and degrade extracellular matrix components. Their enzymatic activity is inhibited by a four-member family of tissue inhibitors of metalloproteinases (TIMPs). In COPD, the MMP/TIMP network, mainly MMP-9, has been repeatedly observed to be dysregulated at both the local (lung) and systemic levels. Here, we review the findings reported in numerous cross-sectional studies with our primary focus on longitudinal observations in human COPD studies. The data from longitudinal prospective studies on the MMP/TIMP network may lead to the introduction of novel prognostic biomarkers into clinical management of COPD. We address the relationship between the systemic and local lung MMP/TIMP network in COPD patients and briefly describe the involvement of microRNAs. Finally, the role of the MMP/TIMP network in COPD treatment is discussed.

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Acknowledgments

This work was supported by the project CZ.1.07/2.3.00/30.0004 and IGA PU LF 2015 020.

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Authors and Affiliations

  1. Laboratory of Immunogenomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15, Olomouc, Czech Republic

    Zdenka Navratilova & Martin Petrek

  2. Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

    Vitezslav Kolek

Authors
  1. Zdenka Navratilova
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  2. Vitezslav Kolek
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  3. Martin Petrek
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Correspondence to Martin Petrek.

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Navratilova, Z., Kolek, V. & Petrek, M. Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease. Arch. Immunol. Ther. Exp. 64, 177–193 (2016). https://doi.org/10.1007/s00005-015-0375-5

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  • DOI: https://doi.org/10.1007/s00005-015-0375-5

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