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Studies in human biliary physiology

III. The effect of bile and vitamin k on experimentally produced hemorrhagic diathesis in a human with a total external biliary fistula

  • Published:
The American Journal of Digestive Diseases

Summary

  1. 1.

    A hemorrhagic tendency was produced in two weeks in a young female with a total external biliary fistula by the feeding of a low-fat Vitamin K-deficient diet and the omission of oral bile feeding.

  2. 2.

    This bleeding diathesis was not alleviated by the oral administration of bile alone.

  3. 3.

    This bleeding diathesis was not influenced by the administration of Vitamin K concentrate alone.

  4. 4.

    The use of Vitamin K concentrate in conjunction with orally fed bile produced a cessation of bleeding in five days.

  5. 5.

    The hemorrhagic diathesis produced was accompanied by an increase in coagulation time and Quick prothrombin time.

  6. 6.

    The bile and Vitamin K therapy returned the elevated coagulation and prothrombin times to normal values eight days after the initiation of this treatment.

  7. 7.

    The blood studies in this condition indicated an alteration in only the coagulation and prothrombin times.

  8. 8.

    The Quick prothrombin time is a more delicate index of the blood changes than is the coagulation time.

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Authors and Affiliations

  1. Brooklyn, New York

    I. Charles Zuckerman, Benjamin Kogut, Mendel Jacobi & Jacob Y. Cohen

Authors
  1. I. Charles Zuckerman
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  2. Benjamin Kogut
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  3. Mendel Jacobi
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  4. Jacob Y. Cohen
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Additional information

From the Departments of Surgery and Pathology, Beth-El Hospital, Brooklyn, N. Y.

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Zuckerman, I.C., Kogut, B., Jacobi, M. et al. Studies in human biliary physiology. American Journal of Digestive Diseases 6, 332–335 (1939). https://doi.org/10.1007/BF02996496

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  • DOI: https://doi.org/10.1007/BF02996496

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