Summary
Seven patients with idiopathic Parkinson's disease were enrolled in a ten week study to evaluate the efficacy of famotidine, an histamine H2-antagonist, in the treatment of bradyphrenia. Patients received famotidine 80 mg/day for a period of six weeks and were evaluated with neuropsychological tests. Overall, patients demonstrated improvement in variables measured. Some patients also reported an improvement in their motor symptoms.
References
Alvarez EO, Banzan AM (1992) The role of histamine in the anterior hypothalamus and its functional interaction with the hippocampus on exploratory behavior in adult male rats. Behav Brain Res 48: 127–133
Coelho MH, Silva IJ, Azevedo MS, Manso CF (1991) Decrease in blood histamine in drug-treated Parkinsonian patients. Mol Chem Neuropathol 14: 77–85
Deutsch SI, Rosse RB, Kendrick KA, Fay-McCarthy M, Collins JP, Wyatt RJ (1993) Famotidine adjunctive pharmacotherapy for schizophrenia: preliminary data. Clin Neuropharmacol 16: 518–524
Kaminsky R, Moriarty TM, Bodine J, Wolf DE, Davidson M (1990) Effect of famotidine on deficit symptoms of schizophrenia. Lancet 335: 1351–1352
Martinez-Mir MI, Pollard H, Moreau J, Arrang JM, Ruat M, Traiffort E, Schwartz JC, Palacios JM (1990) Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-homan primates. Brain Res 526: 322–327
Oyewumi LK, Vollick D, Merskey H, Plumb C (1994) Famotidine as an adjunct treatment of resistant schizophrenia. J Psychiatr Neurosci 19: 145–150
Prast H, Fischer H, Phillippu A (1994) Release of acetycholine in the ventral striatum is influenced by histamine receptors. Agents Actions 41: c85-c86
Sandyk R, Kay SR (1990) The relationship of negative schizophrenia to parkinsonism. Int J Neurosci 55: 1–59
Schlicker E, Fink K, Detzner M, Gothert M (1993) Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm [Gen Sect] 93: 1–10
Sullivan EV, Shear PK, Zipursky RB, Sagar HJ, Pfefferbaum A (1994) A deficit profile of executive, memory, and motor functions in schizophrenia. Biol Psychiatry 36: 641–653
Taylor AE, Saint-Cyr JA, Lang AE (1986) Frontal lobe dysfunction in Parkinson's disease: the cortical focus of neostriatal outflow. Brain 109: 845–883
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Molinari, S.P., Kaminski, R., Di Rocco, A. et al. The use of famotidine in the treatment of Parkinson's disease: a pilot study. J Neural Transm Gen Sect 9, 243–247 (1995). https://doi.org/10.1007/BF02259665
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DOI: https://doi.org/10.1007/BF02259665