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Cyclosporin A enhances Streptozocin-induced diabetes in CD-1 mice

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Summary

Cyclosporin A (CYA), when administered to CD-1 mice treated with a subdiabetogenic dose of Streptozocin (STZ), exacerbated the STZ-induced insulitis and elevated the plasma glucose levels, parallel to a reduction of the insulin content of the pancreas. The possible mechanisms of CYA-mediated aggravation of STZ-induced diabetes are discussed.

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Authors and Affiliations

  1. First Department of Medicine, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan

    R. Iwakiri, S. Nagafuchi, E. Kounoue, S. Nakano, T. Koga, M. Nakayama, M. Nakamura & Y. Niho

Authors
  1. R. Iwakiri
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  2. S. Nagafuchi
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  3. E. Kounoue
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  4. S. Nakano
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  5. T. Koga
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  6. M. Nakayama
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  7. M. Nakamura
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  8. Y. Niho
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Additional information

The authors are grateful to M. Ohara for comments on the manuscript.

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Iwakiri, R., Nagafuchi, S., Kounoue, E. et al. Cyclosporin A enhances Streptozocin-induced diabetes in CD-1 mice. Experientia 43, 324–327 (1987). https://doi.org/10.1007/BF01945570

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  • DOI: https://doi.org/10.1007/BF01945570

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