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Decrease in adhesion of Escherichia coli to human urinary tract epithelial cells in vitro by subinhibitory concentrations of ampicillin

Geringere Haftfähigkeit von Escherichia coli am Epithel des Urogenitaltraktes bei In-vitro-Versuchen mit subinhibitorischen Ampicillin-Konzentrationen

A preliminary study

  • Synergy Between Host Defence And Antimicrobial Agents
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Summary

Low levels of ampicillin, 1/4 the minimal inhibitory concentration, decrease the ability of Escherichia coli to attach to human urinary tract epithelial cells in vitro. Such adhesion may be a virulence factor inEscherichia coli producing symptomatic urinary tract infections, since strains from the urine of patients with acute pyelonephritis and acute cystitis attach more than strains from patients with asymptomatic bacteriuria or normal faecalE. coli.

Zusammenfassung

Die Haftung vonEscherichia coli-Bakterien am Epithel des menschlichen Harntraktes wird in vitro durch subinhibitorische Ampicillin-Konzentrationen herabgesetzt. Niedrige Ampicillin-Konzentrationen (1/4 der minimalen Hemmkonzentration) verringern diese Haftfähigkeit, die ein Virulenz-Faktor von Harnwegsinfektionen sein könnte, da Stämme aus dem Urin von Patienten mit akuter Pyelonephritis und akuter Zystitis eine geringere Haftung zeigen als Stämme von Patienten mit asymptomatischer Bakteriurie oder normaler Stuhl-E. coli im Urin.

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Authors and Affiliations

  1. Department of Immunology, Institute of Medical Microbiology, Guldhedsgatan 10, 413 46, Göteborg, Sweden

    C. Svanborg-Edén &  S. Ahlstedt

  2. Department of Infectious Diseases, Östra sjukhuset, 416 85, Göteborg, Sweden

    T. Sandberg &  K. Stenqvist

Authors
  1. C. Svanborg-Edén
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  2. T. Sandberg
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  3. K. Stenqvist
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  4. S. Ahlstedt
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Svanborg-Edén, C., Sandberg, T., Stenqvist, K. et al. Decrease in adhesion of Escherichia coli to human urinary tract epithelial cells in vitro by subinhibitory concentrations of ampicillin. Infection 6 (Suppl 1), S121–S124 (1978). https://doi.org/10.1007/BF01646082

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  • DOI: https://doi.org/10.1007/BF01646082

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