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Antibakterielle Aktivität von Antibiotika in menschlicher Galle

Antibacterial activity of antibiotics in human bile

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Zusammenfassung

Zwischen der antibakteriellen Aktivität in menschlicher Galle und Bouillon bestehen zum Teil erhebliche Unterschiede. Während Penicilline und Cephalosporine gegenüber gramnegativen Keimen in Galle und Bouillon nahezu die gleiche Wirkung aufwiesen, fanden sich bei Tetracyclin ein erheblicher Wirkungsverlust, bei Aminoglykosiden erhebliche Aktivitätssteigerungen. Auch Chloramphenicol und Co-Trimoxacol haben in Galle andere minimale Hemmkonzentrationen als in Bouillon. Die Aktivitätsunterschiede zeigten eine gewisse Abhängigkeit vom pH-Wert der Galle, ohne daß sich die Unterschiede als reinen pH-Effekt erklären lassen. Die Ergebnisse sollten bei therapeutischen Empfehlungen für die Behandlung von Galleninfektionen berücksichtigt werden.

Summary

Marked differences exist between antibacterial activity in human bile and broth. Whereas penicillins and cephalosporines exhibit virtually the same activity in broth and bile, tetracycline shows a great lose, and the activity of the aminoglykosides is increased in bile. Minimal inhibitory concentrations of chlorampenicol and co-trimoxazole are also different in broth and human bile. The differences in activity are related to the pH although not all deviations can be attributed to the effect of the pH. These results should be considered when treating gall-bladder infections.

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Helm, E.B., Paulus, I., Shah, P.M. et al. Antibakterielle Aktivität von Antibiotika in menschlicher Galle. Infection 4, 94–101 (1976). https://doi.org/10.1007/BF01638724

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  • DOI: https://doi.org/10.1007/BF01638724

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