Summary
A T-cell marker was expressed by the leukemic lymphoblasts of a 14 years old boy. After 14 days of cultivation, a permanently growing lymphoblastic cell line JM, which manifested the T-cell marker over the whole period of subcultivation, was established from the blood. In vitro synchronization experiments showed that this important cell marker in the G1 phase of the cell cycle is expressed on the surface of the blasts to a reduced degree, compared to the level in the other cell cycle phases.
Zusammenfassung
Auf den Lymphoblasten eines 14jährigen Jungen mit kindlicher Leukämie wurde ein T-Zellmarker exprimiert. Es gelang, aus seinem Blut eine permanente Lymphoblastenlinie JM zu etablieren, die seit 9 Monaten noch immer den Zellmarker nachweisen läßt. Synchronisationsversuche-in vitro-ergaben, daß dieser Zellmarker auf der Oberfläche der Lymphoblasten in der G1-Phase zu einem geringeren Ausmaße exprimiert wird als in den sonstigen Zellzyklusphasen.
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Schwenk, HU., Schneider, U. Cell cycle dependency of a T-cell marker on lymphoblasts. Blut 31, 299–306 (1975). https://doi.org/10.1007/BF01634146
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DOI: https://doi.org/10.1007/BF01634146