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The electrophysiological effects of intravenous xamoterol in man

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Summary

The electrophysiological effects of xamoterol were studied in ten patients with suspected coronary artery disease by intracardiac electrography. Sino-atrial and atrioventricular conduction times were both slightly shortened by 0.1 mg/kg of xamoterol. The atrioventricular nodal refractory periods were shortened without consistent change in atrial refractoriness. This dose raised mean blood pressure by only 3 mmHg and resting heart rate by only 4 beats/min. The effects suggest a beta1 agonist activity closer to that of prenalterol than that of pindolol under conditions of rest.

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References

  1. Pouleur H, Rousseau MF, Mengeot P, Veriter C, Vincent MF, Brasseur LA (1982) Improvement of global and regional left ventricular function in patients with previous myocardial infarction by a new Beta1-adrenoceptor partial agonist, ICI 118 587. Eur Heart J 3: 123–127

    Google Scholar 

  2. Rousseau MF, Pouleur H, Vincent MF (1983) Effects of a cardioselective Beta1 partial agonist (Corwin) on left ventricular function and myocardial metabolism in patients with previous myocardial infarction. Am J Cardiol 51: 1267–1274

    Google Scholar 

  3. Detry JMR, Decoster PM, Buy JJ, Rousseau MF, Brasseur LA (1984) Antianginal effects of Corwin, a new beta-adrenoceptor partial agonist. Am J Cardiol 53: 439–443

    Google Scholar 

  4. Nuttall A, Snow HM (1982) The Cardiovascular effects of ICI 118 587: A β1-adrenoceptor partial agonist. Br J Pharmacol 77: 381–388

    Google Scholar 

  5. Marlow HF, Wardleworth AG, Booth LM (1982) The haemodynamic effects of oral doses of ICI 118 587, a β-adrenoceptor partial agonist in healthy volunteers. Br J Clin Pharmacol 13: 269p-270p

    Google Scholar 

  6. Robinson C, Birkhead J, Crook B, Jennings K, Jewitt D (1978) Clinical electrophysiological effects of atenolol — a new cardioselective betablocking agent. Br Heart J 40: 14–21

    Google Scholar 

  7. Seides SF, Josephson ME, Batsford WP, Weisfogel GM, Lau SH, Damato AN (1974) The electrophysiology of propranolol in man. Am Heart J 88: 733–741

    Google Scholar 

  8. Berkowitz WD, Wit AL, Lau SH, Steiner C, Damato AN (1969) The effects of propranolol on cardiac conduction. Circulation 40: 835–862

    Google Scholar 

  9. Rizzon P, Di Biase M, Chiddo A, Mastrangelo D, Sorgente L (1978) Electrophysiological properties of intravenous metoprolol in man. Br Heart J 40: 650–655

    Google Scholar 

  10. Marchlinski FE, Buxton AE, Waxman HL, Josephson ME (1984) Electrophysiologic effects of intravenous metoprolol. Am Heart J 107: 1125–1131

    Google Scholar 

  11. Hombach V, Braun V, Hopp HW, Gil-Sanchez D, Behrenbeck DW, Tauchert M, Hilger HH (1982) Electrophysiological effects of cardioselective and non-cardioselective β-adrenoceptor blockers with and without ISA at rest and during exercise. Br J Clin Pharmacol 13: 285s-293s

    Google Scholar 

  12. Capucci A, Frabetti L, Melandri G, Magnani B (1983) Electrophysiologic properties of prenalterol. International J Cardiol 2: 391–400

    Google Scholar 

  13. Barlow JJ, Main BG, Snow HM (1981) β-Adrenoceptor stimulant properties of amidoalkylamino-substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols. J Med Chem 24: 315–322

    Google Scholar 

  14. Jennings G, Bobik A, Oddie C, Restall R (1984) Cardioselectivity, kinetics, haemodynamics, and metabolic effects of xamoterol. Clin Pharmacol Ther 35: 594–603

    Google Scholar 

  15. Harley A, Coverdale HA (1981) The electrophysiological effects of intravenous labetalol in man. Eur J Clin Pharmacol 20: 241–244

    Google Scholar 

  16. Ikaheimo MJ, Jakkunen JT (1964) The effects of beta1-adrenoceptor partial agonist ICI 118 587 on left ventricular function in patients with coronary heart disease. International J Cardiol 5: 339–349

    Google Scholar 

  17. Mason JW, Winkle M, Meffin PJ, Harrison DC (1978) Electrophysiological effects of acebutolol. Br Heart J 40: 35–40

    Google Scholar 

  18. Vargas G, Akhtar M, Damato AN (1975) Electrophysiological effects of isoproterenol on cardiac conduction system in man. Am Heart J 90: 25–34

    Google Scholar 

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Authors and Affiliations

  1. Liverpool Regional Adult Cardiothoracic Unit, Liverpool, U.K.

    R. J. Bowes, P. C. Gautam, D. R. Graham & A. Harley

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  1. R. J. Bowes
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  2. P. C. Gautam
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  3. D. R. Graham
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  4. A. Harley
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Bowes, R.J., Gautam, P.C., Graham, D.R. et al. The electrophysiological effects of intravenous xamoterol in man. Eur J Clin Pharmacol 29, 731–734 (1986). https://doi.org/10.1007/BF00615969

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  • DOI: https://doi.org/10.1007/BF00615969

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