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The Hypercycle

A principle of natural self-organization Part C: The realistic hypercycle

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Abstract

The proposed model for a ‘realistic hypercycle’ is closely associated with the molecular organization of a primitive replication and translation apparatus. Hypercyclic organization offers selective stabilization and evolutive adaptation for all geno- and phenotypic constituents of the functionally linked ensemble. It originates in a molecular quasi-species and evolves by way of mutation and gene duplication to greater complexity. Its early structure appears to be reflected in: the assignment of codons to amino acids, in sequence homologies of tRNAs, in dual enzymic functions of replication and translation, and in the structural and functional organization of the genome of the prokaryotic cell.

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References

  1. Woese, C.R.: Nature 226, 817 (1970)

    Article  CAS  PubMed  Google Scholar 

  2. Fuller, W., Hodgson, A.: ibid. 215, 817 (1967)

    Article  CAS  PubMed  Google Scholar 

  3. Crick, F.H.C.: J. Mol. Biol. 38, 367 (1968)

    Article  CAS  PubMed  Google Scholar 

  4. Miller, S.L., Orgel, L.E.: The Origins of Life on Earth. Englewood Cliffs, N.J.: Prentice Hall 1973

    Google Scholar 

  5. Oró, J., Kimball, A.P.: Biochem. Biophys. Res. Commun. 2, 407 (1960); Oró, J.: Nature 191, 1193 (1961)

    Article  Google Scholar 

  6. Lewis, J.B., Doty, P.: ibid. 225, 510 (1970)

    CAS  Google Scholar 

  7. Uhlenbeck, O.C., Baller, J., Doty, P.: ibid. 225, 508 (1970)

    CAS  Google Scholar 

  8. Grosjean, H., Söll, D.G., Crothers, D.M.: J. Mol. Biol. 103, 499 (1976)

    Article  CAS  PubMed  Google Scholar 

  9. Coutts, S.M.: Biochim. Biophys. Acta 232, 94 (1971)

    Article  CAS  PubMed  Google Scholar 

  10. Kvenvolden, K.A., et al.: Nature 228, 923 (1970)

    Article  CAS  PubMed  Google Scholar 

  11. Oró, J., et al.: ibid. 230, 105 (1971); Cromin, J.R., Moore, C.B.: Science 172, 1327 (1971)

    Article  PubMed  Google Scholar 

  12. Rossman, M.G., Moras, D., Olsen, K.W.: Nature 250, 194 (1974)

    Article  Google Scholar 

  13. Walker, G.W.R.: BioSystems 9, 139 (1977)

    Article  CAS  PubMed  Google Scholar 

  14. Biebricher, Ch., Eigen, M., Luce, R.: in preparation

  15. Erhan, S., Greller, L.D., Rasco, B.: Z. Naturforsch. 32c, 413 (1977)

    CAS  Google Scholar 

  16. Dayhoff, M.O.: Atlas of Protein Sequence and Structure, Vol. 5, Suppl. 2, p. 271 (1976)

    Google Scholar 

  17. Jukes, T.H.: Nature 246, 22 (1973); Holmquist, R., Jukes, T.H., Pangburn, S.: J. Mol. Biol. 78, 91 (1973)

    Article  CAS  PubMed  Google Scholar 

  18. Fox, G.E., et al.: Proc. Nat. Acad. Sci. USA 74, 4537 (1977)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Uramer, F.R., et al.: J. Mol. Biol. 89, 719 (1974)

    Article  Google Scholar 

  20. Chothia, C.: ibid 75, 295 (1973)

    Article  CAS  PubMed  Google Scholar 

  21. Chou, P.Y., Fasman, G.D.: ibid. 115, 135 (1977)

    Article  CAS  PubMed  Google Scholar 

  22. Levitt, M., Chothia, C.: Nature 261, 552 (1976)

    Article  CAS  PubMed  Google Scholar 

  23. Gutte, B.: J. Biol. Chem. 252, 663 (1977)

    CAS  PubMed  Google Scholar 

  24. Rigler, R.: personal communication; Rigler, R., Ehrenberg, M., Wintermeyer, W., in: Molecular Biology, Biochemistry and Biophysics Vol. 24, p.219

  25. Olson, T., et al.: J. Mol. Biol. 102, 193 (1976)

    Article  CAS  PubMed  Google Scholar 

  26. Crothers, D.M., Seno, T., Söll, D.G.: Proc. Nat. Acad. Sci. USA 69, 3063 (1972)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Biebricher, Ch., Druminski, M.: ibid (submitted)

    Article  Google Scholar 

  28. Wahba, A.J., et al.: J. Biol. Chem. 249, 3314 (1974)

    CAS  PubMed  Google Scholar 

  29. Blumenthal, T., Lauders, T.A., Weber, K.: Proc. Nat. Acad. Sci. USA 69, 1313 (1972)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Biebricher, Ch.: in preparation

  31. Meinhardt, H., in: Synergetics, p. 214 (ed. H. Haken), Berlin-Heidelberg-New York: Springer 1977

    Chapter  Google Scholar 

  32. Fox, S.W., Dose, K.: Molecular Evolution and the Origin of Life. San Francisco: Freeman 1972

    Google Scholar 

  33. Dose, K., Rauchfuss, H.: Chemische Evolution und der Ursprung lebender Systeme. Stuttgart: Wissensch. Verlagsges. 1975

    Google Scholar 

  34. Onsager, L., in: Quantum Statistical Mechanics in Natural Sciences, p. 1 (ed. B. Kursunoglu). New York-London: Plenum Press 1973

    Google Scholar 

  35. Lasaga, A.C., Holland, H.D., Dwyer, M.O.: Science 174, 53 (1971)

    Article  CAS  PubMed  Google Scholar 

  36. Schmidt, E.: Z. Ges. Eis- u. Kälteindustrie 44, 163 (1937)

    Google Scholar 

  37. Kuhn, H., in: Synergetics, p. 200 (ed. H. Haken). Berlin-Heidelberg-New York: Springer 1977

    Chapter  Google Scholar 

  38. Plato: Timaios

  39. Schuster, P., Sigmund, K.: in preparation

  40. Urbanke, W., Maass, G.: to be published

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Authors and Affiliations

  1. Max-Planck-Institut für biophysikalische Chemie, D-3400, Göttingen

    Manfred Eigen

  2. Institut für theoretische Chemie und Strahlenchemie der Universität, A-1090, Wien

    Peter Schuster

Authors
  1. Manfred Eigen
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  2. Peter Schuster
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Additional information

This work was greatly stimulated by discussion with Francis Crick, Stanley Miller, and Lesile orgel; which for us meant some ‘selection pressure’ to look for more continuity in molecular evolution. Especiely helpful were suggestions and comments by Ch. Biebricher, I. Epstein, B. Gutte, D. Pörschke, K., Sigmund, P. Wolley, and R. Wolff.

The work at Vienna was supported by the Austrian ‘Fonds zur Förderung der wissenschaftlichen Forschung’ (Project Nr. 3502). Ruthlid Winkler-Oswatitsch designed most of the illustrations and was always a patient and critical discussant. Thanks to all for their help.

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Eigen, M., Schuster, P. The Hypercycle. Naturwissenschaften 65, 341–369 (1978). https://doi.org/10.1007/BF00439699

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