Abstract
The blood–brain barrier and the quick medication clearance into blood circulation following the administration of standard dosage form place restrictions on the treatment of brain-related disorders. The transport of drugs to the brain has been shown to increase with the use of block copolymers in past studies due to better stability, targetability and extensive circulation period. Owing to the complex formation, functionalisation, dosage mitigation and kinetics for the rate of release processes, improvements of block copolymers exhibit improved solubility and decreased cytotoxicity. The focus is on block copolymers that can be used as translational nanomedicines synthesised via complex multimolecular interactions among the polymers and the loaded pharmaceuticals. According to the sort of polymeric interaction with the biological interface, the elements associated with the creation of effective carriers are explained in depth, with a focus on the chemical engineering of the block copolymers. Block copolymers have such diverse functions that they purposefully pass through the biomembrane as polymeric nanoparticles, polymersomes and micelles utilising various pathways, including transcellular- and receptor-mediated transportation systems to achieve the targeted neural network, integration of stimuli-sensitive moieties, complexation of active ligands and imaging moieties in copolymers and the conjugation of cargo molecules with the core-forming block via responsive smart linkers. This chapter provides instances of corona-forming blocks for the transfer of drugs to the brain and brain imaging with neuroprotective effects.
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Abbreviations
- AD:
-
Alzheimer’s disease
- Aβ:
-
Amyloid-beta (Aβ)
- ApoE:
-
Apo-lipoprotein-E
- APH-1105:
-
Amyloid precursor protein secretase
- ALNTR0 :
-
a TTR mRNA-specific siRNA
- AuNPs:
-
Gold nanoparticle
- BBB:
-
Blood–brain barrier
- β-OMF:
-
Beta barrel outer membrane protein-F
- CNS:
-
Central nervous system
- CED:
-
Convention-Enhanced Distribution
- CNM-Au8:
-
Nanocrystalline gold
- DHBC:
-
Double hydrophilic block co-polymers
- HD:
-
Huntington’s disease
- LNPs:
-
Lipid nanoparticles
- LDLR:
-
Low-density lipoprotein receptor
- MS:
-
Multiple sclerosis
- MRS:
-
Magnetic Resonance Spectroscopy (MRS)
- MAPHP:
-
2-methyl -N-3(aminopropyl)-3 hydroxy-4 pyridinon (MAPHP)
- miRNAs:
-
MicroRNAs
- NPs:
-
Nanoparticles
- OL:
-
Odorranalectin
- ROS:
-
Reactive oxygen species
- PD:
-
Parkinson’s disease
- PEO:
-
Polyethylene oxide
- PPO:
-
Polypropylene oxide
- PNIPAM:
-
Poly(N-isopropylacrylamide)
- PS-b-PDMS:
-
Poly (styrene-block-dimethylsiloxane)
- PLGA:
-
Poly-D, L lactic-co-glycolic acid
- PS-b-PDMS:
-
Poly styrene-block-dimethylsiloxane
- PLA:
-
Polylactide
- PEG:
-
Polyethylene glycol
- PS80:
-
Polysorbate P80
- PICM:
-
Polyion complexes micelles
- TBZ:
-
Tetrabenazine (TBZ)
- TPGS:
-
d-α tocopherol polyethylene glycol 1000 succinate
- TH1:
-
T helper cell type-1
- TH2:
-
T-helper cell type-2
- VMAT2:
-
Vesicular monoamine transporter
- WGA:
-
Wheat germ agglutinin
- WHO:
-
World Health Organisation
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Kaur, S. et al. (2023). Role of Co-Block Polymers in the Treatment of Neurodegenerative Diseases. In: Mishra, N., Pandey, V. (eds) Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications. Springer, Singapore. https://doi.org/10.1007/978-981-99-6917-3_6
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