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Controlled Drug Delivery System

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Advanced Drug Delivery

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 26))

Abstract

This comprehensive chapter delves into the world of controlled drug delivery systems, exploring their fundamental aspects, advancements, and future possibilities. The chapter begins by emphasizing the importance of controlled drug delivery in optimizing therapeutic outcomes and enhancing patient compliance. Various drug delivery systems are discussed, including oral, injectable, transdermal, and implantable systems, each offering unique characteristics and applications. The working mechanisms of these systems are thoroughly examined, including diffusion-controlled, dissolution-controlled, osmotic pressure-controlled, and targeted drug delivery mechanisms. The advantages of controlled drug delivery systems are highlighted, such as prolonged drug release, improved therapeutic efficacy, reduced dosing frequency, minimized side effects, and increased patient convenience. However, challenges and limitations also exist, requiring attention and consideration. Formulation complexities, manufacturing intricacies, regulatory considerations, and patient variability are hurdles in developing and implementing controlled drug delivery systems. Recent advancements in the field are explored, including the emergence of intelligent drug delivery systems that respond to specific cues, nanotechnology-based platforms enabling precise drug targeting, innovative combination therapy approaches, and bio-responsive drug delivery systems that adapt to physiological changes. These advancements pave the way for promising future applications, such as personalized medicine, targeted drug delivery, remote-controlled systems, and the integration of bioprinting and 3D printing technologies. In conclusion, this chapter provides a comprehensive understanding of controlled drug delivery systems, showcasing their potential to revolutionize drug therapy and improve patient outcomes. Researchers and practitioners can unlock new avenues in pharmaceutical science and create innovative solutions for controlled drug delivery by addressing the challenges, harnessing recent advancements, and exploring prospects.

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, St. John’s University, New York, USA

    Akhilraj Pillai

  2. Resolved Diagnostic Pvt Ltd., Mumbai, India

    Dhanashree Bhande

  3. Scientity Services, Thane, India

    Vinal Pardhi

Authors
  1. Akhilraj Pillai
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  2. Dhanashree Bhande
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  3. Vinal Pardhi
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Corresponding author

Correspondence to Vinal Pardhi .

Editor information

Editors and Affiliations

  1. Department of Engineering Design, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India

    Tuhin Subhra Santra

  2. Department of Engineering Design, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India

    Ashwini Uma Surendra Shinde

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Pillai, A., Bhande, D., Pardhi, V. (2023). Controlled Drug Delivery System. In: Santra, T.S., Shinde, A.U.S. (eds) Advanced Drug Delivery. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 26. Springer, Singapore. https://doi.org/10.1007/978-981-99-6564-9_11

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