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Treatment of Liver and Gastric Cancer Using Nanoemulsion

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Current Trends in Green Nano-emulsions

Part of the book series: Smart Nanomaterials Technology ((SNT))

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Abstract

Cancer is one of the leading causes of death worldwide. Current chemotherapy challenges the lack of selectivity, cytotoxicity, the development of multi-drug resistance, and the proliferation of stem-like cells. One of the leading causes of new cancer cases and cancer-related fatalities is a group of deadly malignant tumors known as liver and gastric cancer. Advanced gastric cancer is classified as having liver metastases and is one of the deadliest conditions with a dismal prognosis. As gastric cancer with liver metastases is incurable, systematic chemotherapy is the primary line of treatment, although surgery is typically used to relieve severe gastrointestinal symptoms. The main method for delivering various medications, nucleic acids, and imaging agents is nanoemulsion (NE). Nevertheless, NE is created through many functions, including surface changes and the encapsulation of active cancer-fighting substances. Because of their excellent characteristics to solubilize hydrophobic chemotherapeutics, thermodynamic stability, biocompatibility, and target ability, NEs are an appealing platform for cancer treatment. With their submicron-dispersed colloids in the continuous phase, NEs may be able to perform various tasks, which helps to overcome biological obstacles that prevent traditional chemotherapeutic drug delivery from reaching the target location of cancers. This chapter provides a brief overview of the use of NEs in treating gastric and liver cancer.

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Authors and Affiliations

  1. Division of Research and Innovation, School of Applied and Life Sciences, Uttaranchal University, Arcadia Grant, P.O. Chandanwari, Premnagar, Dehradun, 248007, Uttarakhand, India

    Sapna Yadav, Aashna Sinha, Atreyi Pramanik, Pranchal Rajput, Sujata Jayaraman, Anish Kumar Pal, Kundan Kumar Chaubey & Upendra Singh

  2. Department of Biotechnology, GLA University, Uttar Pradesh, Mathura, 281406, India

    Manjari Bhatia

  3. Department of Industrial Chemistry, Centre of Excellence in Nanotechnology, Addis Ababa Sciences and Technology University, P.O. Box 16417, Addis Ababa, Ethiopia

    Rakesh Kumar Bachheti

  4. Department of Environment Science, Graphic Era University, Dehradun, 248002, Uttarakhand, India

    Archana Bachheti

  5. School of Basic and Applied Sciences, Sanskriti University, Mathura, 281401, Uttar Pradesh, India

    Kundan Kumar Chaubey

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  1. Sapna Yadav
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  2. Manjari Bhatia
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  3. Aashna Sinha
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  7. Anish Kumar Pal
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  8. Kundan Kumar Chaubey
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  9. Upendra Singh
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  10. Rakesh Kumar Bachheti
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  11. Archana Bachheti
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Correspondence to Kundan Kumar Chaubey .

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Editors and Affiliations

  1. Wolaita Sodo University, Wolaita, Ethiopia

    Azamal Husen

  2. Department of Industrial Chemistry, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia

    Rakesh Kumar Bachheti

  3. Department of Environment Science, Graphic Era University, Dehradun, Uttarakhand, India

    Archana Bachheti

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Yadav, S. et al. (2023). Treatment of Liver and Gastric Cancer Using Nanoemulsion. In: Husen, A., Bachheti, R.K., Bachheti, A. (eds) Current Trends in Green Nano-emulsions. Smart Nanomaterials Technology. Springer, Singapore. https://doi.org/10.1007/978-981-99-5398-1_11

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