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Plant-Derived Bioactive Compounds as Potential ACE-2 Inhibitors Against SARS-CoV-2 Infection

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Ethnopharmacology and Drug Discovery for COVID-19: Anti-SARS-CoV-2 Agents from Herbal Medicines and Natural Products

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) resulted in the COVID-19 pandemic associated with severe morbidity, high mortality and adverse socioeconomic consequences across the world. Besides the development of effective vaccines for protecting individuals that are at higher risk, different therapeutic modalities have been continuously explored for the treatment of diseased persons to minimize the negative health and socioeconomic impacts of this highly fatal infection. Restricting the dissemination of SARS-COV-2 across the human population is a global challenge for health-care authorities. Therefore an array of experimental and clinical studies have been conducted to screen various natural, semi-synthetic and synthetic substances for prospective therapeutic potential against SARS-COV-2 infection. Based upon its causal role in the entrance of SARS-COV-2 into the host cells, ACE-2 has become the focus of drug development against COVID-19 infection. Accordingly, the inhibition of ACE-2 and viral S protein binding using bioactive natural products offers an efficient treatment strategy for COVID-19 infection. Although a wide range of natural products including alkaloids, flavonoids, phenols and terpenoids has been linked with ACE-2 blockage using in vitro and in silico studies, the effectiveness and safety of natural bioactive substances have not been validated. Therefore, natural compounds with potential ACE-2 inhibitory activity require detailed pharmacokinetic and safety evaluation through controlled clinical studies. This chapter discusses the various screening techniques and major ACE-2 inhibitory bioactive natural products in the context of SARS-CoV-2 infection.

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Authors and Affiliations

  1. Pharmacology and Toxicology Section, University of Veterinary and Animal Sciences, Lahore, Jhang Campus, Jhang, Pakistan

    Muhammad Adil

  2. Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea

    Pragya Tiwari

  3. Department of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan

    Jen-Tsung Chen

  4. Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan

    Shamsa Kanwal

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  1. Muhammad Adil
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  2. Pragya Tiwari
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  3. Jen-Tsung Chen
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  4. Shamsa Kanwal
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Correspondence to Muhammad Adil or Pragya Tiwari .

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Editors and Affiliations

  1. Department of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan

    Jen-Tsung Chen

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Adil, M., Tiwari, P., Chen, JT., Kanwal, S. (2023). Plant-Derived Bioactive Compounds as Potential ACE-2 Inhibitors Against SARS-CoV-2 Infection. In: Chen, JT. (eds) Ethnopharmacology and Drug Discovery for COVID-19: Anti-SARS-CoV-2 Agents from Herbal Medicines and Natural Products. Springer, Singapore. https://doi.org/10.1007/978-981-99-3664-9_8

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