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Gut Microbiota and Its Role in Human Metabolic Disorders

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Role of Microbes in Sustainable Development

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Abstract

Gut microbiota is a collective population of all the microbial communities that live in the gastrointestinal tract of humans. It provides a range of structural, protective, and metabolic functions to the human host. The contribution of gut microbiota in human metabolic health is revealed by research findings based on omics, cellular, and observational studies. Microbial metabolites are important for the normal functioning of the host, and any disrupted production of metabolites leads to the emergence of common metabolic disorders like type 2 diabetes, obesity, malnutrition, non-alcoholic fatty liver disease, and cardio-metabolic disorder. Previously, gut microbiota studies were focused on the digestive and absorptive functions, but now the research is moving forward toward descriptive microbiome analysis that effect studies with new insights. The current study focuses on the role of gut microbes in host metabolism and the depiction of the role of microbial metabolites in host function, defining their targets. Here we highlighted a few microbiota-based emerging therapeutics for metabolic disorders that aim to enhance metabolic health. This knowledge will surely guide to define personalized, microbiota-based therapies for the improvement in human health.

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The authors do not have any potential competing interests.

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Authors and Affiliations

  1. Laboratory of Enzymology and Gut Microbiology, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, India

    Asha Yadav, Shreya Vishwas Mohite, Arush Behl, Pratik Balwant Shinde & Krishna Kant Sharma

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  1. Asha Yadav
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  2. Shreya Vishwas Mohite
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  3. Arush Behl
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  4. Pratik Balwant Shinde
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  5. Krishna Kant Sharma
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Correspondence to Krishna Kant Sharma .

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Editors and Affiliations

  1. INSA Senior Scientist and Professor Emeritus, Panjab University, Chandigarh, Chandigarh, India

    R.C. Sobti

  2. Former Vice Chancellor, Central University, Haryana, India

    Ramesh Chander Kuhad

  3. Professor Emeritus, University of Delhi, New Delhi, Delhi, India

    Rup Lal

  4. Department of Microbiology, Panjab University, Chandigarh, Chandigarh, India

    Parveen Rishi

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Yadav, A., Mohite, S.V., Behl, A., Shinde, P.B., Sharma, K.K. (2023). Gut Microbiota and Its Role in Human Metabolic Disorders. In: Sobti, R., Kuhad, R.C., Lal, R., Rishi, P. (eds) Role of Microbes in Sustainable Development. Springer, Singapore. https://doi.org/10.1007/978-981-99-3126-2_14

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