Abstract
Nanomaterial-based point-of-care (POC) diagnostic devices have revolutionized healthcare monitoring by simultaneously miniaturizing the detection module and improving its sensitivity to detect a particular disease. In healthcare, POC testing (POCT) follows ASSURED criteria for diagnosis of different diseases near the place and time of patient care. Among all types of biosensors, optical biosensors offer simplicity and quick detection method, instrument-free naked eye detection, and options of noninvasive imaging. Use of optically active nanomaterial is one of the most promising candidates for the noninvasive POC diagnosis of diseases. In this chapter, the recent advances in applications of optically active nanomaterials for the diagnosis of different diseases like cancer, cardiovascular diseases, neurodegenerative diseases, and multiplexing are discussed.
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References
Adegoke O, Morita M, Kato T, Ito M, Suzuki T, Park EY (2017) Localized surface plasmon resonance-mediated fluorescence signals in plasmonic nanoparticle-quantum dot hybrids for ultrasensitive zika virus RNA detection via hairpin hybridization assays. Biosens Bioelectron 94:513–522. https://doi.org/10.1016/j.bios.2017.03.046
Akhtar MH, Hussain KK, Gurudatt NG, Chandra P, Shim Y-B (2018) Ultrasensitive dual probe immunosensor for the monitoring of nicotine induced-brain derived neurotrophic factor released from cancer cells. Biosens Bioelectron 116:108
Alafeef M, Moitra P, Dighe K, Pan D (2021) RNA-extraction-free Nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19. Nat Protoc 16(6):3141–3162. https://doi.org/10.1038/s41596-021-00546-w
Alqasaimeh M, Heng LY, Ahmad M, Raj ASS, Ling TL (2014) A large response range reflectometric urea biosensor made from silica-gel nanoparticles. Sensors (Basel) 14(7):13186–13209. https://doi.org/10.3390/s140713186
Alsunaidi B, Althobaiti M, Tamal M, Albaker W, Al-Naib I (2021) A review of non-invasive optical systems for continuous blood glucose monitoring. Sensors 21(20):6820. https://doi.org/10.3390/s21206820
Baptista PV, Koziol-Montewka M, Paluch-Oles J, Doria G, Franco R (2006) Gold-nanoparticle-probe–based assay for rapid and direct detection of mycobacterium tuberculosis DNA in clinical samples. Clin Chem 52(7):1433–1434. https://doi.org/10.1373/clinchem.2005.065391
Bilal M, Barani M, Sabir F, Rahdar A, Kyzas GZ (2020) Nanomaterials for the treatment and diagnosis of Alzheimer’s disease: an overview. NanoImpact 20:100251. https://doi.org/10.1016/j.impact.2020.100251
Borisov SM, Wolfbeis OS (2008) Optical biosensors. Chem Rev 108(2):423–461. https://doi.org/10.1021/cr068105t
Botewad SN, Pahurkar VG, Muley GG, Gaikwad DK, Bodkhe GA, Shirsat MD, Pawar PP (2020) PANI-ZnO cladding-modified optical fiber biosensor for urea sensing Based on evanescent wave absorption. Front Mater 7:184. https://doi.org/10.3389/fmats.2020.00184
Campion A, Kambhampati P (1998) Surface-enhanced Raman scattering. Chem Soc Rev 27(4):241–250. https://doi.org/10.1039/A827241Z
Chandra P, Das D, Abdelwahab AA (2010) Gold nanoparticles in molecular diagnostics and therapeutics. Dig J Nanomater Biostruct 5:363
Chandra P, Prakash R (2020) Nanobiomaterial engineering. Springer, Singapore. https://doi.org/10.1007/978-981-32-9840-8
Chen H, Das A, Bi L, Choi N, Moon J-I, Wu Y, Park S, Choo J (2020) Recent advances in surface-enhanced Raman scattering-based microdevices for point-of-care diagnosis of viruses and bacteria. Nanoscale 12(42):21560–21570. https://doi.org/10.1039/d0nr06340a
Chen L, Feng A, Wang M, Liu J, Hong W, Guo X, Xiang D (2018) Towards single-molecule optoelectronic devices. Sci China Chem 61(11):1368–1384. https://doi.org/10.1007/s11426-018-9356-2
Dinter F, Burdukiewicz M, Schierack P, Lehmann W, Nestler J, Dame G, Rödiger S (2019) Simultaneous detection and quantification of DNA and protein biomarkers in spectrum of cardiovascular diseases in a microfluidic microbead chip. Anal Bioanal Chem 411(29):7725–7735. https://doi.org/10.1007/s00216-019-02199-x
Du H, Chen R, Du J, Fan J, Peng X (2016) Gold nanoparticle-based colorimetric recognition of creatinine with good selectivity and sensitivity. Ind Eng Chem Res 55(48):12334–12340. https://doi.org/10.1021/acs.iecr.6b03433
Fu X, Cheng Z, Yu J, Choo P, Chen L, Choo J (2016) A SERS-based lateral flow assay biosensor for highly sensitive detection of HIV-1 DNA. Biosens Bioelectron 78:530–537. https://doi.org/10.1016/j.bios.2015.11.099
Gao Y, Zhang C, Yang Y, Yang N, Lu S, You T, Yin P (2021) A high sensitive glucose sensor based on Ag nanodendrites/Cu mesh substrate via surface-enhanced Raman spectroscopy and electrochemical analysis. J Alloys Compd 863:158758. https://doi.org/10.1016/j.jallcom.2021.158758
Gendelman HE, Anantharam V, Bronich T, Ghaisas S, Jin H, Kanthasamy AG, Liu X, McMillan J, Mosley RL, Narasimhan B, Mallapragada SK (2015) Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases. Nanomedicine 11(3):751–767. https://doi.org/10.1016/j.nano.2014.12.014
Gloeckler Ries LA, Reichman ME, Lewis DR, Hankey BF, Edwards BK (2003) Cancer survival and incidence from the surveillance, epidemiology, and end results (SEER) program. Oncologist 8(6):541–552. https://doi.org/10.1634/theoncologist.8-6-541
Gonzalez JM, Francis B, Burda S, Hess K, Behera D, Gupta D, Agarwal AN, Verma I, Verma A, Myneedu VP, Niedbala S, Laal S (2014) Development of a POC test for TB based on multiple immunodominant epitopes of M. tuberculosis specific cell-wall proteins. PLoS One 9(9):e106279. https://doi.org/10.1371/journal.pone.0106279
Gulland A (2014) Global cancer prevalence is growing at “alarming pace,” says WHO. BMJ 348:g1338. https://doi.org/10.1136/bmj.g1338
Hicks JM (1984) Fluorescence immunoassay. Hum Pathol 15(2):112–116. https://doi.org/10.1016/s0046-8177(84)80049-0
Homola J, Vaisocherová H, Dostálek J, Piliarik M (2005) Multi-analyte surface plasmon resonance biosensing. Methods 37(1):26–36. https://doi.org/10.1016/j.ymeth.2005.05.003
Hong B, Kang KA (2006) Biocompatible, nanogold-particle fluorescence enhancer for fluorophore mediated, optical immunosensor. Biosens Bioelectron 21(7):1333–1338. https://doi.org/10.1016/j.bios.2005.04.007
Hu J, Cui X, Gong Y, Xu X, Gao B, Wen T, Lu TJ, Xu F (2016) Portable microfluidic and smartphone-based devices for monitoring of cardiovascular diseases at the point of care. Biotechnol Adv 34(3):305–320. https://doi.org/10.1016/j.biotechadv.2016.02.008
Hwang SG, Ha K, Guk K, Lee DK, Eom G, Song S, Kang T, Park H, Jung J, Lim E-K (2018) Rapid and simple detection of Tamiflu-resistant influenza virus: development of oseltamivir derivative-based lateral flow biosensor for point-of-care (POC) diagnostics. Sci Rep 8(1):12999. https://doi.org/10.1038/s41598-018-31311-x
Inci F, Tokel O, Wang S, Gurkan UA, Tasoglu S, Kuritzkes DR, Demirci U (2013) Nanoplasmonic quantitative detection of intact viruses from unprocessed whole blood. ACS Nano 7(6):4733–4745. https://doi.org/10.1021/nn3036232
Kim H, Lee JU, Song S, Kim S, Sim SJ (2018) A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer’s disease biomarkers. Biosens Bioelectron 101:96–102. https://doi.org/10.1016/j.bios.2017.10.018
Kumar A, Purohit B, Mahato K, Mahapatra S, Srivastava A, Chandra P (2020) Bio-nano-interface engineering strategies of AuNPs passivation for next-generation biomedical applications. In: Biointerface engineering: prospects in medical diagnostics and drug delivery. Springer, Singapore, pp 215–231. https://doi.org/10.1007/978-981-15-4790-4_10
Lathika S, Raj A, Sen K, A. (2021) LSPR based on-Chip detection of dengue NS1 antigen in whole blood. RSC Adv 11(53):33770–33780. https://doi.org/10.1039/D1RA05009E
Le LV, Chendke GS, Gamsey S, Wisniewski N, Desai TA (2020) Near-infrared optical nanosensors for continuous detection of glucose. J Diabetes Sci Technol 14(2):204–211. https://doi.org/10.1177/1932296819886928
Le T, Adamiak B, Benton DJ, Johnson CJ, Sharma S, Fenton R, McCauley JW, Iqbal M, Cass AEG (2014) Aptamer-based biosensors for the rapid visual detection of flu viruses. Chem Commun 50(98):15533–15536. https://doi.org/10.1039/C4CC07888H
Lee H-A, Lin P-Y, Solomatina AI, Koshevoy IO, Tunik SP, Lin H-W, Pan S-W, Ho M-L (2022) Glucose sensing in human whole blood based on near-infrared phosphors and outlier treatment with the programming language “R”. ACS Omega 7(1):198–206. https://doi.org/10.1021/acsomega.1c04344
Lee SH, Hwang J, Kim K, Jeon J, Lee S, Ko J, Lee J, Kang M, Chung DR, Choo J (2019) Quantitative serodiagnosis of scrub typhus using surface-enhanced Raman scattering-based lateral flow assay platforms. Anal Chem 91(19):12275–12282. https://doi.org/10.1021/acs.analchem.9b02363
Lee S-W, Ahmed S, Wang T, Park Y, Matsuzaki S, Tatsumi S, Matsumoto S, Korposh S, James S (2021) Label-free creatinine optical sensing using molecularly imprinted titanium dioxide-polycarboxylic acid hybrid thin films: a preliminary study for urine sample analysis. Chemosensors 9(7):185. https://doi.org/10.3390/chemosensors9070185
Li M, Cushing SK, Liang H, Suri S, Ma D, Wu N (2013) Plasmonic nanorice antenna on triangle nanoarray for surface-enhanced Raman scattering detection of hepatitis B virus DNA. Anal Chem 85(4):2072–2078. https://doi.org/10.1021/ac303387a
Li M, Singh R, Marques C, Zhang B, Zhang B, Kumar S, Kumar S (2021) 2D material assisted SMF-MCF-MMF-SMF Based LSPR sensor for creatinine detection. Opt Express 29(23):38150–38167. https://doi.org/10.1364/OE.445555
Li Z, Leustean L, Inci F, Zheng M, Demirci U, Wang S (2019) Plasmonic-based platforms for diagnosis of infectious diseases at the point-of-care. Biotechnol Adv 37(8):107440. https://doi.org/10.1016/j.biotechadv.2019.107440
Liu H, Dai E, Xiao R, Zhou Z, Zhang M, Bai Z, Shao Y, Qi K, Tu J, Wang C, Wang S (2021) Development of a SERS-based lateral flow immunoassay for rapid and ultra-sensitive detection of anti-SARS-CoV-2 IgM/IgG in clinical samples. Sensors Actuators B Chem 329:129196. https://doi.org/10.1016/j.snb.2020.129196
Liu J, Siavash Moakhar R, Sudalaiyadum Perumal A, Roman HN, Mahshid S, Wachsmann-Hogiu S (2020) An AgNP-deposited commercial electrochemistry test strip as a platform for urea detection. Sci Rep 10(1):9527. https://doi.org/10.1038/s41598-020-66422-x
MacBeath G (2002) Protein microarrays and proteomics. Nat Genet 32(Suppl):526–532. https://doi.org/10.1038/ng1037
Mahato K, Prasad A, Maurya P, Chandra P (2016) Nanobiosensors: next generation point-of-care biomedical devices for personalized diagnosis. J Anal Bioanal Tech 7:e125
Majdinasab M, Badea M, Marty JL (2022) Aptamer-based lateral flow assays: current trends in clinical diagnostic rapid tests. Pharmaceuticals 15(1):90. https://doi.org/10.3390/ph15010090
McNichols RJ, Coté GL (2000) Optical glucose sensing in biological fluids: an overview. J Biomed Opt 5(1):5–16. https://doi.org/10.1117/1.429962
Miočević O, Cole CR, Laughlin MJ, Buck RL, Slowey PD, Shirtcliff EA (2017) Quantitative lateral flow assays for salivary biomarker assessment: a review. Front Public Health 5:5
Mühlig A, Bocklitz T, Labugger I, Dees S, Henk S, Richter E, Andres S, Merker M, Stöckel S, Weber K, Cialla-May D, Popp J (2016) LOC-SERS: a promising closed system for the identification of mycobacteria. Anal Chem 88(16):7998–8004. https://doi.org/10.1021/acs.analchem.6b01152
Nair LV, Philips DS, Jayasree RS, Ajayaghosh A (2013a) A near-infrared fluorescent nanosensor (AuC@urease) for the selective detection of blood urea. Small 9(16):2673–2677. https://doi.org/10.1002/smll.201300213
Nair LV, Philips DS, Jayasree RS, Ajayaghosh A (2013b) A near-infrared fluorescent nanosensor (AuC@Urease) for the selective detection of blood urea. Small 9(16):2673–2677. https://doi.org/10.1002/smll.201300213
Nair RV, Suma PRP, Jayasree RS (2020) A dual signal on-off fluorescent nanosensor for the simultaneous detection of copper and creatinine. Mater Sci Eng C 109:110569. https://doi.org/10.1016/j.msec.2019.110569
Nurul Najian AB, Syafirah EN, Ismail N, Mohamed M, Yean CY (2016) Development of multiplex loop mediated isothermal amplification (m-LAMP) label-Based gold nanoparticles lateral flow dipstick biosensor for detection of pathogenic leptospira. Anal Chim Acta 903:142–148. https://doi.org/10.1016/j.aca.2015.11.015
Paper-Based Plasmonic Platform for Sensitive (2014) Noninvasive, and rapid cancer screening. Biosens Bioelectron 54:128–134. https://doi.org/10.1016/j.bios.2013.10.067
Park E-Y, Baik J, Kim H, Park S-M, Kim C (2020) Ultrasound-modulated optical Glucose sensing using a 1645 nm laser. Sci Rep 10(1):13361. https://doi.org/10.1038/s41598-020-70305-6
Park TJ, Lee SJ, Kim D-K, Heo NS, Park JY, Lee SY (2012) Development of label-free optical diagnosis for sensitive detection of influenza virus with genetically engineered fusion protein. Talanta 89:246–252. https://doi.org/10.1016/j.talanta.2011.12.021
Peng H, Chen IA (2019) Rapid colorimetric detection of bacterial species through the capture of gold nanoparticles by chimeric phages. ACS Nano 13(2):1244–1252. https://doi.org/10.1021/acsnano.8b06395
Perrone RD, Madias NE, Levey AS (1992) Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 38(10):1933–1953
Purohit B, Divya, Shetti NP, Chandra P (2022b) Chapter 2 - Materials for wearable sensors. In: Morales-Narvaez E, Dincer C (eds) Wearable physical, chemical and biological sensors. Elsevier, Amsterdam, pp 5–40. https://doi.org/10.1016/B978-0-12-821661-3.00012-4
Purohit B, Kumar A, Mahato K, Chandra P (2022a) Continuous glucose monitoring for diabetes management based on miniaturized biosensors. In: Chandra P, Mahato K (eds) Miniaturized biosensing devices: fabrication and applications. Springer Nature, Singapore, pp 149–175. https://doi.org/10.1007/978-981-16-9897-2_7
Qin D, He X, Wang K, Zhao XJ, Tan W, Chen J (2007) Fluorescent nanoparticle-based indirect immunofluorescence microscopy for detection of Mycobacterium tuberculosis. J Biomed Biotechnol 2007:e89364. https://doi.org/10.1155/2007/89364
Quesada-González D, Merkoçi A (2018) Nanomaterial-based devices for point-of-care diagnostic applications. Chem Soc Rev 47(13):4697–4709. https://doi.org/10.1039/C7CS00837F
Rouleau L, Berti R, Ng VWK, Matteau-Pelletier C, Lam T, Saboural P, Kakkar AK, Lesage F, Rhéaume E, Tardif J-C (2013) VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice. Contrast Media Mol Imaging 8(1):27–39. https://doi.org/10.1002/cmmi.1491
Sharma S, Shrivastav AM, Gupta BD (2020) Lossy mode resonance Based fiber optic creatinine sensor fabricated using molecular imprinting over nanocomposite of MoS2/SnO2. IEEE Sensors J 20(8):4251–4259. https://doi.org/10.1109/JSEN.2020.2964262
Sierra AF, Hernández-Alonso D, Romero MA, González-Delgado JA, Pischel U, Ballester P (2020) Optical supramolecular sensing of creatinine. J Am Chem Soc 142:4276. https://doi.org/10.1021/jacs.9b12071
Sivakumar R, Phong Dinh V, Yoon Lee N (2021) Ultraviolet-induced in situ gold nanoparticles for point-of-care testing of infectious diseases in loop-mediated isothermal amplification. Lab Chip 21(4):700–709. https://doi.org/10.1039/D1LC00019E
Soundharraj P, Dhinasekaran D, Rajendran AR, Prakasarao A, Ganesan S (2021) N-doped zinc oxide as an effective fluorescence sensor for urea detection. New J Chem 45(13):6080–6090. https://doi.org/10.1039/D1NJ00372K
Stanisavljevic M, Krizkova S, Vaculovicova M, Kizek R, Adam V (2015) Quantum dots-fluorescence resonance energy transfer-based nanosensors and their application. Biosens Bioelectron 74:562–574. https://doi.org/10.1016/j.bios.2015.06.076
Stiles PL, Dieringer JA, Shah NC, Van Duyne RP (2008) Surface-enhanced Raman spectroscopy. Annu Rev Anal Chem (Palo Alto, Calif) 1:601–626. https://doi.org/10.1146/annurev.anchem.1.031207.112814
Sun J, Xianyu Y, Jiang X (2014) Point-of-care biochemical assays using gold nanoparticle-implemented microfluidics. Chem Soc Rev 43(17):6239–6253. https://doi.org/10.1039/c4cs00125g
Syahir A, Usui K, Tomizaki K, Kajikawa K, Mihara H (2015) Label and label-free detection techniques for protein microarrays. Microarrays (Basel) 4(2):228–244. https://doi.org/10.3390/microarrays4020228
Takemura K, Adegoke O, Takahashi N, Kato T, Li T-C, Kitamoto N, Tanaka T, Suzuki T, Park EY (2017) Versatility of a localized surface plasmon resonance-based gold nanoparticle-alloyed quantum dot nanobiosensor for immunofluorescence detection of viruses. Biosens Bioelectron 89:998–1005. https://doi.org/10.1016/j.bios.2016.10.045
Ventura BD, Cennamo M, Minopoli A, Campanile R, Censi SB, Terracciano D, Portella G, Velotta R (2020) Colorimetric test for fast detection of SARS-CoV-2 in nasal and throat swabs. ACS Sens 5(10):3043–3048. https://doi.org/10.1021/acssensors.0c01742
Vikas, Gupta S, Tejavath K, Verma RK (2020) Urea detection using bio-synthesized gold nanoparticles: an SPR/LSPR based sensing approach realized on optical fiber. Opt Quant Electron 52(6):278. https://doi.org/10.1007/s11082-020-02405-6
Vilela P, El-Sagheer A, Millar TM, Brown T, Muskens OL, Kanaras AG (2017) Graphene oxide-upconversion nanoparticle based optical Sensors for targeted detection of MRNA biomarkers present in Alzheimer’s disease and prostate cancer. ACS Sens 2(1):52–56. https://doi.org/10.1021/acssensors.6b00651
Wang C, Yang X, Gu B, Liu H, Zhou Z, Shi L, Cheng X, Wang S (2020) Sensitive and simultaneous detection of SARS-CoV-2-specific IgM/IgG using lateral flow immunoassay based on dual-mode quantum dot nanobeads. Anal Chem 92(23):15542–15549. https://doi.org/10.1021/acs.analchem.0c03484
Wang J-H, Wang B, Liu Q, Li Q, Huang H, Song L, Sun T-Y, Wang H, Yu X-F, Li C, Chu PK (2013) Bimodal optical diagnostics of Oral cancer based on rose Bengal conjugated gold nanorod platform. Biomaterials 34(17):4274–4283. https://doi.org/10.1016/j.biomaterials.2013.02.012
Wang Y, Li H, Wang Y, Li H, Luo L, Xu J, Ye C (2017c) Development of multiple cross displacement amplification label-based gold nanoparticles lateral flow biosensor for detection of listeria monocytogenes. Int J Nanomedicine 12:473–486. https://doi.org/10.2147/IJN.S123625
Wang Y, Li H, Wang Y, Zhang L, Xu J, Ye C (2017b) Loop-mediated isothermal amplification label-based gold nanoparticles lateral flow biosensor for detection of enterococcus faecalis and staphylococcus aureus. Front Microbiol 8:192. https://doi.org/10.3389/fmicb.2017.00192
Wang Y, Osborne MT, Tung B, Li M, Li Y (2018) Imaging cardiovascular calcification. J Am Heart Assoc 7(13):e008564. https://doi.org/10.1161/JAHA.118.008564
Wang Y, Wang Y, Xu J, Ye C (1834) Development of multiple cross displacement amplification label-based gold nanoparticles lateral flow biosensor for detection of Shigella Spp. Front Microbiol 2016:7. https://doi.org/10.3389/fmicb.2016.01834
Wang Y, Yu L, Kong X, Sun L (2017a) Application of nanodiagnostics in point-of-care tests for infectious diseases. Int J Nanomedicine 12:4789–4803. https://doi.org/10.2147/IJN.S137338
Wang Y-F, Pang D-W, Zhang Z-L, Zheng H-Z, Cao J-P, Shen J-T (2003) Visual gene diagnosis of HBV and HCV based on nanoparticle probe amplification and silver staining enhancement. J Med Virol 70(2):205–211. https://doi.org/10.1002/jmv.10379
Xia Y, Zhu C, Bian J, Li Y, Liu X, Liu Y (2019) Highly sensitive and selective colorimetric detection of creatinine based on synergistic effect of PEG/Hg2+–AuNPs. Nanomaterials (Basel) 9(10):1424. https://doi.org/10.3390/nano9101424
Xiong L-H, Cui R, Zhang Z-L, Yu X, Xie Z, Shi Y-B, Pang D-W (2014) Uniform fluorescent nanobioprobes for pathogen detection. ACS Nano 8(5):5116–5124. https://doi.org/10.1021/nn501174g
Xu H, Chen J, Birrenkott J, Zhao JX, Takalkar S, Baryeh K, Liu G (2014) Gold-nanoparticle-decorated silica nanorods for sensitive visual detection of proteins. Anal Chem 86(15):7351–7359. https://doi.org/10.1021/ac502249f
Yang H, Li D, He R, Guo Q, Wang K, Zhang X, Huang P, Cui D (2010) A novel quantum dots–based point of care test for syphilis. Nanoscale Res Lett 5(5):875–881. https://doi.org/10.1007/s11671-010-9578-1
Yanik AA, Huang M, Kamohara O, Artar A, Geisbert TW, Connor JH, Altug H (2010) An optofluidic nanoplasmonic biosensor for direct detection of live viruses from Biological media. Nano Lett 10(12):4962–4969. https://doi.org/10.1021/nl103025u
Yelbuz TM, Choma MA, Thrane L, Kirby ML, Izatt JA (2002) Optical coherence tomography: a new high-resolution imaging technology to study cardiac development in chick embryos. Circulation 106(22):2771–2774. https://doi.org/10.1161/01.cir.0000042672.51054.7b
Yen C-W, de Puig H, Tam JO, Gómez-Márquez J, Bosch I, Hamad-Schifferli K, Gehrke L (2015) Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses. Lab Chip 15(7):1638–1641. https://doi.org/10.1039/C5LC00055F
Yin W, Yin W, Yin W, Zhang Y, Zhang Y, Gu J, Gu J, Wang T, Wang T, Ma C, Ma C, Zhu C, Zhu C, Li L, Li L, Yang Z, Yang Z, Yang Z, Zhu T, Zhu T, Chen G, Chen G (2021) Urea detection in milk by urease-assisted PH-sensitive carbon dots. Appl Opt 60(33):10421–10428. https://doi.org/10.1364/AO.437787
Yu M, Wang H, Fu F, Li L, Li J, Li G, Song Y, Swihart MT, Song E (2017) Dual-recognition Förster resonance energy transfer based platform for one-step sensitive detection of pathogenic bacteria using fluorescent vancomycin–gold nanoclusters and aptamer–gold nanoparticles. Anal Chem 89(7):4085–4090. https://doi.org/10.1021/acs.analchem.6b04958
Zakaria NI, Mohammad R, Hanifah SA, Ahmad A (2022) Cockle shell-derived nanoparticles for optical urea biosensor development based on reflectance transduction. Arab J Chem 15(3):103647. https://doi.org/10.1016/j.arabjc.2021.103647
Zhang J, Tian J, He Y, Chen S, Jiang Y, Zhao Y, Zhao S (2013) Protein -binding aptamer assisted signal amplification for the detection of influenza A (H1N1) DNA sequences based on quantum dot fluorescence polarization analysis. Analyst 138(17):4722–4727. https://doi.org/10.1039/C3AN00830D
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Joseph, M., Rahman, P.P.M.S., Nair, L.V. (2023). Optically Active Nanomaterials for Point-of-Care Diagnosis in Healthcare. In: Purohit, B., Chandra, P. (eds) Surface Engineering and Functional Nanomaterials for Point-of-Care Analytical Devices. Springer, Singapore. https://doi.org/10.1007/978-981-99-3025-8_5
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