Abstract
Genome editing is the precise manipulation of genetic material in a living organism by deleting, replacing, or inserting a DNA sequence to alter the cell’s fate or organism’s traits. It typically aims to improve a crop or farm animal or to correct a genetic disorder. Genome editing involves creating a double-strand break (DSB) using specific nuclease systems, joining the DNA ends precisely through a homologous repair mechanism or a nonhomologous end joining (NHEJ). The advancement in biotechnological tools and newer genome editing platforms has paved the way for more precise and efficient alterations into genomes. Apart from introducing genetic modifications for desirable traits in animals, gene editing tools have also been implied in the development of diagnostic, prevention (vaccine development through genome editing in infectious pathogens), and therapeutic modalities for improving animal health. The present chapter elaborates on the applications of modern biotechnology tools of “genome editing” in preserving animal health through various means like selective breeding, development diagnostics, therapeutics, and other disease prevention modalities like effective vaccines.
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Mathapati, B., Singh, V.K. (2023). Genome Editing: Applications in Animal Health. In: Mukhopadhyay, C.S., Choudhary, R.K., Panwar, H., Malik, Y.S. (eds) Biotechnological Interventions Augmenting Livestock Health and Production. Livestock Diseases and Management. Springer, Singapore. https://doi.org/10.1007/978-981-99-2209-3_1
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DOI: https://doi.org/10.1007/978-981-99-2209-3_1
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