Abstract
Breast cancer mortality is fleeting in females worldwide. Numerous genetic, epigenetic, and environmental factors contribute to breast cancer progression. It is a conditional hormone disease that depends mainly on estrogen regulation. A higher percentage of breast cancer patients are estrogen receptor positive. Estrogen-related receptors are a group of orphan nuclear receptors that share a high level of homology with ERα. The ERR family comprises ERRα, ERRβ, and ERRϒ. Among them, ERRα and ERRϒ have essential roles as transcriptional activators and repressors in cancer and metabolism, respectively.
Estrogen-related receptor beta (ERRβ) is negatively regulated in breast cancer cells, and overexpression of this receptor in breast cancer patients is associated with a longer chance of remission and a better prognosis. Our study highlights the significance of the orphan molecule, ERRβ, and its multiple signaling events in breast cancer progression. So, targeting ERRβ could provide a significant breakthrough in the breast cancer research.
This is a preview of subscription content, log in via an institution to check access.
References
Ariazi EA, Clark GM, Mertz JE (2002) Estrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res 62(22):6510–6518
Bombail V, Collins F, Brown P, Saunders PT (2010) Modulation of ERα transcriptional activity by the orphan nuclear receptor ERRβ and evidence for differential effects of long-and short-form splice variants. Mol Cell Endocrinol 314(1):53–61. https://doi.org/10.1016/j.mce.2009.09.007
Chen X, Cui D, Bi Y, Shu J, Xiong X, Zhao Y (2018) AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. Cell Cycle 17(16):2069–2079
Horard B, Vanacker JM (2003) Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand. J Mol Endocrinol 31(3):349–357. https://doi.org/10.1677/jme.0.0310349
Horard B, Castet A, Bardet PL, Laudet V, Cavaillès V, Vanacker JM (2004) Dimerization is required for transactivation by estrogen-receptor-related (ERR) orphan receptors: evidence from amphioxus ERR. J Mol Endocrinol 33(2):493–509. https://doi.org/10.1677/jme.1.01538
Lu D, Kiriyama Y, Lee KY, Giguere V (2001) Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors. Cancer Res 61(18):6755–6761
Madhu Krishna B, Chaudhary S, Mishra DR, Naik SK, Suklabaidya S, Adhya AK, Mishra SK (2018) Estrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer. BMC Cancer 18(1):1–5. https://doi.org/10.1186/s12885-018-4528-x
Naik SK, Lam EW, Parija M, Prakash S, Jiramongkol Y, Adhya AK, Parida DK, Mishra SK (2020) NEDDylation negatively regulates ERRβ expression to promote breast cancer tumorigenesis and progression. Cell Death Dis 11(8):1–6. https://doi.org/10.1038/s41419-020-02838-7
Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M, Gustafsson JÅ (2001) Mechanisms of estrogen action. Physiol Rev 81(4):1535–1565. https://doi.org/10.1152/physrev.2001.81.4.1535
Sengupta D, Bhargava DK, Dixit A, Sahoo BS, Biswas S, Biswas G, Mishra SK (2014) ERRβ signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells. Br J Cancer 110(8):2144–2158. https://doi.org/10.1038/bjc.2014.53
Thomas C, Gustafsson JÅ (2011) The different roles of ER subtypes in cancer biology and therapy. Nat Rev Cancer 11(8):597–608. https://doi.org/10.1038/nrc3093
Yang D, Tan M, Wang G, Sun Y (2012) The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. PLoS One 7(3):e34079. https://doi.org/10.1371/journal.pone.0034079
Yu S, Wong YC, Wang XH, Ling MT, Ng CF, Chen S, Chan FL (2008) Orphan nuclear receptor estrogen-related receptor-β suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer. Oncogene 27(23):3313–3328. https://doi.org/10.1038/sj.onc.1210986
Zhu T, Wang J, Pei Y, Wang Q, Wu Y, Qiu G, Zhang D, Lv M, Li W, Zhang J (2016) Neddylation controls basal MKK7 kinase activity in breast cancer cells. Oncogene 35(20):2624–2633. https://doi.org/10.1038/onc.2015.323
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2023 Springer Nature Singapore Pte Ltd.
About this entry
Cite this entry
Mishra, S.K., Parija, M., Prakash, S. (2023). Therapeutic Efficacy of Estrogen-Related Receptor β in Breast Carcinoma. In: Sobti, R.C., Ganguly, N.K., Kumar, R. (eds) Handbook of Oncobiology: From Basic to Clinical Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-99-2196-6_18-1
Download citation
DOI: https://doi.org/10.1007/978-981-99-2196-6_18-1
Received:
Accepted:
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-2196-6
Online ISBN: 978-981-99-2196-6
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences