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Nanomedicine for Cardiac Diseases

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Nanomedicine

Part of the book series: SpringerBriefs in Applied Sciences and Technology ((BRIEFSNANO))

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Abstract

Nanomedicine is a rapidly developing field with the potential to transform the treatment of cardiac diseases. It entails the use of nanoscale materials and devices to diagnose, treat, and prevent a variety of cardiovascular diseases. The development of nanocarriers for drug delivery is a key application of nanomedicine in cardiology. This chapter delineates the applications of nanomedicine in diagnostics and treatment of cardiovascular diseases.

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References

  • Bertrand N, Bouvet C, Moreau P, Leroux J-C (2010) Transmembrane pH-gradient liposomes to treat cardiovascular drug intoxication. ACS Nano 4(12):7552–7558

    Article  Google Scholar 

  • Cheng K, Shen D, Hensley MT, Middleton R, Sun B, Liu W, De Couto G, Marbán E (2014) Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting. Nat Commun 5:4880

    Article  ADS  Google Scholar 

  • Chopra H, Bibi S, Mishra AK, Tirth V, Yerramsetty SV, Murali SV, Ahmad SU, Mohanta YK, Attia MS, Algahtani A (2022) Nanomaterials: a promising therapeutic approach for cardiovascular diseases. J Nanomater 2022:1–25

    Google Scholar 

  • Di Mauro V, Iafisco M, Salvarani N, Vacchiano M, Carullo P, Ramírez-Rodríguez GB, Patrício T, Tampieri A, Miragoli M, Catalucci D (2016) Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs. Nanomedicine 11(8):891–906

    Article  Google Scholar 

  • El Shaer SS, Salaheldin TA, Saied NM, Abdelazim SM (2017) In vivo ameliorative effect of cerium oxide nanoparticles in isoproterenol-induced cardiac toxicity. Exp Toxicol Pathol 69(7):435–441

    Article  Google Scholar 

  • Ferreira MP, Ranjan S, Kinnunen S, Correia A, Talman V, Mäkilä E, Barrios-Lopez B, Kemell M, Balasubramanian V, Salonen J (2017) Drug-loaded multifunctional nanoparticles targeted to the endocardial layer of the injured heart modulate hypertrophic signaling. Small 13(33):1701276

    Article  Google Scholar 

  • Ferreira PA, M., V. Balasubramanian, J. Hirvonen, H. Ruskoaho and H. A Santos, (2015) Advanced nanomedicines for the treatment and diagnosis of myocardial infarction and heart failure. Curr Drug Targets 16(14):1682–1697

    Article  Google Scholar 

  • Ferreira MP, Talman V, Torrieri G, Liu D, Marques G, Moslova K, Liu Z, Pinto JF, Hirvonen J, Ruskoaho H (2018) Dual-drug delivery using dextran-functionalized nanoparticles targeting cardiac fibroblasts for cellular reprogramming. Adv Funct Mater 28(15):1705134

    Article  Google Scholar 

  • Galagudza M, Korolev D, Postnov V, Naumisheva E, Grigorova Y, Uskov I, Shlyakhto E (2012) Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles. Int J Nanomed 1671–1678

    Google Scholar 

  • Giannouli M, Karagkiozaki V, Pappa F, Moutsios I, Gravalidis C, Logothetidis S (2018) Fabrication of quercetin-loaded PLGA nanoparticles via electrohydrodynamic atomization for cardiovascular disease. Mater Today Proc 5(8):15998–16005

    Article  Google Scholar 

  • Godin B, Sakamoto JH, Serda RE, Grattoni A, Bouamrani A, Ferrari M (2010) Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases. Trends Pharmacol Sci 31(5):199–205

    Article  Google Scholar 

  • Guo Y, Chen W, Wang W, Shen J, Guo R, Gong F, Lin S, Cheng D, Chen G, Shuai X (2012) Simultaneous diagnosis and gene therapy of immuno-rejection in rat allogeneic heart transplantation model using a T-cell-targeted theranostic nanosystem. ACS Nano 6(12):10646–10657

    Article  Google Scholar 

  • Haeck ML, Hoogslag GE, Rodrigo SF, Atsma DE, Klautz R, van der Wall EE, Schalij MJ, Verwey HF (2012) Treatment options in end-stage heart failure: where to go from here? Neth Heart J 20:167–175

    Article  Google Scholar 

  • Hasan A, Waters R, Roula B, Dana R, Yara S, Alexandre T, Paul A (2016) Engineered biomaterials to enhance stem cell-based cardiac tissue engineering and therapy. Macromol Biosci 16(7):958–977

    Article  Google Scholar 

  • Kleinstreuer C, Chari SV, Vachhani S (2018) Potential use of multifunctional nanoparticles for the treatment of cardiovascular diseases. J Cardiol Cardiovasc Sci 2(3)

    Google Scholar 

  • Li W, Liu Z, Fontana F, Ding Y, Liu D, Hirvonen JT, Santos HA (2018) Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy. Adv Mater 30(24):1703740

    Article  Google Scholar 

  • Lin Y-D, Ko M-C, Wu S-T, Li S-F, Hu J-F, Lai Y-J, Hans I, Harn C, Laio I-C, Yeh M-L (2014) A nanopatterned cell-seeded cardiac patch prevents electro-uncoupling and improves the therapeutic efficacy of cardiac repair. Biomater Sci 2(4):567–580

    Article  Google Scholar 

  • Liu S, Chen X, Bao L, Liu T, Yuan P, Yang X, Qiu X, Gooding JJ, Bai Y, Xiao J (2020) Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles. Nat Biomed Eng 4(11):1063–1075

    Article  Google Scholar 

  • Martinelli V, Cellot G, Fabbro A, Bosi S, Mestroni L, Ballerini L (2013) Improving cardiac myocytes performance by carbon nanotubes platforms. Front Physiol 4:239

    Article  Google Scholar 

  • Mohamed NA, Marei I, Crovella S, Abou-Saleh H (2022) Recent developments in nanomaterials-based drug delivery and upgrading treatment of cardiovascular diseases. Int J Mol Sci 23(3):1404

    Article  Google Scholar 

  • Ouyang J, Xie A, Zhou J, Liu R, Wang L, Liu H, Kong N, Tao W (2022) Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging. Chem Soc Rev 51(12):4996–5041

    Article  Google Scholar 

  • Paul A, Hasan A, Kindi HA, Gaharwar AK, Rao VT, Nikkhah M, Shin SR, Krafft D, Dokmeci MR, Shum-Tim D (2014) Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair. ACS Nano 8(8):8050–8062

    Article  Google Scholar 

  • Ruiz-Esparza GU, Segura-Ibarra V, Cordero-Reyes AM, Youker KA, Serda RE, Cruz-Solbes AS, Amione-Guerra J, Yokoi K, Kirui DK, Cara FE (2016) A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics. Eur J Heart Fail 18(2):169–178

    Article  Google Scholar 

  • Saeed S, Khan SU, Gul R (2023) Nanoparticle: a promising player in nanomedicine and its theranostic applications for the treatment of cardiovascular diseases. Curr Probl Cardiol 101599

    Google Scholar 

  • Serpooshan V, Sivanesan S, Huang X, Mahmoudi M, Malkovskiy AV, Zhao M, Inayathullah M, Wagh D, Zhang XJ, Metzler S (2015) [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials 37:289–298

    Article  Google Scholar 

  • Shin SR, Jung SM, Zalabany M, Kim K, Zorlutuna P, Kim SB, Nikkhah M, Khabiry M, Azize M, Kong J (2013) Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators. ACS Nano 7(3):2369–2380

    Article  Google Scholar 

  • Sobolewski P, El Fray M (2015) Cardiac catheterization: consequences for the endothelium and potential for nanomedicine. Wiley Interdisc Rev Nanomed Nanobiotechnol 7(3):458–473

    Article  Google Scholar 

  • Tariq U, Gupta M, Pathak S, Patil R, Dohare A, Misra SK (2022) Role of biomaterials in cardiac repair and regeneration: therapeutic intervention for myocardial infarction. ACS Biomater Sci Eng 8(8):3271–3298

    Article  Google Scholar 

  • Terrasini N, Lionetti V (2017) Exosomes in critical illness. Crit Care Med 45(6):1054–1060

    Article  Google Scholar 

  • Tieu T, Alba M, Elnathan R, Cifuentes-Rius A, Voelcker NH (2019) Advances in porous silicon–based nanomaterials for diagnostic and therapeutic applications. Adv Ther 2(1):1800095

    Article  Google Scholar 

  • Toffoli G, Hadla M, Corona G, Caligiuri I, Palazzolo S, Semeraro S, Gamini A, Canzonieri V, Rizzolio F (2015) Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin. Nanomedicine 10(19):2963–2971

    Article  Google Scholar 

  • Tölli MA, Ferreira MP, Kinnunen SM, Rysä J, Mäkilä EM, Szabó Z, Serpi RE, Ohukainen PJ, Välimäki MJ, Correia AM (2014) In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart. Biomaterials 35(29):8394–8405

    Article  Google Scholar 

  • Yang J, Wang P, Jiang X, Xu J, Zhang M, Liu F, Lin Y, Tao J, He J, Zhou X, Zhang M (2023) A nanotherapy of octanoic acid ameliorates cardiac arrest/cardiopulmonary resuscitation-induced brain injury via RVG29- and neutrophil membrane-mediated injury relay targeting. ACS Nano

    Google Scholar 

  • Yao M, Ma M, Zhang H, Zhang Y, Wan G, Shen J, Chen H, Wu R (2018) Mesopore-induced aggregation of cobalt protoporphyrin for photoacoustic imaging and antioxidant protection of stem cells. Adv Funct Mater 28(47):1804497

    Article  Google Scholar 

  • Zanjanizadeh Ezazi N, Ajdary R, Correia A, Mäkilä E, Salonen J, Kemell M, Hirvonen J, Rojas OJ, Ruskoaho HJ, H. l. A. Santos, (2020) Fabrication and characterization of drug-loaded conductive poly (glycerol sebacate)/nanoparticle-based composite patch for myocardial infarction applications. ACS Appl Mater Interfaces 12(6):6899–6909

    Article  Google Scholar 

  • Zhang D-X, Yoshikawa C, Welch NG, Pasic P, Thissen H, Voelcker NH (2019) Spatially controlled surface modification of porous silicon for sustained drug delivery applications. Sci Rep 9(1):1367

    Article  ADS  Google Scholar 

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Authors and Affiliations

  1. Alpha Biomedical Pte. Ltd., Singapore, Singapore

    Tamil Selvan Subramanian

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  1. Tamil Selvan Subramanian
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Correspondence to Tamil Selvan Subramanian .

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Subramanian, T.S. (2023). Nanomedicine for Cardiac Diseases. In: Nanomedicine. SpringerBriefs in Applied Sciences and Technology(). Springer, Singapore. https://doi.org/10.1007/978-981-99-2139-3_5

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