Functionalized Dendrimers: Promising Nanocarriers for Theranostic Applications

Pathak, Anchal; Naqvi, Saba; Jain, Keerti

doi:10.1007/978-981-99-0538-6_8

Anchal Pathak³,
Saba Naqvi⁴ &
Keerti Jain³

139 Accesses

Abstract

“Nanotheranostic” is an integrative approach to achieve diagnosis and therapeutic effect simultaneously, using nanocarriers. Nanotheranostic platform can be engineered to overcome biological barriers, to target the therapeutic agent at the required locus, and to support the monitoring of drug delivery. Dendrimers are well-defined 3D globular nanoarchitectured monodisperse system, pliable to precise size control and surface modification, which could serve as a potential nanotheranostic platform to achieve image-guided therapy, distribution monitoring, and drug targeting. Dendrimers exhibit biodegradable, biocompatible, and stimuli-responsive features that could ensure the anticipated biodistribution and efficacy. In this chapter, the utility of dendrimer as a theranostic nanoplatform embodying diversified category of therapeutic, imaging, and targeting moieties has been explored. Dendrimer-based administration of imaging agents (magnetic resonance imaging, computed tomography, single-photon emission computed tomography) along with its application in chemotherapy, pharmacodynamics therapy, and gene therapy has also been discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 149.00; Price excludes VAT (USA)

Hardcover Book: USD 199.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

AuDENPs:: Dendrimer-entrapped gold nanoparticles
CNTs:: Carbon nanotubes
CT:: Computed tomography
DANPs:: Dendrimer-assembled nanoparticles
DENPs:: Dendrimer-entrapped nanoparticles
DIONPs:: Dendrimer-based iron oxide nanoparticles
DOTA:: 1,4,7,10-Tetraazacyclododecane-N,N′,N′′,N′′′-tetra-acetic acids
DOX:: Doxorubicin
DSNPs:: Dendrimer-stabilized nanoparticles
DTPA:: Asdi-ethylenetriamine-penta-acetic acid
EPR:: Enhanced permeation and retention effect
FA:: Folic Acid
FMT:: Fluorescence molecular tomography
FOI:: Fluorescence optical imaging
IONPs:: Iron oxide nanoparticles
LHRH:: Luteinizing hormone-releasing hormone
MDR:: Multidrug resistance
MRI:: Magnetic resonance imaging
NIR:: Near-infrared radiation
NPs:: Nanoparticles
NRs:: Nanorods
PAMAM:: Polyamidoamine dendrimer
Pc:: Phthalocyanine
PDT:: Photodynamic therapy
PEG:: Polyethylene glycol
PET:: Positron emission tomography
PLL:: Poly-L-lysine
PPI:: Polypropylenimine dendrimer
PTT:: Photothermal therapy
RGD:: Arg-Gly-Asp
SiNc:: Silicon naphthalocyanine
SPECT:: Single-photon emission computed tomography
SPIONs:: Superparamagnetic iron nanoparticles
TOS:: α-Tocopheryl succinate
TPGS:: D-α-tocopherol polyethylene glycol 1000 succinate

References

Ahmad J, Albarqi HA, Ahmad MZ, Md R, Suthar T, Jain K, Vuddanda PR, Khan MA (2022) Receptor-targeted surface-engineered nanomaterials for breast cancer imaging and Theranostic applications. Crit Rev Ther Drug Carrier Syst 39:1–44. https://doi.org/10.1615/CRITREVTHERDRUGCARRIERSYST.2022040686
Article PubMed Google Scholar
Alibolandi M, Hoseini F, Mohammadi M, Ramezani P, Einafshar E, Taghdisi SM, Ramezani M, Abnous K (2018) Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma. Int J Pharm 549:67–75. https://doi.org/10.1016/j.ijpharm.2018.07.052
Article CAS PubMed Google Scholar
Bagre A, Patel PR, Naqvi S, Jain K (2022) Emerging concerns of infectious diseases and drug delivery challenges. In: Nanotheranostics for treatment and diagnosis of infectious diseases, pp 1–23. https://doi.org/10.1016/B978-0-323-91201-3.00013-X
Google Scholar
Bhavana V, Pradip T, Jain K, Mehra NK (2021) Dendrimer–guest interaction chemistry and mechanism. Dendrimers in Nanomedicine:171–185. https://doi.org/10.1201/9781003029915-9
Chang Y, Li Y, Meng X, Liu N, Sun D, Liu H, Wang J (2013) Dendrimer functionalized water soluble magnetic iron oxide conjugates as dual imaging probe for tumor targeting and drug delivery. Polym Chem 4:789–794. https://doi.org/10.1039/c2py20740k
Article CAS Google Scholar
Dasgupta A, Biancacci I, Kiessling F, Lammers T (2020) Imaging-assisted anticancer nanotherapy. Theranostics 10:956–967. https://doi.org/10.7150/thno.38288
Article CAS PubMed PubMed Central Google Scholar
Dendrimer-Based Nanotherapeutics (2021) https://doi.org/10.1016/c2019-0-03208-6
Fan Y, Zhang J, Shi M, Li D, Lu C, Cao X, Peng C, Mignani S, Majoral JP, Shi X (2019) Poly(amidoamine) dendrimer-coordinated copper(II) complexes as a theranostic nanoplatform for the radiotherapy-enhanced magnetic resonance imaging and chemotherapy of tumors and tumor metastasis. Nano Lett 19:1216–1226. https://doi.org/10.1021/acs.nanolett.8b04757
Article CAS PubMed Google Scholar
Felder-Flesch D (2021) Dendrimers as nanomedicine in cancer therapy, in: Dendrimers in nanomedicine, pp. 309–326. https://doi.org/10.1201/9781315364513-13
Funkhouser J (2002) Reinventing pharma: the theranostic revolution. Curr Drug Discov:17–19
Google Scholar
Gauro R, Jain K, Jain VK, Mehra NK, Popli H (2021a) Macromolecular architecture and molecular modelling of dendrimers. Dendrimers Nanomed:77–88. https://doi.org/10.1201/9781003029915-5
Gauro R, Nandave M, Jain VK, Jain K (2021b) Advances in dendrimer-mediated targeted drug delivery to the brain. J Nanopart Res 23. https://doi.org/10.1007/s11051-021-05175-8
Ge R, Cao J, Chi J, Han S, Liang Y, Xu L, Liang M, Sun Y (2019) NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy. Int J Nanomedicine 14:4931–4947. https://doi.org/10.2147/IJN.S203171
Article CAS PubMed PubMed Central Google Scholar
Huang R, Han L, Li J, Liu S, Shao K, Kuang Y, Hu X, Wang X, Lei H, Jiang C (2011) Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis. Biomaterials 32:5177–5186. https://doi.org/10.1016/j.biomaterials.2011.03.075
Article CAS PubMed Google Scholar
Hyun H, Cho CS (2019) Updates in molecular imaging techniques. Tissue Eng Regen Med 16:431–432. https://doi.org/10.1007/s13770-019-00222-x
Article CAS PubMed PubMed Central Google Scholar
Israel O, Pellet O, Biassoni L, De Palma D, Estrada-Lobato E, Gnanasegaran G, Kuwert T, la Fougère C, Mariani G, Massalha S, Paez D, Giammarile F (2019) Two decades of SPECT/CT—the coming of age of a technology: an updated review of literature evidence. Eur J Nucl Med Mol Imaging 46:1990–2012. https://doi.org/10.1007/s00259-019-04404-6
Article PubMed PubMed Central Google Scholar
Jain A, Jain K, Mehra NK, Jain NK (2013) Lipoproteins tethered dendrimeric nanoconstructs for effective targeting to cancer cells. J Nanopart Res 15. https://doi.org/10.1007/s11051-013-2003-9
Jain K (2017) Dendrimers: smart nanoengineered polymers for bioinspired applications in drug delivery. Biopolym Compos Drug Deliv Biomed Appl:169–220. https://doi.org/10.1016/B978-0-08-101914-6.00007-7
Jain K (2018) Dendrimers: emerging anti-infective nanomedicines. NanoBioMaterials:121–138. https://doi.org/10.1201/9781351138666-6
Jain K, Ahmad J (2022) Nanotheranostics for treatment and diagnosis of infectious diseases, pp 1–391. https://doi.org/10.1016/C2020-0-03819-3
Google Scholar
Jain K, Gupta U, Jain NK (2014) Dendronized nanoconjugates of lysine and folate for treatment of cancer. Eur J Pharm Biopharm 87:500–509. https://doi.org/10.1016/j.ejpb.2014.03.015
Article CAS PubMed Google Scholar
Jain K, Jain NK (2014) Surface engineered dendrimers as antiangiogenic agent and carrier for anticancer drug: dual attack on cancer. J Nanosci Nanotechnol 14:5075–5087. https://doi.org/10.1166/jnn.2014.8677
Article CAS PubMed Google Scholar
Jain K, Kesharwani P, Gupta U, Jain NK (2010) Dendrimer toxicity: let’s meet the challenge. Int J Pharm 394:122–142. https://doi.org/10.1016/j.ijpharm.2010.04.027
Article CAS PubMed Google Scholar
Jain K, Mehra NK, Jain VK, Jain NK (2020) IPN dendrimers in drug delivery. Interpenetr Polym Netw Biomed Appl:143–181. https://doi.org/10.1007/978-981-15-0283-5_6/COVER
Janib SM, Moses AS, MacKay JA (2010) Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev 62:1052–1063. https://doi.org/10.1016/j.addr.2010.08.004
Article CAS PubMed PubMed Central Google Scholar
Jędrzak A, Grześkowiak BF, Coy E, Wojnarowicz J, Szutkowski K, Jurga S, Jesionowski T, Mrówczyński R (2019) Dendrimer based theranostic nanostructures for combined chemo- and photothermal therapy of liver cancer cells in vitro. Colloids Surfaces B Biointerfaces 173:698–708. https://doi.org/10.1016/j.colsurfb.2018.10.045
Article CAS PubMed Google Scholar
Jiang Y, Lv L, Shi H, Hua Y, Lv W, Wang X, Xin H, Xu Q (2016) PEGylated Polyamidoamine dendrimer conjugated with tumor homing peptide as a potential targeted delivery system for glioma. Colloids Surfaces B Biointerfaces 147:242–249. https://doi.org/10.1016/j.colsurfb.2016.08.002
Article CAS PubMed Google Scholar
Juneja M, Suthar T, Pardhi VP, Ahmad J, Jain K (2022) Emerging trends and promises of nanoemulsions in therapeutics of infectious diseases. 17:793–812. https://doi.org/10.2217/nnm-2022-0006
Li D, Fan Y, Shen M, Bányai I, Shi X (2019) Design of dual drug-loaded dendrimer/carbon dot nanohybrids for fluorescence imaging and enhanced chemotherapy of cancer cells. J Mater Chem B 7:277–285. https://doi.org/10.1039/C8TB02723D
Article CAS PubMed Google Scholar
Li H, Sun J, Zhu H, Wu H, Zhang H, Gu Z, Luo K (2021) Recent advances in development of dendriticpolymer-based nanomedicines for cancer diagnosis. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13. https://doi.org/10.1002/wnan.1670
Liu H, Wang H, Xu Y, Guo R, Wen S, Huang Y, Liu W, Shen M, Zhao J, Zhang G, Shi X (2014) Lactobionic acid-modified dendrimer-entrapped gold nanoparticles for targeted computed tomography imaging of human hepatocellular carcinoma. ACS Appl Mater Interfaces:6944–6953. https://doi.org/10.1021/am500761x
Liu J, Xiong Z, Zhang J, Peng C, Klajnert-Maculewicz B, Shen M, Shi X (2019) Zwitterionic gadolinium(III)-complexed dendrimer-entrapped gold nanoparticles for enhanced computed tomography/magnetic resonance imaging of lung cancer metastasis. ACS Appl Mater Interfaces 11:15212–15221. https://doi.org/10.1021/acsami.8b21679
Article CAS PubMed Google Scholar
Longmire M, Choyke P, Kobayashi H (2008) Dendrimer-based contrast agents for molecular imaging. Curr Top Med Chem 8:1180–1186. https://doi.org/10.2174/156802608785849021
Article CAS PubMed PubMed Central Google Scholar
Luong D, Sau S, Kesharwani P, Iyer AK (2017) Polyvalent folate-dendrimer-coated iron oxide theranostic nanoparticles for simultaneous magnetic resonance imaging and precise cancer cell targeting. Biomacromolecules 18:1197–1209. https://doi.org/10.1021/acs.biomac.6b01885
Article CAS PubMed PubMed Central Google Scholar
McCarthy JR, Weissleder R (2008) Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev 60:1241–1251. https://doi.org/10.1016/j.addr.2008.03.014
Article CAS PubMed PubMed Central Google Scholar
Mendoza-Nava H, Ferro-Flores G, Ramírez FDM, Ocampo-García B, Santos-Cuevas C, Aranda-Lara L, Azorín-Vega E, Morales-Avila E, Isaac-Olivé K (2016) 177Lu-dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity: a potential theranostic radiopharmaceutical. J Nanomater 2016. https://doi.org/10.1155/2016/1039258
Mignani S, Shi X, Ceña V, Rodrigues J, Tomas H, Majoral JP (2021) Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio)pharmaceuticals in cancer therapy. J Control Release 332:346–366. https://doi.org/10.1016/j.jconrel.2021.03.003
Article CAS PubMed Google Scholar
Nolte T, Gross-Weege N, Schulz V (2020) (Hybrid) SPECT and PET Technologies, in: Recent Results Cancer Res: pp. 111–133. https://doi.org/10.1007/978-3-030-42618-7_3
Ouyang Z, Gao Y, Shen M, Shi X (2021) Dendrimer-based nanohybrids in cancer photomedicine. Mater Today Bio 10. https://doi.org/10.1016/j.mtbio.2021.100111
Qiao Z, Shi X (2015) Dendrimer-based molecular imaging contrast agents. Prog Polym Sci 44:1–27. https://doi.org/10.1016/j.progpolymsci.2014.08.002
Article CAS Google Scholar
Ray S, Li Z, Hsu C, Hwang L, Lin Y, Chou P (2018) Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics. Theranostics 8. https://doi.org/10.7150/thno.27828
Salimi M, Sarkar S, Saber R, Delavari H, Alizadeh AM, Mulder HT (2018) Magnetic hyperthermia of breast cancer cells and MRI relaxometry with dendrimer-coated iron-oxide nanoparticles. Cancer Nanotechnol 9. https://doi.org/10.1186/s12645-018-0042-8
Saluja V, Mishra Y, Mishra V, Giri N, Nayak P (2021) Dendrimers based cancer nanotheranostics: an overview. Int J Pharm 600. https://doi.org/10.1016/j.ijpharm.2021.120485
Sekar TV, Paulmurugan R (2016) Theranostic imaging of cancer gene therapy, in: Methods Mol. Biol., pp. 241–254. https://doi.org/10.1007/978-1-4939-3813-1_20
Shen JM, Li XX, Fan LL, Zhou X, Han JM, Jia MK, Wu LF, Zhang XX, Chen J (2017) Heterogeneous dimer peptide-conjugated polylysine dendrimer-Fe3O4 composite as a novel nanoscale molecular probe for early diagnosis and therapy in hepatocellular carcinoma. Int J Nanomedicine 12:1183–1200. https://doi.org/10.2147/IJN.S126887
Article CAS PubMed PubMed Central Google Scholar
Shi X, Wang S, Meshinchi S, Van Antwerp ME, Bi X, Lee I, Baker JR (2007) Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and imaging. Small 3:1245–1252. https://doi.org/10.1002/smll.200700054
Article CAS PubMed Google Scholar
Shu G, Chen M, Song J, Xu X, Lu C, Du Y, Xu M, Zhao Z, Zhu M, Fan K, Fan X, Fang S, Tang B, Dai Y, Du Y, Ji J (2021) Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+ as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer. Bioact Mater 6:1423–1435. https://doi.org/10.1016/j.bioactmat.2020.10.020
Article CAS PubMed Google Scholar
Song C, Shen M, Rodrigues J, Mignani S, Majoral JP, Shi X (2020) Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review. Coord Chem Rev 421. https://doi.org/10.1016/j.ccr.2020.213463
Strable E, Bulte JWM, Moskowitz B, Vivekanandan K, Allen M, Douglas T (2001) Synthesis and characterization of soluble iron oxide-dendrimer composites. Chem Mater 13:2201–2209. https://doi.org/10.1021/cm010125i
Article CAS Google Scholar
Taratula O, Schumann C, Duong T, Taylor KL, Taratula O (2015) Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy. Nanoscale 7:3888–3902. https://doi.org/10.1039/c4nr06050d
Article CAS PubMed Google Scholar
Taratula O, Schumann C, Naleway MA, Pang AJ, Chon KJ, Taratula O (2013) A multifunctional theranostic platform based on phthalocyanine-loaded dendrimer for image-guided drug delivery and photodynamic therapy. Mol Pharm 10:3946–3958. https://doi.org/10.1021/mp400397t
Article CAS PubMed Google Scholar
Wei P, Chen J, Hu Y, Li X, Wang H, Shen M, Shi X (2016) Dendrimer-stabilized gold nanostars as a multifunctional theranostic nanoplatform for CT imaging, photothermal therapy, and gene silencing of Tumors. Adv Healthc Mater 5:3203–3213. https://doi.org/10.1002/adhm.201600923
Article CAS PubMed Google Scholar
Xiao T, Li D, Shi X, Shen M (2020) PAMAM dendrimer-based nanodevices for nuclear medicine applications. Macromol Biosci 20. https://doi.org/10.1002/mabi.201900282
Xie L, Ji X, Zhang Q, Wei Y (2022) Curcumin combined with photodynamic therapy, promising therapies for the treatment of cancer. Biomed Pharmacother 146. https://doi.org/10.1016/j.biopha.2021.112567
Xing Y, Zhu J, Zhao L, Xiong Z, Li Y, Wu S, Chand G, Shi X, Zhao J (2018) SPECT/CT imaging of chemotherapy-induced tumor apoptosis using 99mTc-labeled dendrimer-entrapped gold nanoparticles. Drug Deliv 25:1384–1393. https://doi.org/10.1080/10717544.2018.1474968
Article CAS PubMed PubMed Central Google Scholar
Xiong H, Liu S, Wei T, Cheng Q, Siegwart DJ (2020) Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. J Control Release 325:198–205. https://doi.org/10.1016/j.jconrel.2020.06.030
Article CAS PubMed PubMed Central Google Scholar
Xu X, Liu K, Wang Y, Zhang C, Shi M, Wang P, Shen L, Xia J, Ye L, Shi X, Shen M (2019) A multifunctional low-generation dendrimer-based nanoprobe for the targeted dual mode MR/CT imaging of orthotopic brain gliomas. J Mater Chem B 7:3639–3643. https://doi.org/10.1039/c9tb00416e
Article CAS Google Scholar
Xue Y, Gao Y, Meng F, Luo L (2021) Recent progress of nanotechnology-based theranostic systems in cancer treatments. Cancer Biol Med 18:336–351. https://doi.org/10.20892/j.issn.2095-3941.2020.0510
Article CAS PubMed PubMed Central Google Scholar
Yan G, Zhuo R (2001) Research progress of magnetic resonance imaging contrast agents. Chin Sci Bull 46:1233–1237. https://doi.org/10.1007/BF03184316
Article CAS Google Scholar
Ye L, Chen Y, Mao J, Lei X, Yang Q, Cui C (2021) Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors. J Exp Clin Cancer Res 40. https://doi.org/10.1186/s13046-021-02105-3
Yeh BM, FitzGerald PF, Edic PM, Lambert JW, Colborn RE, Marino ME, Evans PM, Roberts JC, Wang ZJ, Wong MJ, Bonitatibus PJ (2017) Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies. Adv Drug Deliv Rev 113:201–222. https://doi.org/10.1016/j.addr.2016.09.001
Article CAS PubMed Google Scholar
Zhao L, Zhu J, Cheng Y, Xiong Z, Tang Y, Guo L, Shi X, Zhao J (2015) Chlorotoxin-conjugated multifunctional dendrimers labeled with radionuclide 131I for single photon emission computed tomography imaging and radiotherapy of gliomas. ACS Appl Mater Interfaces 7:19798–19808. https://doi.org/10.1021/acsami.5b05836
Article CAS PubMed Google Scholar
Zheng F, Xiong W, Sun S, Zhang P, Zhu JJ (2019) Recent advances in drug release monitoring. Nano 8:391–413. https://doi.org/10.1515/nanoph-2018-0219
Article CAS Google Scholar
Zheng L, Zhu J, Shen M, Chen X, Baker JR, Wang SH, Zhang G, Shi X (2013) Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles. MedChemComm 4:1001–1005. https://doi.org/10.1039/c3md00050h
Article CAS Google Scholar
Zhu J, Fu F, Xiong Z, Shen M, Shi X (2015b) Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells. Colloids Surfaces B Biointerfaces 133:36–42. https://doi.org/10.1016/j.colsurfb.2015.05.040
Article CAS PubMed Google Scholar
Zhu J, Wang G, Alves CS, Tomás H, Xiong Z, Shen M, Rodrigues J, Shi X (2018) Multifunctional dendrimer-entrapped gold nanoparticles conjugated with doxorubicin for pH-responsive drug delivery and targeted computed tomography imaging. Langmuir 34:12428–12435. https://doi.org/10.1021/acs.langmuir.8b02901
Article CAS PubMed Google Scholar
Zhu J, Xiong Z, Shen M, Shi X (2015a) Encapsulation of doxorubicin within multifunctional gadolinium-loaded dendrimer nanocomplexes for targeted theranostics of cancer cells. RSC Adv 5:30286–30296. https://doi.org/10.1039/c5ra01215e
Article Google Scholar
Zhu J, Zheng L, Wen S, Tang Y, Shen M, Zhang G, Shi X (2014) Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials 35:7635–7646. https://doi.org/10.1016/j.biomaterials.2014.05.046
Article CAS PubMed Google Scholar

Download references

Acknowledgments

The authors acknowledge Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, government of India, for providing facilities to write this manuscript. Authors, Dr. Keerti Jain and Ms. Anchal Pathak, acknowledge Indian Council of Medical Research (ICMR), New Delhi, for the financial support in the form of ICMR Extramural Research Project (Project ID: 2020-4686; Ref. No. 5/13/34/2020/NCD-III). The NIPER-Raebareli communication number for this manuscript is NIPER-R/Communication/388.

Conflict of Interest

The authors declare no conflict of interest related to this manuscript.

Author information

Authors and Affiliations

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Lucknow, India
Anchal Pathak & Keerti Jain
Department of Pharmacology and Toxicology/Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Lucknow, India
Saba Naqvi

Authors

Anchal Pathak
View author publications
You can also search for this author in PubMed Google Scholar
Saba Naqvi
View author publications
You can also search for this author in PubMed Google Scholar
Keerti Jain
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Keerti Jain .

Editor information

Editors and Affiliations

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Lucknow, India
Keerti Jain
Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India
N. K. Jain

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Pathak, A., Naqvi, S., Jain, K. (2023). Functionalized Dendrimers: Promising Nanocarriers for Theranostic Applications. In: Jain, K., Jain, N.K. (eds) Multifunctional And Targeted Theranostic Nanomedicines. Springer, Singapore. https://doi.org/10.1007/978-981-99-0538-6_8

Download citation

DOI: https://doi.org/10.1007/978-981-99-0538-6_8
Published: 24 August 2023
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-0537-9
Online ISBN: 978-981-99-0538-6
eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics