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Theranostic Applications of Functionalized Polymeric Micelles

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Multifunctional And Targeted Theranostic Nanomedicines

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Abstract

Curiosity in theranostic agents has continuously been growing because of its unique ability of simultaneous detection and therapy. Polymeric micelles are used as diagnostic imaging, drug, biologics, and gene delivery carriers. These nanosized agents can be made from a variety of polymers. Polymeric micelles have some advantages over others, including the ability to load poorly soluble drugs, biocompatibility, longevity, the ability to accumulate in pathological areas with compromised vasculature, high stability, incorporation of imaging contrast agents, ability to change the release of the combined pharmaceutical ingredient, targeted delivery, and so on. In stimuli-responsive therapy, pH-thermo, ultrasound, enzyme, and light-sensitive block copolymers are used. Moreover, surface modification ability makes them suitable for targeting various diseases or targeting intracellular spaces. Additionally, the integration of imaging moiety makes them suitable for their use in in vivo biodistribution studies. Therefore, such “smart,” multifunctional polymeric micelles act as a key to improvising the efficacy of current treatments. Overall, polymeric micelle theranostic nanosystems are a more personalized and effective form of treatment. In the current chapter, we discussed the theranostic use of polymeric micelles in various diseases and theranostic applications of functionalized polymeric micelles.

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Acknowledgements

MSD and BA acknowledge the award of Research Fellowships by the Department of Pharmaceuticals, Ministry of Chemical and Fertilizer, Government of India. The authors acknowledge support from the Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Govt. of India. NIPER-Raebareli communication number for this manuscript is NIPER-R/Communication/328.

Conflicts of Interest

The authors declare no conflict of interest.

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  1. Bhakti S. Aiwale and Monika S. Deore contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Regulatory Toxicology/Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Lucknow, UP, India

    Bhakti S. Aiwale & Saba Naqvi

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Lucknow, India

    Monika S. Deore & Keerti Jain

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  1. Bhakti S. Aiwale
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  2. Monika S. Deore
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  3. Keerti Jain
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  4. Saba Naqvi
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Correspondence to Saba Naqvi .

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Editors and Affiliations

  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Lucknow, India

    Keerti Jain

  2. Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India

    N. K. Jain

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Aiwale, B.S., Deore, M.S., Jain, K., Naqvi, S. (2023). Theranostic Applications of Functionalized Polymeric Micelles. In: Jain, K., Jain, N.K. (eds) Multifunctional And Targeted Theranostic Nanomedicines. Springer, Singapore. https://doi.org/10.1007/978-981-99-0538-6_13

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  • DOI: https://doi.org/10.1007/978-981-99-0538-6_13

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