Abstract
Polymeric micelles (PM) developed in solution by self-assembling of amphiphilic polymers and represents an advanced tool to overcome several issues related to drug delivery like low aqueous solubility drug that may lead to low drug permeability across biological barriers. PM have several benefits, such as their tiny size, high solubility, ease of sterilizing, and controlled release of pharmaceuticals. Since the integrated medicine may be released rapidly in vivo, the physical stability of this carrier is a crucial concern. To effectively develop micelles that can carry drugs to their sites of action, the significant effort still must be done in understanding how PM interact with plasmatic and cellular components. This chapter describes the advantages and challenges of PM for the delivery of proteins, oral uptake of PM, types of polymers utilized in the administration of micellar drugs, and PM for multiple functionality and protein delivery.
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Ashique, S., Garg, A., Hussain, A., Bhatt, S., Agrawal, A., Mishra, N. (2023). Polymeric Micelles in the Delivery of Proteins. In: Singh, S.K., Gulati, M., Mutalik, S., Dhanasekaran, M., Dua, K. (eds) Polymeric Micelles: Principles, Perspectives and Practices. Springer, Singapore. https://doi.org/10.1007/978-981-99-0361-0_12
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