Skip to main content

Abstract

Herpes simplex virus (HSV) invades the central nervous system (CNS) and causes a series of inflammatory changes. When it mainly involves the brain parenchyma, it is called herpes simplex virus encephalitis (HSVE), which is the most common CNS viral infectious disease. The incidence of herpes simplex virus encephalitis abroad is 0.4–1/100000, accounting for 20–68% of all viral encephalitis. The virus most often attacks the temporal and frontal lobes and the limbic system and is also known as acute necrotizing encephalitis or hemorrhagic encephalitis because it often causes hemorrhagic necrosis and/or metabolic damage to the brain parenchyma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Sili U, Kaya A, Mert A, et al. Herpes simplex virus encephalitis: clinical manifestations, diagnosis and outcome in 106 adult patients. J Clin Virol. 2014;60(2):112–8.

    Article  PubMed  Google Scholar 

  2. Wu H. Early diagnostic and prognostic value of electroencephalography in herpes simplex virus encephalitis. Chin J Pract Neurol Disord. 2015;18(2):141–2.

    Google Scholar 

  3. Wang X, Zou Q, Pu T. Herpes simplex virus encephalitis 60 clinical analysis of cases. Sichuan Med. 2012;33(8):1433–5.

    Google Scholar 

  4. Zhang Y, Li Y, Wang X, et al. Herpes simplex virus encephalitis CT and MRI manifestations. Radiol Pract. 2014;29(3):276–8.

    Google Scholar 

  5. Kataoka H, Ueno S. Herpes simplex virus and acute fulminant disseminated encephalitis with extensive white matter lesions. J Infect. 2009;59(1):70–2.

    Article  PubMed  Google Scholar 

  6. Leib DA. Herpes simplex virus encephalitis: toll-free access to the brain. Cell Host Microbe. 2012;12(6):731–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Linde A, Klapper PE, Monteyne P, et al. Specific diagnostic methods for herpesvirus infections of the central nervous system: a consensus review by the European Union concerted action on virus meningitis and encephalitis. Clin Diagn Virol. 1997;8(2):83–104.

    Article  CAS  PubMed  Google Scholar 

  8. Ge M, Jin Z. Anti-varicella—advances in research on herpes zoster virus drugs. Foreign Med Dermatol Venereol Div. 1996;06:344–8.

    Google Scholar 

  9. Shen Y, Chen J. Anti-varicella- advances in research on herpes zoster virus drugs. Anhui Med. 2012;16(1):4–6.

    CAS  Google Scholar 

  10. Kennedy PG, Barrass JD, Graham DI, et al. Studies on the pathogenesis of neurological diseases associated with varicella-zoster virus. Neuropathol Appl Neurobiol. 1990;16(4):305–16.

    Article  CAS  PubMed  Google Scholar 

  11. Yu H, Zhu Q. Varicella—current status of research on herpes zoster virus infection. China’s Plan Immun. 2001;7(2):59–62.

    Google Scholar 

  12. Qi J, Li Y. Varicella—recent research in the treatment of herpes zoster virus infection. Int J Dermatol Venereol. 1996;22(2):83–6.

    Google Scholar 

  13. Grahn A, Studahl M. Varicella-zoster virus infections of the central nervous system. Prognosis, diagnostics and treatment. J Infect. 2015;71(3):281–93.

    Article  PubMed  Google Scholar 

  14. Hu DJ, Yan JC, Zhang WD. Viral encephalitis CT diagnosis. Radiol Pract. 2001;16(6):405–7.

    Google Scholar 

  15. Li S. Children EB viral encephalitis 24 clinical analysis of cases. Chin J Pract Pediat. 2004;19(3):172–3.

    Google Scholar 

  16. Zhang M, Yang M. Children EB advances in viral encephalitis research. Med Rev. 2010;16(16):2444–6.

    Google Scholar 

  17. Spagnolo F, Ceppi D, Cardamone R, et al. Frontotemporal dementia with parkinsonism presenting as posterior cortical atrophy. Mov Disord. 2011;26(11):2131–2.

    Article  PubMed  Google Scholar 

  18. Hagemann G, Mentzel HJ, Weisser H, et al. Multiple reversible MR signal changes caused by Epstein-Barr virus encephalitis. Am J Neuroradiol. 2006;27(7):1447–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Wang C, Zhan X. Progress in the study of human herpesvirus 6 infection. J Pediatr Pharm. 2014;20(8):62–5.

    CAS  Google Scholar 

  20. Zhao M, Jiang SC. Status of research on human herpes virus 6 type. Infect Dis Info. 1999;12(4):165–6.

    Google Scholar 

  21. Hill JA, Venna N. Human herpesvirus 6 and the nervous system. Handb Clin Neurol. 2014;123:327–535.

    Article  PubMed  Google Scholar 

  22. Harberts E, Yao K, Wohler JE, et al. Human herpesvirus-6 entry into the central nervous system through the olfactory pathway. Proc Natl Acad Sci U S A. 2011;108(33):13734–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Caserta MT, Hall CB, Schnabel K, et al. Diagnostic assays for active infection with human herpesvirus 6(HHV-6). J Clin Virol. 2010;48(1):55–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Ryo B, In Yeol T. Ape herpes B viral infection. Jpn Med Present. 2006;27(9):398.

    Google Scholar 

  25. Li J, Xiang Z. Brief analysis of the lethality of monkey B virus in humans. Chin J Comp Med. 2017;27(9):98–103.

    Google Scholar 

  26. Li X, He J. Monkey B advances in virus detection technology research and application. Lab Anim Sci. 2007;24(4):59–62.

    Google Scholar 

  27. Davenport DS, Johnson DR, Holmes GP, et al. Diagnosis and management of human B virus (herpesvirus simiae) infections in Michigan. Clin Infect Dis. 1994;19(1):33–41.

    Article  CAS  PubMed  Google Scholar 

  28. Amalfitano A, Martin LG, Fluck MM. Different roles for two enhancer domains in the organ and age specific pattern of polyomavirus replication in the mouse. Mol Cell Biol. 1992;12(8):3628–35.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. de La Roche Saint André C, Mazur S, Feunteun J. Viral genomes maintained extrachromosomally in hamster polyoma virus induced lymphomas display a cell specific replication in vitro. J Virol. 1993;67(12):7172–80.

    Article  PubMed  Google Scholar 

  30. Andrews DW, Gupta J, Abisdris G. Evidence that the middle T antigen of polyomavirus interacts with the membrane skeleton. Mol Cell Biol. 1993;13(8):4703–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Baker TS, Newcomb WW, Olson NH, et al. Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction. Biophys J. 1991;60(6):1445–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Yang Y, Du Y. Advances in tick-borne encephalitis research. Chin J Epidemiol. 2016;37(10):1435–8.

    CAS  Google Scholar 

  33. Hegde V, Aziz Z, Kumar S, et al. Dengue encephalitis with predominant cerebellar involvement: report of eight cases with MR and CT imaging features. Eur Radiol. 2015;25(3):719–25.

    Article  PubMed  Google Scholar 

  34. Zawadzki R, Garkowski A, Kubas B, et al. Evaluation of imaging methods in tick-borne encephalitis. Pol J Radiol. 2017;82:742–7.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Pichler A, Sellner J, Harutyunyan G, et al. Magnetic resonance imaging and clinical findings in adults with tick- borne encephalitis. J Neurol Sci. 2017;375:266–9.

    Article  PubMed  Google Scholar 

  36. Arahata Y, Fujii K, Nishimura T, et al. Longitudinal magnetic resonance imaging changes in Japanese encephalitis. Brain Dev. 2019;41(8):731–4.

    Article  PubMed  Google Scholar 

  37. Chu SX. West Nile virus encephalitis. World core medical journal abstracts. Neurol Fascicle. 2006;2(6):1–2.

    Google Scholar 

  38. Jin S, Zhang H. Advances in the study of West Nile virus. Chin J Pathog Biol. 2009;4(8):623–5.

    Google Scholar 

  39. Turell MJ, Dohm DJ, Sardelis MR, et al. An update on the potential of north American mosquitoes (diptera: culicidae) to transmit West Nile virus. J Med Entomol. 2005;42(1):57–62.

    Article  PubMed  Google Scholar 

  40. Hayes EB, Sejvar JJ, Zaki SR, et al. Virology, pathology, and clinical manifestations of west nile virus disease. Emerg Infect Dis. 2005;11(8):1174–9.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Ali M, Safriel Y, Sohi J, et al. West nile virus infection: MR imaging findings in the nervous system. Am J Neuroradiol. 2005;26(2):289.

    PubMed  PubMed Central  Google Scholar 

  42. Evans IA, Hueston L, Doggett SL. Murray Valley encephalitis virus. N S W Public Health Bull. 2009;20(11/12):195.

    Article  PubMed  Google Scholar 

  43. Lee E, Lobigs M. Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus. J Virol. 2002;76(10):4901–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Einsiedel L, Kat E, Ravindran J, et al. MR findings in Murray Valley encephalitis. Am J Neuroradiol. 2003;24(7):1379–82.

    PubMed  PubMed Central  Google Scholar 

  45. Lamp B, Dietzel E, Kolesnikova L, et al. Nipah virus entry and egress from polarized epithelial cells. J Virol. 2013;87(6):3143–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Ang BSP, Lim TCC, Wang L. Nipah virus infection. J Clin Microbiol. 2018;56(6):e01875–17.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Li H. Practical infectious disease imaging. Beijing: People’s Health Press; 2014.

    Google Scholar 

  48. Diaz LA, Coffey LL, Burkett-Cadena ND, et al. Reemergence of St. Louis encephalitis virus in the Americas. Emerg Infect Dis. 2018;24(12):2150–7.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Wasay M, Diazarrastia R, Suss RA, et al. St Louis encephalitis: a review of 11 cases in a 1995 Dallas, Tex, epidemic. Arch Neurol. 2000;57(1):114.

    Article  CAS  PubMed  Google Scholar 

  50. Dourmashkin RR, Dunn G, Castano V, et al. Evidence for an enterovirus as the cause of encephalitis lethargica. BMC Infect Dis. 2012;12(1):136.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Wang SM, Lei HY, Huang KJ, et al. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis. 2003;188(4):564–70.

    Article  CAS  PubMed  Google Scholar 

  52. Lei Z, Jie Y, Ojcius DM, et al. Novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern China. PLoS One. 2013;8(12):e85023.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Science Press

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Xia, S., Wang, S., Liu, Q., Fu, Z., Jin, Y., Li, Q. (2023). Intracranial Viral Infection. In: Li, H., Wang, J., Zhang, X. (eds) Radiology of Infectious and Inflammatory Diseases - Volume 1. Springer, Singapore. https://doi.org/10.1007/978-981-99-0039-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-0039-8_12

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-0038-1

  • Online ISBN: 978-981-99-0039-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics