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The Influence of Maxwell Stress on the Cell Electrodeformation and Electroporation

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The Proceedings of the 18th Annual Conference of China Electrotechnical Society (ACCES 2023)

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 1179))

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Abstract

The exposure of cells to a pulsed electric field can lead to electroporation (EP) and electrodeformation (ED). However, the ED effect rarely considered in the existing EP models. Based on the finite element simulation soft COMSOL, we investigate the distribution of Maxwell stress and its effect on cell deformation in two situations with considered pore formation or not. Our simulation reveal that the simulation result of the model considered pore formation and ED is more consistent with the experiment result. We analysis in detail the relation between the cell deformation and Maxwell stress and electric field distribution using the EP and ED coupling model in the situation when the interior conductivity is larger than the exterior one. At the beginning of the pulse, the distribution of the cell deformation and Maxwell stress is agreement. During the pulse, the Maxwell stress in z direction is one order of magnitude greater than that in r direction. The deformation is major affected by the Maxwell stress in z direction, leading to the cell deform to prolate shape, which is in good agreement with the experiment. When the pulse removed about 10 µs later, our simulation observed a rebound peak in cell deformation curve. The conclusion of this paper is of great significance for improving the efficiency of cell EP, studying the recovery of cell after EP and promoting the application of EP technology in biomedical field.

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Acknowledgments

This work is supported by China Postdoctoral Science Foundation (No. 2020M671917) and National Natural Science Foundation of China (No. 62201544).

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Authors and Affiliations

  1. Quan Zhou Institute of Equipment Manufacturing, Haixi Institutes, Chinese Academy of Sciences, Jinjiang, 362200, China

    Linying Liu, Fanyu Guo & Shengnan Zou

Authors
  1. Linying Liu
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  2. Fanyu Guo
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  3. Shengnan Zou
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Correspondence to Shengnan Zou .

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Editors and Affiliations

  1. Tianjin University of Technology, Tianjin, Tianjin, China

    Qingxin Yang

  2. East China Jiaotong University, Nanchang, Jiangxi, China

    Zewen Li

  3. Hunan University, Changsha, Hunan, China

    An Luo

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Liu, L., Guo, F., Zou, S. (2024). The Influence of Maxwell Stress on the Cell Electrodeformation and Electroporation. In: Yang, Q., Li, Z., Luo, A. (eds) The Proceedings of the 18th Annual Conference of China Electrotechnical Society. ACCES 2023. Lecture Notes in Electrical Engineering, vol 1179. Springer, Singapore. https://doi.org/10.1007/978-981-97-1428-5_59

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  • DOI: https://doi.org/10.1007/978-981-97-1428-5_59

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-97-1427-8

  • Online ISBN: 978-981-97-1428-5

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